NDLI: CXCL12/CXCR4 axis regulates neovascularization and lymphangiogenesis in sutured corneas in mice.

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CXCL12/CXCR4 axis regulates neovascularization and lymphangiogenesis in sutured corneas in mice.

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CXCL12/CXCR4 axis regulates neovascularization and lymphangiogenesis in sutured corneas in mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, Ping Du, Ling-Ling
Description	Author Affiliation: Du LL ( Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.); Liu P ( Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.)
Abstract	The present study aimed to determine the plausible functional role of chemokine (CXC motif) ligand 12 (CXCL12/chemokine (CXC motif) receptor 4 (CXCR4) in inflammatory corneal hemangiogenesis and lymphangiogenesis in vivo. Corneal hemangiogenesis and lymphangiogenesis were induced by placing an 110 nylon suture in an intrastromal position. The expression levels of the vascular endothelial growth factor (VEGF) family, CXCL12 and CXCR4 in the corneas were investigated in the corneas using reverse transcriptionquantitative polymerase chain reaction and immunohistochemistry. Corneal hemangiogenic and lymphangiogenic responses were assessed by immunofluorescence using specific antibodies against cluster of differentiation 31 and lymphatic vessel endothelial hyaluronan receptor1. Subconjunctival injection of AMD3100 to the sutured corneas was also performed. CXCL12/CXCR4 mRNA and protein expression levels increased markedly in sutureinduced corneal neovascularization (CNV) and decreased with AMD3100 treatment. Hemangiogenesis and lymphangiogenesis were captured in images using immunofluorescence and were shown to be markedly increased with suture placement and reduced with AMD3100 treatment. VEGFA/VEGFR1 and VEGFC/VEGFR3 mRNA expression levels were upregulated in the suture placement and control groups, whereas the expression levels of all the factors were downregulated in the AMD3100 treatment group. The results from the present study demonstrated that CXCL12/CXCR4 interactions regulate hemangiogenesis and lymphangiogenesis in sutureinduced CNV. AMD3100 may be a novel therapeutic target for the prevention of blindness.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2016.5179
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	13
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-06-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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