NDLI: Neuroprotective effect of ginsenoside Rg1 prevents cognitive impairment induced by isoflurane anesthesia in aged rats via antioxidant, anti-inflammatory and anti-apoptotic effects mediated by the PI3K/AKT/GSK-3ß pathway.

Please wait, while we are loading the content...

Year: 2017 Volume: 15

Year: 2016 Volume: 14

Year: 2016 Volume: 14 Issue: 6

Year: 2016 Volume: 14 Issue: 5

Year: 2016 Volume: 14 Issue: 4

Year: 2016 Volume: 14 Issue: 3

mRNA expression of TLR4, TLR9 and NF-κB in a neonatal murine model of necrotizing enterocolitis.

Suppression of tumor cell proliferation by quinine via the inhibition of the tumor necrosis factor receptorassociated factor 6AKT interaction.

Identifying the role of Wilms tumor 1 associated protein in cancer prediction using integrative genomic analyses.

The effect of LOXL2 in hepatocellular carcinoma.

Aspirin inhibits osteoclastogenesis by suppressing the activation of NF-κB and MAPKs in RANKL-induced RAW264.7 cells.

B7-H4 expression in human infiltrating ductal carcinomaassociated macrophages.

Prenatal valproate treatment produces autistic-like behavior and increases metabotropic glutamate receptor 1A-immunoreactivity in the hippocampus of juvenile rats.

Functional expression of human 7 nicotinic acetylcholine receptor in human embryonic kidney 293 cells.

Inhibition of multiple myeloma cell proliferation by ginsenoside Rg3 via reduction in the secretion of IGF-1.

Endothelial lipase is upregulated by interleukin-6 partly via the p38 MAPK and p65 NF-κB signaling pathways.

Differential proteomics of the synovial membrane between bilateral and unilateral knee osteoarthritis in surgeryinduced rabbit models.

Dynamic metabolic profiling of urine biomarkers in rats with alcoholinduced liver damage following treatment with ZhiZiDaHuang decoction.

Potential use of visible and near-infrared spectroscopy for the analysis and diagnosis of chronic fatigue syndrome (Review).

Association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and susceptibility to Graves' ophthalmopathy.

Emodin8Oglucuronic acid, from the traditional Chinese medicine qinghuobaiduyin, affects the secretion of inflammatory cytokines in LPSstimulated raw 264.7 cells via HSP70.

Generation of porcine fetal fibroblasts expressing the tetracycline-inducible Cas9 gene by somatic cell nuclear transfer

Protective effect of cannabidiol on hydrogen peroxideinduced apoptosis, inflammation and oxidative stress in nucleus pulposus cells.

miRNA polymorphisms (miR146a, miR149, miR196a2 and miR499) are associated with the risk of coronary artery disease.

Effects of imatinib and nilotinib on the whole transcriptome of cultured murine osteoblasts.

Vitamin D induces autophagy of pancreatic ß-cells and enhances insulin secretion.

Antioxidant effect of angiotensin (1-7) in the protection of pancreatic β cell function

Cytotoxic effects of NFκB inhibitors in combination with antiherpes agents on EpsteinBarr viruspositive gastric carcinoma in vitro.

microRNA-7 regulates cell growth, migration and invasion via direct targeting of PAK1 in thyroid cancer.

Apigenin inhibits glioma cell growth through promoting microRNA-16 and suppression of BCL-2 and nuclear factor-κB/MMP9.

Pioglitazone affects the OPG/RANKL/RANK system and increase osteoclastogenesis.

Rescued expression of WIF-1 in gallbladder cancer inhibits tumor growth and induces tumor cell apoptosis with altered expression of proteins.

Molecular analysis of FGFR 2 and associated clinical observations in two Chinese families with Crouzon syndrome.

Caveolin-1 is critical in the proliferative effect of leptin on osteoblasts through the activation of Akt.

Confirming an integrated pathology of diabetes and its complications by molecular biomarker-target network analysis.

Upregulation of kallikreinrelated peptidase 5 is associated with the malignant behavior of colorectal cancer.

Combined therapeutic effects of bortezomib and anacardic acid on multiple myeloma cells via activation of the endoplasmic reticulum stress response.

Paeoniflorin inhibits proliferation and promotes apoptosis of multiple myeloma cells via its effects on microRNA29b and matrix metalloproteinase2.

A novel in-frame deletion in MEN1 (p.Ala416del) causes familial multiple endocrine neoplasia type 1 with an aggressive phenotype and unexpected inheritance pattern.

Aberrant expression of anaplastic lymphoma kinase in lung adenocarcinoma: Analysis of circulating free tumor RNA using one-step reverse transcription-polymerase chain reaction.

Luteolin decreases the UVAinduced autophagy of human skin fibroblasts by scavenging ROS.

