NDLI: Thrombosis recanalization by paeoniflorin through the upregulation of urokinasetype plasminogen activator via the MAPK signaling pathway.

Please wait, while we are loading the content...

Year: 2017 Volume: 15

Year: 2016 Volume: 14

Year: 2016 Volume: 13

Year: 2016 Volume: 13 Issue: 6

Novel synergic antidiabetic effects of Astragalus polysaccharides combined with Crataegus flavonoids via improvement of islet function and liver metabolism.

A novel approach to understanding the role of polymorphic forms of the NR3C1 and TGF-ß1 genes in the modulation of the expression of IL-5 and IL-15 mRNA in asthmatic inflammation.

Integrative analysis of gene expression associated with epilepsy in human epilepsy and animal models.

Knockdown of Rhotekin 2 expression suppresses proliferation and invasion and induces apoptosis in hepatocellular carcinoma cells.

Artemisia capillaris formula inhibits hepatic steatosis via an miR122induced decrease in fatty acid synthase expression in vivo and in vitro.

Urinary microRNA-based signature improves accuracy of detection of clinically relevant prostate cancer within the prostate-specific antigen grey zone.

The downregulation of miR125a5p functions as a tumor suppressor by directly targeting MMP11 in osteosarcoma.

Anticancer activity of taraxerol acetate in human glioblastoma cells and a mouse xenograft model via induction of autophagy and apoptotic cell death, cell cycle arrest and inhibition of cell migration.

NQDI-1, an inhibitor of ASK1 attenuates acute perinatal hypoxic-ischemic cerebral injury by modulating cell death.

A serum microRNA signature as a prognostic factor for patients with advanced NSCLC and its association with tissue microRNA expression profiles.

Tetrandrine ameliorates sevofluraneinduced cognitive impairment via the suppression of inflammation and apoptosis in aged rats.

Treatment of experimental autoimmune uveoretinitis with different natural compounds.

LIF and LIFR expression in the endometrium of fertile and infertile women: A prospective observational casecontrol study.

Identification of microRNA-mRNA interactions in atrial fibrillation using microarray expression profiles and bioinformatics analysis.

Ampelopsin suppresses TNF- -induced migration and invasion of U2OS osteosarcoma cells.

Apoptotic effects of extract from Cnidium monnieri (L.) Cusson by adenosine monosphosphate-activated protein kinase-independent pathway in HCT116 colon cancer cells.

Effects of Tanshinone IIA on the modulation of miR33a and the SREBP2/Pcsk9 signaling pathway in hyperlipidemic rats.

Circulating microRNAs as biomarkers for the early diagnosis of childhood tuberculosis infection.

Metformin induces apoptosis by microRNA-26a-mediated downregulation of myeloid cell leukaemia-1 in human oral cancer cells.

Hyperoside protects human primary melanocytes against H2O2-induced oxidative damage.

16 , 17 -epoxypregnenolone-20-oxime inhibits NO and IL-6 production in LPS-treated RAW264.7 cells.

Effects of Per2 overexpression on growth inhibition and metastasis, and on MTA1, nm23-H1 and the autophagy-associated PI3K/PKB signaling pathway in nude mice xenograft models of ovarian cancer.

Upregulation of microRNA337 promotes the proliferation of endometrial carcinoma cells via targeting PTEN.

Psoralen reverses the P-glycoprotein-mediated multidrug resistance in human breast cancer MCF-7/ADR cells.

Comparison of molecular mechanisms of rheumatoid arthritis and osteoarthritis using gene microarrays.

Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis.

MicroRNA-15b suppresses the growth and invasion of glioma cells through targeted inhibition of cripto-1 expression.

Calcitonin gene-related peptide promotes the expression of osteoblastic genes and activates the WNT signal transduction pathway in bone marrow stromal stem cells.

Paeonol enhances thrombus recanalization by inducing vascular endothelial growth factor 165 via ERK1/2 MAPK signaling pathway.

Lipid droplet-associated proteins in atherosclerosis (Review).

Sequence analysis of the L protein of the Ebola 2014 outbreak: Insight into conserved regions and mutations.

Spot14/Spot14R expression may be involved in MSC adipogenic differentiation in patients with adolescent idiopathic scoliosis.

Silencing of RTKN2 by siRNA suppresses proliferation, and induces G1 arrest and apoptosis in human bladder cancer cells.

