NDLI: A point process model-based framework reveals reinforcement mechanisms in striatum during high frequency STN DBS

Content Provider	IEEE Xplore Digital Library
Author	Santaniello, S. Gale, J.T. Montgomery, E.B. Sarma, S.V.
Copyright Year	2012
Description	Author affiliation: Department of Neurosciences, Cleveland Clinic, OH 44195 USA (Gale, J.T.) \|\| Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218 USA (Santaniello, S.; Sarma, S.V.) \|\| Department of Neurology, University of Alabama at Birmingham, 35294 USA (Montgomery, E.B.)
Abstract	Striatum is a major stage of the motor loop but, despite a pivotal role in the execution of movements, it has been poorly studied thus far under Parkinsonian conditions and Deep Brain Stimulation (DBS). We propose a computational framework to analyze the spiking activity of striatal neurons under several conditions. This framework combines point process models and single unit recordings, and separately evaluates the effects of the spiking history, DBS frequency, and other cells on the neuronal discharge pattern, thus giving a full characterization of non-stationary neuronal dynamics and inter-neuronal dependencies. We applied this framework to 166 striatal neurons collected in a monkey both at rest and during DBS (30–130 Hz). Our analysis was conducted both before and after treatment of the animal with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which evoked Parkinsonian-like motor disorders. We reported that high frequency (≥100 Hz) DBS reduces non-stationary dynamics and inter-neuronal dependencies by regularizing the discharge patterns both in MPTP and normal striatum, while the combination of MPTP and low frequency (30–80 Hz) DBS enhances these features, thus suggesting that pattern regularization in striatum might contribute to the therapeutic effect of high frequency DBS and presumably results from the overlap of feed-forward and feedback activation along the motor loop (reinforcement).
Starting Page	1645
Ending Page	1650
File Size	279074
Page Count	6
File Format	PDF
ISBN	9781467320658
ISSN	07431546
e-ISBN	9781467320665
e-ISBN	9781467320641
DOI	10.1109/CDC.2012.6426098
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-12-10
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Satellite broadcasting Neurons Discharges (electric) Animals History Partial discharges Humans
Content Type	Text
Resource Type	Article
Subject	Control and Optimization Control and Systems Engineering Modeling and Simulation

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Reinforcement mechanisms in putamen during high frequency STN DBS: A point process study

Reinforcement Mechanisms in Putamen during High Frequency STN DBS: A Point Process Study

Modeling the motor striatum under Deep Brain Stimulation in normal and MPTP conditions

Point process modeling reveals anatomical non-uniform distribution across the Subthalamic Nucleus in Parkinson's disease

Analyzing Local Field Potentials in the healthy basal ganglia under Deep Brain Stimulation

Simulation of PID control schemes for closed-loop deep brain stimulation

Performance analysis of single-site and multiple-site deep brain stimulation in basal ganglia for Parkinson's disease

Partial discharges during impulse tests

Feasibility of DBS Signal for Air/Space Surveillance

A point process model-based framework reveals reinforcement mechanisms in striatum during high frequency STN DBS

Similar Documents

Reinforcement mechanisms in putamen during high frequency STN DBS: A point process study

Reinforcement Mechanisms in Putamen during High Frequency STN DBS: A Point Process Study

Modeling the motor striatum under Deep Brain Stimulation in normal and MPTP conditions

Point process modeling reveals anatomical non-uniform distribution across the Subthalamic Nucleus in Parkinson's disease

Analyzing Local Field Potentials in the healthy basal ganglia under Deep Brain Stimulation

Simulation of PID control schemes for closed-loop deep brain stimulation

Performance analysis of single-site and multiple-site deep brain stimulation in basal ganglia for Parkinson's disease

Partial discharges during impulse tests

Feasibility of DBS Signal for Air/Space Surveillance

A point process model-based framework reveals reinforcement mechanisms in striatum during high frequency STN DBS