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Lipid droplet-associated proteins in atherosclerosis (Review).

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MicroRNA-205 suppresses the invasion and epithelial-mesenchymal transition of human gastric cancer cells.

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Continuous evaluation of changes in the serum proteome from early to late stages of sepsis caused by Klebsiella pneumoniae.

[Retracted] Retinoic acidincorporated glycol chitosan nanoparticles inhibit the expression of Ezh2 in U118 and U138 human glioma cells.

Geranylgeranylacetone alleviates radiation-induced lung injury by inhibiting epithelial-to-mesenchymal transition signaling.

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Hedgehog gene polymorphisms are associated with the risk of Hirschsprung's disease and anorectal malformation in a Chinese population.

Ursolic acid protects against ulcerative colitis via anti-inflammatory and antioxidant effects in mice.

TLR2/NFκB signalling regulates endogenous IL-6 release from marrow-derived mesenchymal stromal cells to suppress the apoptosis of PC12 cells injured by oxygen and glucose deprivation.

Changes in mesenchymal stem cells following long-term culture in vitro.

HCV core protein-induced upregulation of microRNA-196a promotes aberrant proliferation in hepatocellular carcinoma by targeting FOXO1.

Knockdown of RHOC by shRNA suppresses invasion and migration of cholangiocellular carcinoma cells via inhibition of MMP2, MMP3, MMP9 and epithelial-mesenchymal transition.

MicroRNA-126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma.

Oleanolic acid inhibits colorectal cancer angiogenesis in vivo and in vitro via suppression of STAT3 and Hedgehog pathways.

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Ibuprofen attenuates nephropathy in streptozotocininduced diabetic rats.

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Synergistically increased ILC2 and Th9 cells in lung tissue jointly promote the pathological process of asthma in mice.

Effects of bone marrow mesenchymal stem cells on the cardiac function and immune system of mice with endotoxemia.

Ketamine attenuates osteoarthritis of the knee via modulation of inflammatory responses in a rabbit model.

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Paclitaxel inhibits selenoprotein S expression and attenuates endoplasmic reticulum stress.

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Knockdown of versican V1 induces a severe inflammatory response in LPS-induced acute lung injury via the TLR2-NF-κB signaling pathway in C57BL/6J mice.

Effects of p53 on aldosterone-induced mesangial cell apoptosis in vivo and in vitro.

Association between microRNA polymorphisms and the risk of inflammatory bowel disease.

Transplantation of ovarian granulosalike cells derived from human induced pluripotent stem cells for the treatment of murine premature ovarian failure.

Simvastatin ameliorates ventricular remodeling via the TGFß1 signaling pathway in rats following myocardial infarction.

Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells.

MicroRNA451 protects against cardiomyocyte anoxia/reoxygenation injury by inhibiting high mobility group box 1 expression.

CXCL12/CXCR4 axis regulates neovascularization and lymphangiogenesis in sutured corneas in mice.

Tumor suppressor miR-149-5p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma.

Adenovirus encoding XAF-1 and TNF in the same open reading frame efficiently inhibits hepatocellular cancer cells.

Sequential changes of endoplasmic reticulum stress and apoptosis in myocardial fibrosis of diabetes mellitus-induced rats.

MicroRNA143 targets CD44 to inhibit breast cancer progression and stem cell-like properties.

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Association between microRNA polymorphisms and the risk of inflammatory bowel disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Diangeng Zhu, Min Jin, Meiling Li, Mingyang
Description	Author Affiliation: Zhu M ( Department of Oncology, Division of South Building, Chinese PLA General Hospital, Beijing 100853, P.R. China.); Li D ( Department of Training, Chinese PLA General Hospital, Beijing 100853, P.R. China.); Jin M ( Department of Training, Chinese PLA General Hospital, Beijing 100853, P.R. China.); Li M ( Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, P.R. China.)
Abstract	Common single nucleotide polymorphisms (SNPs) in precursor microRNAs may change their properties via altering the expression of miRNAs, resulting in diverse functional consequences. The present study evaluated the effects of four common SNPs in pro-miRNAs on the risk of inflammatory bowel disease (IBD) and IBDassociated colorectal cancer (IBD-CRC). In a hospital based casecontrol investigation in a Chinese population, 468 patients with IBD and 450 age- and gender-matched healthy subjects were enrolled in the present study. The SNPs were genotyped using a polymerase chain reaction (PCR)-restriction fragment length polymorphism technique. The expression levels of the miRNAs were detected by reverse transcriptionPCR. For rs2910164, the risk of IBD was significantly increased in the GC and CC genotypes. The mean expression levels of mir146a in the CC and GC genotypes were lower, compared with that of the GG genotype. For rs2292832, an increased risk of IBD was detected in the recessive model of the TT genotype, compared with the combination of the CT and CC genotypes. The [T] allele was found to be at increased significantly, with a 1.268fold increased risk of IBD, compared with the [C] allele. The mean expression levele of mir149 expression level in the TT genotype was lower, compared with that of the CC genotype. For rs11614913, the risk of IBDCRC was significantly increased in the CC genotype, compared with the TT genotype. In the dominant model, the CC genotype had a high risk of IBDCRC, compared with the combination of the CT and TT genotypes. These findings suggested that mir-146a rs2910164 and mir149 rs2292832 may be associated with the increased risk of IBD via alterations in the expression levels of miRNAs. Therefore, mir196a rs11614913 may contribute to the progression of IBD-CRC.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	13
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-06-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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