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Content Provider | PubMed Central |
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Author | Kozlova, Elena Chernysh, Alexander Moroz, Victor Gudkova, Olga Victoria, Sergunova Kuzovlev, Artem |
Copyright Year | 2014 |
Abstract | Hemin is the product of hemoglobin oxidation. Some diseases may lead to a formation of hemin. The accumulation of hemin causes destruction of red blood cells (RBC) membranes. In this study the process of development of topological defects of RBC membranes within the size range from nanoscale to microscale levels is shown. The formation of the grain-like structures in the membrane (“grains”) with typical sizes of 120–200 nm was experimentally shown. The process of formation of “grains” was dependent on the hemin concentration and incubation time. The possible mechanism of membrane nanostructure alterations is proposed. The kinetic equations of formation and transformation of small and medium topological defects were analyzed. This research can be used to study the cell intoxication and analyze the action of various agents on RBC membranes. |
Related Links | http://dx.doi.org/10.1038/srep06033 |
Starting Page | 6033 |
File Format | |
ISSN | 20452322 |
e-ISSN | 20452322 |
Journal | Scientific Reports |
Volume Number | 4 |
Language | English |
Publisher | Nature Publishing Group |
Publisher Date | 2014-08-12 |
Access Restriction | Open |
Rights Holder | Nature Publishing Group |
Subject Keyword | Science and technology Research in Higher Education |
Content Type | Text |
Resource Type | Article |
Subject | Multidisciplinary |
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