Endostatin and irradiation modifies the activity of ADAM10 and neprilysin in breast cancer cells.

Dynamic co-expression network analysis of lncRNAs and mRNAs associated with venous congestion.

Slit2Robo1 signaling promotes the adhesion, invasion and migration of tongue carcinoma cells via upregulating matrix metalloproteinases 2 and 9, and downregulating Ecadherin.

A single nucleotide polymorphism in hsamiR146a is responsible for the development of bronchial hyperresponsiveness in response to intubation during general anesthesia.

Protection of rat liver against hepatic ischemia-reperfusion injury by a novel selenocysteine-containing 7-mer peptide.

Enhanced expression levels of aquaporin-1 and aquaporin-4 in A549 cells exposed to silicon dioxide.

The antidengue virus properties of statins may be associated with alterations in the cellular antiviral profile expression.

Plateletrich plasma promotes the migration and invasion of synovial fibroblasts in patients with rheumatoid arthritis.

rs78378222 polymorphism in the 3'-untranslated region of TP53 contributes to development of age-associated cataracts by modifying microRNA-125b-induced apoptosis of lens epithelial cells.

Evaluation of urinary bladder fibrogenesis in a mouse model of long-term ketamine injection.

The expression pattern of Adam10 in the central nervous system of adult mice: Detection by in situ hybridization combined with immunohistochemistry staining.

Alteration of the immune status of umbilical cord mesenchymal stem cells stimulated by TLR1/2 agonist, Pam3Csk.

Sevoflurane inhibits the self-renewal of mouse embryonic stem cells via the GABAAR-ERK signaling pathway.

Quantitative PCR marker genes for endometrial adenocarcinoma.

Dickkopf 2 promotes proliferation and invasion via Wnt signaling in prostate cancer.

Hypermethylation of CDH13, DKK3 and FOXL2 promoters and the expression of EZH2 in ovary granulosa cell tumors.

Identification of a novel frameshift heterozygous deletion in exon 8 of the PAX6 gene in a pedigree with aniridia.

Silencing of osterix expression by siRNA inhibits aldosteroneinduced calcification of vascular smooth muscle cells in mice.

Targeted next-generation sequencing identification of a novel missense mutation of the SKIV2L gene in a patient with trichohepatoenteric syndrome.

In vitro and in vivo anti-Vibrio vulnificus activity of psammaplin A, a natural marine compound.

Effects of irreversible electroporation on cervical cancer cell lines in vitro.

Investigation of the antiasthmatic activity of Oridonin on a mouse model of asthma.

Role of platelet function and platelet membrane glycoproteins in children with primary immune thrombocytopenia.

miRNA-30a functions as a tumor suppressor by downregulating cyclin E2 expression in castration-resistant prostate cancer.

Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease.

Identification of two novel mutations in the COMP gene in six families with pseudoachondroplasia.

Differential long noncoding RNA and mRNA expression in differentiated human glioblastoma stem cells.

Tumorigenic lung tumorospheres exhibit stem-like features with significantly increased expression of CD133 and ABCG2.

Increased protein expression levels of pCREB, BDNF and SDF-1/CXCR4 in the hippocampus may be associated with enhanced neurogenesis induced by environmental enrichment.

HIV1 downregulates the expression and phosphorylation of receptor tyrosine kinase by targeting the NFκB pathway.

-TEA inhibits the growth and motility of human colon cancer cells via targeting RhoA/ROCK signaling.

Bufalin suppresses cancer stem-like cells in gemcitabine-resistant pancreatic cancer cells via Hedgehog signaling.

Effects of microRNA3383p on morphineinduced apoptosis and its underlying mechanisms.

Zisheng Shenqi decoction ameliorates monosodium urate crystal-induced gouty arthritis in rats through anti-inflammatory and anti-oxidative effects.

microRNA-199a-3p functions as tumor suppressor by regulating glucose metabolism in testicular germ cell tumors.

Expression and clinical significance of Apollon in esophageal squamous cell carcinoma.

Increased levels of circulating adrenomedullin following treatment with TU100 in patients with Crohn's disease.

Application of network construction to estimate functional changes to insulin receptor substrates 1 and 2 in Huh7 cells following infection with the hepatitis C virus.

Directed differentiation of postnatal hippocampal neural stem cells generates nuclear receptor related1 protein and tyrosine hydroxylaseexpressing cells.

Antimigratory effect of rapamycin impairs allograft imaging by 18Ffluorodeoxyglucoselabeled splenocytes.

Disruption of kif3a results in defective osteoblastic differentiation in dental mesenchymal stem/precursor cells via the Wnt signaling pathway.

Berberine enhances the antitumor activity of tamoxifen in drugsensitive MCF7 and drugresistant MCF7/TAM cells.

A novel manganese complex selectively induces malignant glioma cell death by targeting mitochondria.

