NDLI: Renal cell carcinoma may evade the immune system by converting CD4+Foxp3- T cells into CD4+CD25+Foxp3+ regulatory T cells: Role of tumor COX-2-derived PGE2.

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Renal cell carcinoma may evade the immune system by converting CD4+Foxp3- T cells into CD4+CD25+Foxp3+ regulatory T cells: Role of tumor COX-2-derived PGE2.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Jinfeng Chu, Yiwei Rong, Ruiming Luo, Feifei Feng, Guiwen Liu, Jia Guo, Liang Zhu, Tongyu Wang, Guomin
Description	Author Affiliation: Li J ( Kidney Transplantation Unit, The First Affiliated Hospital of Zhengzhou University, Shanghai, P.R. China.)
Abstract	Increased CD4+CD25+Foxp3+ regulatory T cells (Tregs) predict poor prognosis in renal cell carcinoma (RCC). The aim of this study was to investigate the underlying causes of the aberrant accumulation of Tregs in RCC. pcDNA3.1-hCOX-2 and control pcDNA3.1 were transfected into the RCC cell line OS-RC-2. Under stimulation of anti-CD3/CD28 antibody and APC cells, isolated CD4+Foxp3- T cells were co-cultured with transfected OS-RC-2 culture medium supernatants and different control supernatants, respectively, and 96 h later, the proportion of Tregs in each group was detected using FACS. The suppressive ability of naturally isolated Tregs and transformed Tregs was also analyzed using [3H]-thymidine methods. The results showed that overexpression of COX-2 in OS-RC-2 cells led to higher expression of prostaglandin E2 (PGE2) in the culture medium supernatants. In addition, there was an apparent incremental increase in the percentage of Tregs in the CD4+Foxp3- T cells cultured with the COX-2-overexpressing OS-RC-2 culture medium supernatants. Furthermore, transformed Tregs had the same suppressive ability as naturally isolated Tregs. In summary, transfected RCC cell line culture medium supernatants were capable of converting CD4+Foxp3- T cells to Tregs by producing high levels of PGE2, while COX-2 inhibitors reduced the proportion of transformed Tregs in a dose-dependent manner. Thus, COX-2 inhibitors may induce a local anti-tumor effect and, in turn, may contribute to the eradication of RCC by decreasing transformed Tregs.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	3
Language	English
Publisher	Spandidos Publications
Publisher Date	2010-11-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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