NDLI: A compartment based model for the formation of 2-LTR circles after raltegravir intensification

Content Provider	IEEE Xplore Digital Library
Author	Cardozo, E. Fabian Vargas, Cesar A. Zurakowski, Ryan
Copyright Year	2012
Description	Author affiliation: Electrical and Computer Engineering, University of Delaware, Newark, 19716, USA (Cardozo, E. Fabian; Vargas, Cesar A.; Zurakowski, Ryan)
Abstract	Highly Active Antiretroviral Therapy (HAART) can suppress measured Human Immunodeficiency Virus (HIV) plasma viral load below the standard limits of detection in most HIV-positive patients. However it has been shown that the virus persists at undetectable levels and rebounds rapidly when the treatment is interrupted. It has been hypothesized that the virus may continue to replicate efficiently in anatomical compartments with low antiviral concentration, so called “cryptic viremia”. Recent results from an experiment measuring the dynamics of 2-LTR HIV DNA episomes following intensification with the integrase inhibitor raltegravir have provided strong support for the “cryptic viremia” hypothesis. In this paper we introduce a multi-compartment model of HIV viral dynamics including 2-LTR episome concentrations. These compartments represent an isolated anatomical location similar in structure to a lymph node, with diffusion from the plasma decreasing with distance from the plasma. We show that when the size of the compartment is sufficiently large to allow efficient replication in the most remote compartment, the dynamics of measured 2-LTR in the plasma compartment is consistent with the observed patterns in the raltegravir intensification experiment, providing support to the “cryptic viremia” hypothesis. The model presented could be adapted for use in estimating cryptic viremia dynamics from 2-LTR measurements.
Starting Page	4924
Ending Page	4929
File Size	524641
Page Count	6
File Format	PDF
ISBN	9781467320658
ISSN	07431546
e-ISBN	9781467320665
e-ISBN	9781467320641
DOI	10.1109/CDC.2012.6426088
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-12-10
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Portable document format IEEE Xplore
Content Type	Text
Resource Type	Article
Subject	Control and Optimization Control and Systems Engineering Modeling and Simulation

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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A compartment based model for the formation of 2-LTR circles after raltegravir intensification