MicroRNA-205 suppresses the invasion and epithelial-mesenchymal transition of human gastric cancer cells.

Knockdown by shRNA identifies SLC44A5 as a potential therapeutic target in hepatocellular carcinoma.

An R1632C variant in the SCN5A gene causing Brugada syndrome.

Thrombosis recanalization by paeoniflorin through the upregulation of urokinasetype plasminogen activator via the MAPK signaling pathway.

Overexpression of PDZK1IP1, EEF1A2 and RPL41 genes in intrahepatic cholangiocarcinoma.

Attenuation of renal ischemia/reperfusion injury by oleanolic acid preconditioning via its antioxidant, antiinflammatory, and antiapoptotic activities.

Propofol depresses cisplatin cytotoxicity via the inhibition of gap junctions.

Cannabinoid WIN-55,212-2 mesylate inhibits ADAMTS-4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan-1

MicroRNA-22 is downregulated in clear cell renal cell carcinoma, and inhibits cell growth, migration and invasion by targeting PTEN.

Tumorigenesis of nuclear transfer-derived embryonic stem cells is reduced through differentiation and enrichment following transplantation in the infarcted rat heart.

Role of peroxiredoxin 2 in H2O2induced oxidative stress of primary Leydig cells.

Bruton's tyrosine kinase inhibitor restrains Wnt signaling in chronic lymphocytic leukemia.

The herbal extract KCHO-1 exerts a neuroprotective effect by ameliorating oxidative stress via heme oxygenase-1 upregulation.

Integration of gene expression and DNA methylation profiles provides a molecular subtype for risk assessment in atherosclerosis.

DNase I aggravates islet ß-cell apoptosis in type 2 diabetes.

LXR agonist T0901317 upregulates thrombomodulin expression in glomerular endothelial cells by inhibition of nuclear factorκB.

Src/STAT3 signaling pathways are involved in KAI1-induced downregulation of VEGF-C expression in pancreatic cancer.

Herbal medicine Ganfukang downregulates Wnt/Ca2+ signaling to attenuate liver fibrogenesis in vitro and in vivo.

Continuous evaluation of changes in the serum proteome from early to late stages of sepsis caused by Klebsiella pneumoniae.

[Retracted] Retinoic acidincorporated glycol chitosan nanoparticles inhibit the expression of Ezh2 in U118 and U138 human glioma cells.

Geranylgeranylacetone alleviates radiation-induced lung injury by inhibiting epithelial-to-mesenchymal transition signaling.

Ginsenoside Rg1 ameliorates hippocampal long-term potentiation and memory in an Alzheimer's disease model.

Hedgehog gene polymorphisms are associated with the risk of Hirschsprung's disease and anorectal malformation in a Chinese population.

Ursolic acid protects against ulcerative colitis via anti-inflammatory and antioxidant effects in mice.

TLR2/NFκB signalling regulates endogenous IL-6 release from marrow-derived mesenchymal stromal cells to suppress the apoptosis of PC12 cells injured by oxygen and glucose deprivation.

Changes in mesenchymal stem cells following long-term culture in vitro.

HCV core protein-induced upregulation of microRNA-196a promotes aberrant proliferation in hepatocellular carcinoma by targeting FOXO1.

Knockdown of RHOC by shRNA suppresses invasion and migration of cholangiocellular carcinoma cells via inhibition of MMP2, MMP3, MMP9 and epithelial-mesenchymal transition.

MicroRNA-126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma.

Oleanolic acid inhibits colorectal cancer angiogenesis in vivo and in vitro via suppression of STAT3 and Hedgehog pathways.

Upregulation of TRPM7 augments cell proliferation and interleukin-8 release in airway smooth muscle cells of rats exposed to cigarette smoke.

Ursolic acid prevents augmented peripheral inflammation and inflammatory hyperalgesia in high-fat diet-induced obese rats by restoring downregulated spinal PPAR .

Effects of tripterygium glycosides on restenosis following endovascular treatment.

p.D1690N sodium voltage-gated channel subunit 5 mutation reduced sodium current density and is associated with Brugada syndrome.

Vascular endothelial growth factor induces antiMüllerian hormone receptor 2 overexpression in ovarian granulosa cells of in vitro fertilization/intracytoplasmic sperm injection patients.

