NDLI: Tetrandrine ameliorates sevofluraneinduced cognitive impairment via the suppression of inflammation and apoptosis in aged rats.

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Tetrandrine ameliorates sevofluraneinduced cognitive impairment via the suppression of inflammation and apoptosis in aged rats.

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Tetrandrine ameliorates sevofluraneinduced cognitive impairment via the suppression of inflammation and apoptosis in aged rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yao, Li Pang, Ling Li, Xingwei Yao, Qun Ma, Hongmei
Description	Author Affiliation: Ma H ( Department of Training, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277100, P.R. China.); Yao L ( Department of Genecology, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277100, P.R. China.); Pang L ( Department of Anesthesiology, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277100, P.R. China.); Li X ( Department of Anesthesiology, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277100, P.R. China.); Yao Q ( Department of Anesthesiology, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277100, P.R. China.)
Abstract	Tetrandrine is a bisbenzylisoquinoline alkaloid extracted from Stephania tetrandra, a traditional Chinese herbal medicine, which has been observed to exert antiinflammatory effects. The aim of the current study was to investigate whether tetrandrine was able to ameliorate sevofluraneinduced cognitive impairment in aged rats. Male 20monthold SpragueDawley rats underwent sevofluraneinduction in an environment containing 2% sevoflurane for 5 h. The Morris water maze test was used to measure the effect of tetrandrine on learning and memory in sevofluranetreated aged rats. Western blot analysis of the protein expression levels of cyclooxygenase2 (COX2), inducible nitric oxide synthase (iNOS) and Bcl2 was conducted. ELISAs were used to measure the levels of interleukin (IL)1ß, tumor necrosis factor (TNF ), nuclear factorκB (NFκB) and caspase3. In the present study, tetrandrine improved the learning and memory deficits observed in sevofluranetreated aged rats. Treatment with tetrandrine reduced the expression levels of COX2, IL1ß, TNF , NFκB, iNOS and caspase3, and increased the Bcl2 protein expression in sevofluranetreated aged rats. In conclusion, the current study indicated that tetrandrine ameliorates sevofluraneinduced cognitive impairment via the suppression of inflammation and apoptosis in aged rats. Thus, tetrandrine may be a potential novel candidate to protect against the effects of sevoflurane anesthesia on cognitive function.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	13
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-06-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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