NDLI: Hypoxia regulates CD9-mediated keratinocyte migration via the P38/MAPK pathway

Content Provider	PubMed Central
Author	Jiang, Xupin Guo, Xiaowei Xu, Xue Teng, Miao Huang, Chong Zhang, Dongxia Zhang, Qiong Zhang, Jiaping Huang, Yuesheng
Copyright Year	2014
Abstract	Keratinocyte migration is an early event in the wound healing process. Although we previously found that CD9 downregulation is required for the keratinocyte migration during wound repair, the mechanism of how CD9 expression is regulated remains unclear. Here, we observed the effect of hypoxia (2% O2) on CD9 expression and keratinocyte migration. CD9 expression was downregulated and keratinocyte migration was increased under hypoxic conditions. In addition, CD9 overexpression reversed hypoxia-induced cell migration. We also found that hypoxia activated the p38/MAPK pathway. SB203580, a p38/MAPK inhibitor, increased CD9 expression and inhibited keratinocyte migration under hypoxia, while MKK6 (Glu) overexpression decreased CD9 expression and promoted hypoxic keratinocyte migration. Our results demonstrate that hypoxia regulates CD9 expression and CD9-mediated keratinocyte migration via the p38/MAPK pathway.
Related Links	http://dx.doi.org/10.1038/srep06304
Starting Page	6304
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	4
Language	English
Publisher	Nature Publishing Group
Publisher Date	2014-09-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Hypoxia regulates CD9-mediated keratinocyte migration via the P38/MAPK pathway