Inhibitor of DNA binding 1 regulates cell cycle progression of endothelial progenitor cells through induction of Wnt2 expression.

Angiopoietin-like protein 2 expression is suppressed by angiotensin II via the angiotensin II type 1 receptor in rat cardiomyocytes.

Wnt3a is critical for endothelial progenitor cell-mediated neural stem cell proliferation and differentiation.

The protective role of vitamin D3 in a murine model of asthma via the suppression of TGF-ß/Smad signaling and activation of the Nrf2/HO-1 pathway.

Functional study of the upregulation of miRNA-27a and miRNA-27b in 3T3-L1 cells in response to berberine.

The clinical significance of forkhead box protein A1 and its role in colorectal cancer.

Atorvastatin ameliorates endothelium-specific insulin resistance induced by high glucose combined with high insulin.

Peripheral KATP activation inhibits pain sensitization induced by skin/muscle incision and retraction via the nuclear factor-κB/c-Jun N-terminal kinase signaling pathway.

Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis

Expression of interferon regulatory factor 5 is regulated by the Sp1 transcription factor.

Identification of a PTPN11 hot spot mutation in a child with atypical LEOPARD syndrome.

miR-22-5p revealed as a potential biomarker involved in the acute phase of myocardial infarction via profiling of circulating microRNAs.

Mild CamuratiEngelamann disease presenting with exophthalmos as the first and only manifestation: A case report.

Proteomic analysis of the effects of CSF-1 and IL-1 on dental follicle cells.

Periodic mechanical stress induces the extracellular matrix expression and migration of rat nucleus pulposus cells by upregulating the expression of intergrin 1 and phosphorylation of downstream phospholipase CÎ³1.

Semaphorin 3A-modified adipose-derived stem cell sheet may improve osseointegration in a type 2 diabetes mellitus rat model.

Wtip is required for proepicardial organ specification and cardiac left/right asymmetry in zebrafish.

Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation.

Modulatory effects of levamisole and garlic oil on the immune response of Wistar rats: Biochemical, immunohistochemical, molecular and immunological study.

Celastrol inhibits IL-1ß-induced inflammation in orbital fibroblasts through the suppression of NF-κB activity.

Co-expression of ING4 and P53 enhances hypopharyngeal cancer chemosensitivity to cisplatin in vivo.

Effects of cisplatin on the LSD1-mediated invasion and metastasis of prostate cancer cells.

CIP2A regulates proliferation and apoptosis of multiple myeloma cells.

LncRNA HOTAIR controls the expression of Rab22a by sponging miR-373 in ovarian cancer.

Resveratrol inhibits phosphorylation within the signal transduction and activator of transcription 3 signaling pathway by activating sirtuin 1 in SW1353 chondrosarcoma cells.

Therapeutic effects of paeonol on methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid-induced Parkinson's disease in mice.

Cerebral vasoconstriction reactions and plasma levels of ETBR, ET-1, and eNOS in patients with chronic high altitude disease.

MicroRNA-26a protects against cardiac hypertrophy via inhibiting GATA4 in rat model and cultured cardiomyocytes.

Neuroprotective effect of ginsenoside Rg1 prevents cognitive impairment induced by isoflurane anesthesia in aged rats via antioxidant, anti-inflammatory and anti-apoptotic effects mediated by the PI3K/AKT/GSK-3ß pathway.

MicroRNA-101 inhibits the proliferation and invasion of bladder cancer cells via targeting c-FOS.

Effect of evodiamine on the proliferation and apoptosis of A549 human lung cancer cells.

Molecular analysis of myocilin and optineurin genes in Korean primary glaucoma patients.

Protective effects of ghrelin against oxidative stress, inducible nitric oxide synthase and inflammation in a mouse model of myocardial ischemia/reperfusion injury via the HMGB1 and TLR4/NF-κB pathway.

Neuroprotection induced by post-conditioning following ischemia/reperfusion in mice is associated with altered microRNA expression.

Immunomodulatory effects of Longdan Xiegan Tang on CD4+/CD8+ T cells and associated inflammatory cytokines in rats with experimental autoimmune uveitis.

Loss of coxsackie and adenovirus receptor expression in human colorectal cancer: A potential impact on the efficacy of adenovirus-mediated gene therapy in Chinese Han population.

Nitidine chloride inhibits proliferation, induces apoptosis via the Akt pathway and exhibits a synergistic effect with doxorubicin in ovarian cancer cells.

Umbilical cord-derived mesenchymal stem cells inhibit growth and promote apoptosis of HepG2 cells.

MicroRNA-610 is downregulated in glioma cells, and inhibits proliferation and motility by directly targeting MDM2.

MicroRNA-363 and GATA-1 are regulated by HIF-1 in K562 cells under hypoxia.

