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Ketamine attenuates osteoarthritis of the knee via modulation of inflammatory responses in a rabbit model.

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Ketamine attenuates osteoarthritis of the knee via modulation of inflammatory responses in a rabbit model.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yao, Jing Lu, Wei Wang, Lin Wo, Chunxin
Description	Author Affiliation: Lu W ( Department of Anesthesiology, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.); Wang L ( Department of Anesthesiology, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.); Wo C ( Department of Anesthesiology, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.); Yao J ( Department of Anesthesiology, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.)
Abstract	The aim of the present study was to investigate the efficacy of ketamine in attenuating osteoarthritis (OA) and modulating the expression of inflammatory mediators. A rabbit OA model was established by knee immobilization using plaster bandages. After six weeks, rabbits were randomly allocated into four groups (n=6/group): Normal saline, Ket60, Ket100, and Ket200 and twice a week for four weeks the rabbits received an intraarticular injection of saline, or 60, 100 or 200 µmol/l ketamine, respectively. One week after the final injection, samples of synovial membrane, synovial fluid and articular cartilage were isolated. The pathological changes were assessed by general observation, hematoxylin and eosin staining and Alcian blue/periodicacid Schiff staining. Cartilage pathology was assessed using Mankin's scoring system. Tumor necrosis factor (TNF) and interleukin (IL)10 levels in the synovial fluid were measured by enzymelinked immunosorbent assays. The nuclear factor (NF)κB p65 subunit expression level in cartilage samples was determined by immunohistochemistry. OA was characterized by morphological changes in the articular surface, cartilage lesions, infiltration of inflammatory cells and a significantly increased Mankin's score. Elevated TNF and reduced IL-10 levels in the synovial fluid, along with increased p65 expression levels in the cartilage were observed in OA rabbits. Intraarticular injection of ketamine ameliorated the pathological characteristics of OA, reduced the Mankin's score, decreased TNF and NFκB p65 expression levels, and increased the level of IL10 expression in a dose-dependent manner. Thus is was demonstrated that Ketamine suppresses the inflammatory response in OA by modulating inflammatory mediator expression levels in a rabbit model of OA.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2016.5164
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	13
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-06-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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