NDLI: Diffusion Tensor Imaging Reveals Acute Subcortical Changes after MildBlast-Induced Traumatic Brain Injury

Content Provider	PubMed Central
Author	Alaa, Kamnaksh Budde, Matthew D. Kovesdi, Erzsebet Long, Joseph B. Frank, Joseph A. Agoston, Denes V.
Copyright Year	2014
Abstract	Mild blast-induced traumatic brain injury (mbTBI) poses special diagnostic challenges dueto its overlapping symptomatology with other neuropsychiatric conditions and the lack ofobjective outcome measures. Diffusion tensor imaging (DTI) can potentially provideclinically relevant information toward a differential diagnosis. In this study, we aimed todetermine if single and repeated (5 total; administered on consecutive days) mild blastoverpressure exposure results in detectable structural changes in the brain, especially inthe hippocampus. Fixed rat brains were analyzed by ex vivo DTI at 2 h and 42 days afterblast (or sham) exposure(s). An anatomy-based region of interest analysis revealedsignificant interactions in axial and radial diffusivity in a number of subcorticalstructures at 2 h only. Differences between single- and multiple-injured rats were largelyin the thalamus but not the hippocampus. Our findings demonstrate the value and thelimitations of DTI in providing a better understanding of mbTBI pathobiology.
Related Links	http://dx.doi.org/10.1038/srep04809
Starting Page	4809
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	4
Language	English
Publisher	Nature Publishing Group
Publisher Date	2014-05-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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