| Author |
Xie, Min-Qiang Ma, Dong Zhang, Hong-Zheng Wan, Liang-Cai Chen, Shuai-Jun Jiang, Shan-Shan Xu, Yi-Ming Liu, Fang Zhang, Tao |
| Description |
Author Affiliation: Chen SJ ( Department of Otolaryngology Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China.); Zhang HZ ( Department of Otolaryngology Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China.); Wan LC ( Department of Otolaryngology Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China.); Jiang SS ( Department of Otolaryngology Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China.); Xu YM ( Department of Otolaryngology Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China.); Liu F ( Department of Otolaryngology Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China.); Zhang T ( Department of Otolaryngology Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China.); Ma D ( Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, P.R. China.); Xie MQ ( Department of Otolaryngology Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China.) |
| Abstract |
The present study aimed to prepare cisplatin (CDDP)-loaded magnetic nanoparticles (MNPs), which target folate receptors via a pH-sensitive release system (FAPEGNHN=MNPsCDDP). This is of interest for the development of intelligent drug delivery systems that target tumors of the head and neck. The chemical coprecipitation method was used to prepare ferroferric oxide MNPs. These were modified with aldehyde sodium alginate complexed with the chemotherapeutic agent, CDDP on the surface of the nanoparticles. Double hydrazinepoly(ethylene glycol; PEG) was also prepared by attaching the carboxyl group of hydrazinefolate on one side of the double hydrazinePEG, obtaining folatehydrazinePEGdiazenyl. This binds the aldehyde group of sodium alginic acid on the MNP to enclose CDDP, in order that it is sequestered within the carrier. This method obtained a pHsensitive, FAmodified CDDPloaded MNP (FAPEGNHN=MNPsCDDP), which acts as an intelligent tumor targeting drug delivery system. The mean size of the MNPs was ~10.2±1.5 nm, the mean hydrodynamic diameter detected by laser particle sizing instruments was 176.6±1.1 nm, and the ζpotential was 20.91±1.76 mV. The CDDP content was 0.773 mg/ml, the iron content was ~1.908 mg/ml and the maximum saturation magnetization was 16.3±0.2 emu/g. The current study produced a pHsensitive FAmodified CDDPloaded MNP that is stable and exhibits magnetic responsiveness, which releases CDDP in a low pH environment. |