Ibuprofen attenuates nephropathy in streptozotocininduced diabetic rats.

Apelin-13 protects against myocardial infarction-induced myocardial fibrosis.

Synergistically increased ILC2 and Th9 cells in lung tissue jointly promote the pathological process of asthma in mice.

Effects of bone marrow mesenchymal stem cells on the cardiac function and immune system of mice with endotoxemia.

Ketamine attenuates osteoarthritis of the knee via modulation of inflammatory responses in a rabbit model.

Cordyceps militaris induces tumor cell death via the caspasedependent mitochondrial pathway in HepG2 and MCF7 cells.

Paclitaxel inhibits selenoprotein S expression and attenuates endoplasmic reticulum stress.

NIBP impacts on the expression of E-cadherin, CD44 and vimentin in colon cancer via the NF-κB pathway.

CD4+ T cell responses in Balb/c mice with food allergy induced by trinitrobenzene sulfonic acid and ovalbumin.

Post-translational modifications of -synuclein contribute to neurodegeneration in the colon of elderly individuals.

Preparation and performance of a pH-sensitive cisplatin-loaded magnetic nanomedicine that targets tumor cells via folate receptor mediation.

Astragaloside IV prevents high glucose-induced podocyte apoptosis via downregulation of TRPC6.

Combined treatment with vitamin E and gefitinib has synergistic effects to inhibit TGF-ß1-induced renal fibroblast proliferation.

Knockdown of versican V1 induces a severe inflammatory response in LPS-induced acute lung injury via the TLR2-NF-κB signaling pathway in C57BL/6J mice.

Effects of p53 on aldosterone-induced mesangial cell apoptosis in vivo and in vitro.

Association between microRNA polymorphisms and the risk of inflammatory bowel disease.

Transplantation of ovarian granulosalike cells derived from human induced pluripotent stem cells for the treatment of murine premature ovarian failure.

Simvastatin ameliorates ventricular remodeling via the TGFß1 signaling pathway in rats following myocardial infarction.

Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells.

MicroRNA451 protects against cardiomyocyte anoxia/reoxygenation injury by inhibiting high mobility group box 1 expression.

CXCL12/CXCR4 axis regulates neovascularization and lymphangiogenesis in sutured corneas in mice.

Tumor suppressor miR-149-5p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma.

Adenovirus encoding XAF-1 and TNF in the same open reading frame efficiently inhibits hepatocellular cancer cells.

Sequential changes of endoplasmic reticulum stress and apoptosis in myocardial fibrosis of diabetes mellitus-induced rats.

MicroRNA143 targets CD44 to inhibit breast cancer progression and stem cell-like properties.

Microsatellite polymorphism in the P1 promoter region of the IGF-1 gene is associated with endometrial cancer

Production of interleukin4 in CD133+ cervical cancer stem cells promotes resistance to apoptosis and initiates tumor growth.

Indirect coculture of vascular smooth muscle cells with bone marrow mesenchymal stem cells inhibits vascular calcification and downregulates the Wnt signaling pathways.

Critical role of oncogenic KRAS in pancreatic cancer (Review).

TRIM59 is upregulated and promotes cell proliferation and migration in human osteosarcoma.

Identification of TLR2 and TLR4induced microRNAs in human mesenchymal stem cells and their possible roles in regulating TLR signals.

Expression and clinical significance of aquaglyceroporins in human hepatocellular carcinoma.

Effects of ophiopogonin B on the proliferation and apoptosis of SGC7901 human gastric cancer cells.

Roles of SHARP1 in thyroid cancer.

Chronic effects of soft drink consumption on the health state of Wistar rats: A biochemical, genetic and histopathological study.

Pselectin increases angiotensin IIinduced cardiac inflammation and fibrosis via platelet activation.

Quantitative analysis of gene expression in fixed colorectal carcinoma samples as a method for biomarker validation.

Tetrandrine suppresses ßglucaninduced macrophage activation via inhibiting NFκB, ERK and STAT3 signaling pathways.

Neuroprotective effects of resveratrol against traumatic brain injury in rats: Involvement of synaptic proteins and neuronal autophagy.

Rhizoma Dioscoreae extract protects against alveolar bone loss by regulating the cell cycle: A predictive study based on the proteinprotein interaction network.

