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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Schiff, S.J. |
| Copyright Year | 2011 |
| Description | Author affiliation: Center for Neural Engineering, and Departments of Engineering Science and Mechanics, Neurosurgery, and Physics, of the Pennsylvania State University, University Park, 16802, USA (Schiff, S.J.) |
| Abstract | Since the 1950s, we have developed mature theories of modern control theory and computational neuroscience with almost no interaction between these disciplines. With the advent of computationally efficient nonlinear Kalman filtering techniques, along with improved neuroscience models that provide increasingly accurate reconstruction of dynamics in a variety of important normal and disease states in the brain, the prospects for a synergistic interaction between these fields are now strong. I show recent examples of the use of nonlinear control theory for the assimilation and control of single neuron and network dynamics, as well as the modulation of oscillatory waves in the cortex, and the assimilation of epileptic seizures. A control framework for modulating Parkinsonian dynamics is presented, and a perspective offered. As the computational models of dynamical diseases such as Parkinson's disease improve, embedding those models within rigorous model-based control frameworks is now feasible. |
| Starting Page | 6487 |
| Ending Page | 6491 |
| File Size | 152356 |
| Page Count | 5 |
| File Format | |
| ISBN | 9781612848006 |
| ISSN | 07431546 |
| e-ISBN | 9781612848013 |
| e-ISBN | 9781612847993 |
| DOI | 10.1109/CDC.2011.6160870 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2011-12-12 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Kalman filters Brain models Biological system modeling Neurons Computational modeling Spatiotemporal phenomena |
| Content Type | Text |
| Resource Type | Article |
| Subject | Control and Optimization Control and Systems Engineering Modeling and Simulation |
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