NDLI: Rhizoma Dioscoreae extract protects against alveolar bone loss by regulating the cell cycle: A predictive study based on the proteinprotein interaction network.

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Rhizoma Dioscoreae extract protects against alveolar bone loss by regulating the cell cycle: A predictive study based on the proteinprotein interaction network.

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Rhizoma Dioscoreae extract protects against alveolar bone loss by regulating the cell cycle: A predictive study based on the proteinprotein interaction network.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Song, Chang-Heng Zhang, Fang-Zhen Xiao, Gary Guishan Chen, Yan-Jing Zhang, Zhi-Guo Ju, Da-Hong Xiang, Li-Hua
Description	Author Affiliation: Zhang ZG ( Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China.); Song CH ( Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China.); Zhang FZ ( Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China.); Chen YJ ( Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China.); Xiang LH ( Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China.); Xiao GG ( School of Pharmaceutical Science, Dalian University of Technology, Dalian, Liaoning 116024, P.R. China.); Ju DH ( Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China.)
Abstract	Rhizoma Dioscoreae extract (RDE) exhibits a protective effect on alveolar bone loss in ovariectomized (OVX) rats. The aim of this study was to predict the pathways or targets that are regulated by RDE, by reassessing our previously reported data and conducting a proteinprotein interaction (PPI) network analysis. In total, 383 differentially expressed genes (≥3fold) between alveolar bone samples from the RDE and OVX group rats were identified, and a PPI network was constructed based on these genes. Furthermore, four molecular clusters (AD) in the PPI network with the smallest Pvalues were detected by molecular complex detection (MCODE) algorithm. Using Database for Annotation, Visualization and Integrated Discovery (DAVID) and Ingenuity Pathway Analysis (IPA) tools, two molecular clusters (A and B) were enriched for biological process in Gene Ontology (GO). Only cluster A was associated with biological pathways in the IPA database. GO and pathway analysis results showed that cluster A, associated with cell cycle regulation, was the most important molecular cluster in the PPI network. In addition, cyclindependent kinase 1 (CDK1) may be a key molecule achieving the cellcycleregulatory function of cluster A. From the PPI network analysis, it was predicted that delayed cell cycle progression in excessive alveolar bone remodeling via downregulation of CDK1 may be another mechanism underling the antiosteopenic effect of RDE on alveolar bone.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	13
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-06-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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