Role of RANKL in the regulation of NFATc1 and cSrc mRNA expression in osteoclastlike cells.

MicroRNA-199a-5p inhibits tumor proliferation in melanoma by mediating HIF-1 .

Heme oxygenase1 protects H2O2insulted glomerular mesangial cells from excessive autophagy.

HAT inhibitor, garcinol, exacerbates lipopolysaccharideinduced inflammation in vitro and in vivo.

Shensong Yangxin capsules prevent ischemic arrhythmias by prolonging action potentials and alleviating Ca2+ overload.

Elevated RNA expression of long noncoding HOTAIR promotes cell proliferation and predicts a poor prognosis in patients with diffuse large B cell lymphoma.

Year: 2016 Volume: 13 Issue: 5

Year: 2016 Volume: 13 Issue: 4

Year: 2016 Volume: 13 Issue: 3

Year: 2016 Volume: 13 Issue: 2

Year: 2016 Volume: 13 Issue: 1

Year: 2015 Volume: 12

Year: 2015 Volume: 11

Year: 2014 Volume: 10

Year: 2014 Volume: 9

Year: 2013 Volume: 8

Year: 2013 Volume: 7

Year: 2012 Volume: 6

Year: 2012 Volume: 5

Year: 2011 Volume: 4

Year: 2010 Volume: 3

Year: 2008 Volume: 1

Thrombosis recanalization by paeoniflorin through the upregulation of urokinasetype plasminogen activator via the MAPK signaling pathway.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hou, Junran Ye, Songshan Yang, Lei Mao, Bingyu Fu, Weiyun
Description	Author Affiliation: Ye S ( Department of Medical Experimental Center, Zhang Zhongjing Traditional Chinese Medicine College, Nanyang Institute of Technology, Nanyang, Henan 473004, P.R. China.); Mao B ( Department of Medical Experimental Center, Zhang Zhongjing Traditional Chinese Medicine College, Nanyang Institute of Technology, Nanyang, Henan 473004, P.R. China.); Yang L ( Department of Medical Experimental Center, Zhang Zhongjing Traditional Chinese Medicine College, Nanyang Institute of Technology, Nanyang, Henan 473004, P.R. China.); Fu W ( Department of Medical Experimental Center, Zhang Zhongjing Traditional Chinese Medicine College, Nanyang Institute of Technology, Nanyang, Henan 473004, P.R. China.); Hou J ( Department of Medical Experimental Center, Zhang Zhongjing Traditional Chinese Medicine College, Nanyang Institute of Technology, Nanyang, Henan 473004, P.R. China.)
Abstract	Paeoniflorin, the major component of Paeonia lactiflora pall, has previously been reported to prevent thrombosis. Plasminogen activator urokinase (uPA) is a serine protease that markedly facilitates normal thrombosis resolution. Paeoniflorin and uPA have been linked to the mitogenactivated protein kinase (MAPK) signaling pathway. In the current study, the influence of paeoniflorin on the expression of uPA was investigated and the underlying regulatory mechanism was preliminarily determined. The prothrombotic state of the model animals treated with paeoniflorin were assessed by enzymelinked immunosorbent assay (ELISA). Additionally, the cytotoxicity of paeoniflorin on human umbilical vein endothelial cell (HUVEC) cultures was estimated using a methyl thiazolyl tetrazolium assay and the possible pathways involved in the interaction between paeoniflorin and uPA were evaluated using western blot analysis. The ELISA results demonstrated that the levels of 6keto prostaglandin F1a, fibronectin and uPA were significantly upregulated by treatment with paeoniflorin compared with control (P<0.05). By contrast, the expression of fibrinogen, Ddimer and thromboxane B2 were inhibited. With an increase in the concentration of paeoniflorin the cell viability of HUVECs decreased gradually. The results of western blot analysis demonstrated that paeoniflorin increased the phosphorylation of MAPK 14 (p38) and MAPK 8 (JNK). The present study demonstrated that paeoniflorin has the potential to improve the prethrombotic state and recanalize thrombosis by increasing the expression of uPA, which may be mediated via regulation of the p38 and JNK MAPK signaling pathways. However, this treatment effect was dependent on the concentration of paeoniflorin used, an unsuitable concentration of the agent would result in a negative effect on the antithrombosis pathways.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2016.5146
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	13
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-06-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in