Resistant mechanisms and molecular epidemiology of imipenem-resistant Acinetobacter baumannii.

Downregulation of AATK mediates microRNA-558-induced resistance of A549 cells to radiotherapy.

Elevated DRD4 promoter methylation increases the risk of Alzheimer's disease in males.

Dysregulated function of normal human epidermal keratinocytes in the absence of filaggrin.

Downregulation of thrombospondin-1 by DNA hypermethylation is associated with tumor progression in laryngeal squamous cell carcinoma.

Synergy between von Hippel-Lindau and P53 contributes to chemosensitivity of clear cell renal cell carcinoma.

Telocytes as potential targets in a cyclophosphamide-induced animal model of premature ovarian failure.

Photoprotective properties of 20(S)-protopanaxatriol, an aglycone of ginseng saponins: Protection from ultraviolet-B radiation-induced oxidative stress in human epidermal keratinocytes.

Low-dose testosterone alleviates vascular damage caused by castration in male rats in puberty via modulation of the PI3K/AKT signaling pathway.

Co-expression of autophagic markers following photodynamic therapy in SW620 human colon adenocarcinoma cells.

Neuregulin-1 (Nrg1) signaling has a preventive role and is altered in the frontal cortex under the pathological conditions of Alzheimer's disease

The pro-oxidant gene p66shc increases nicotine exposure-induced lipotoxic oxidative stress in renal proximal tubule cells.

Year: 2016 Volume: 14 Issue: 2

Year: 2016 Volume: 14 Issue: 1

Year: 2016 Volume: 13

Year: 2015 Volume: 12

Year: 2015 Volume: 11

Year: 2014 Volume: 10

Year: 2014 Volume: 9

Year: 2013 Volume: 8

Year: 2013 Volume: 7

Year: 2012 Volume: 6

Year: 2012 Volume: 5

Year: 2011 Volume: 4

Year: 2010 Volume: 3

Year: 2008 Volume: 1

Neuroprotective effect of ginsenoside Rg1 prevents cognitive impairment induced by isoflurane anesthesia in aged rats via antioxidant, anti-inflammatory and anti-apoptotic effects mediated by the PI3K/AKT/GSK-3ß pathway.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zheng, Shaoqiang Zhang, Wei Wang, Haitang Zhang, Yini Zhou, Shuang Zhang, Zhao Zhao, Yaoping Si, Qi Cai, Nan Chen, Xue
Description	Author Affiliation: Zhang Y ( Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing 100035, P.R. China.); Zhang Z ( Beidaihe Sanatorium of Beijing Military Command, Qinhuangdao, Hebei 066000, P.R. China.); Wang H ( Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.); Cai N ( Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing 100035, P.R. China.); Zhou S ( Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing 100035, P.R. China.); Zhao Y ( Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing 100035, P.R. China.); Chen X ( Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing 100035, P.R. China.); Zheng S ( Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing 100035, P.R. China.); Si Q ( Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing 100035, P.R. China.); Zhang W ( Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing 100035, P.R. China.)
Abstract	Ginsenoside Rg1 is the primary active substance in ginseng, and it has multiple pharmacological actions. Investigations on the pharmacologic action of ginsenoside Rg1 have developed, with a particular focus on the regulation of metabolism. The present study hypothesized that the neuroprotective effects of ginsenoside Rg1 prevent cognitive impairment induced by isoflurane anesthesia via antioxidant, antiinflammatory and antiapoptotic effects, mediated by the phosphoinositide 3kinase (PI3K)/AKT/glycogen synthase kinase3ß (GSK3ß) pathway in aged rats. SpragueDawley rats were divided into isoflurane and ginsenoside Rg1 groups and were treated with 20 mg/kg ginsenoside Rg1 for 7 days. Morris water maze was performed to analyze the cognitive function of the rats. Enzymelinked immunosorbent assays were used to analyze the levels of malondialdehyde, glutathione, interleukin (IL)1ß, IL6 and caspase 3. The protein expression levels of AKT, GSK 3ß, p21WAF1/CIP1 and p53 were measured using western blot analysis. Ginsenoside Rg1 significantly improved cognitive function, and exhibited antioxidant and antiinflammatory effects, demonstrating the neuroprotective effects of ginsenoside Rg1 against the effect of isoflurane anesthesia in the rats. In addition, ginsenoside Rg1 significantly reduced caspase3 activity, upregulated the expression of PI3K/AKT/GSK3ß and downregulated the mRNA expression levels of p21WAF1/CIP1 and p53 in the aged rats exposed to isoflurane anesthesia. The data obtained in the present study provided evidence that the neuroprotective effects of ginsenoside Rg1 prevented the cognitive impairment induced by isoflurane anesthesia via antioxidant, antiinflammatory and antiapoptotic effects, mediated by the PI3K/AKT/GSK3ß pathway.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	14
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-09-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in