NDLI: Chronic effects of soft drink consumption on the health state of Wistar rats: A biochemical, genetic and histopathological study.

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Chronic effects of soft drink consumption on the health state of Wistar rats: A biochemical, genetic and histopathological study.

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Chronic effects of soft drink consumption on the health state of Wistar rats: A biochemical, genetic and histopathological study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Soliman, Mohamed Mohamed Alshehiri, Zafer Saad Ismail, Tamer Ahmed Salah-Eldin, Alaa-Eldin Attia, Hossam Fouad Alkhedaide, Adel
Description	Country affiliation: Saudi Arabia Author Affiliation: Alkhedaide A ( Department of Medical Laboratories, Faculty of Applied Medical Sciences, Taif 21944, Saudi Arabia.); Soliman MM ( Department of Medical Laboratories, Faculty of Applied Medical Sciences, Taif 21944, Saudi Arabia.); Salah-Eldin AE ( Medical Laboratories Department, College of Science, Majmaah University, Al Zulfi 2345, Saudi Arabia.); Ismail TA ( Department of Medical Laboratories, Faculty of Applied Medical Sciences, Taif 21944, Saudi Arabia.); Alshehiri ZS ( Medical Laboratory Department, College of Applied Medical Sciences, Shaqra University, AlDawadmi 1678, Saudi Arabia.); Attia HF ( Department of Histology, Faculty of Veterinary Medicine, Benha University, Benha 13736, Egypt.)
Abstract	The present study was performed to examine the effects of chronic soft drink consumption (SDC) on oxidative stress, biochemical alterations, gene biomarkers and histopathology of bone, liver and kidney. Free drinking water of adult male Wistar rats was substituted with three different soft drinks: CocaCola, Pepsi and 7Up, for three consecutive months. The serum and organs were collected for examining the biochemical parameters associated with bone, liver and kidney functions. Semiquantitative reverse transcription polymerase chain reaction was used to observe the changes in the expression of genes in the liver and kidney, which are associated with oxidative stress resistance. Histopathological investigations were performed to determine the changes in bone, liver and kidney tissues using hematoxylin and eosin stains. SDC affected liver, kidney and bone function biomarkers. Soft drinks increased oxidative stress, which is represented by an increase in malondialdehyde and a decrease in antioxidant levels. SDC affected serum mineral levels, particularly calcium and phosphorus. Soft drinks downregulated the expression levels of glutathioneStransferase and super oxide dismutase in the liver compared with that of control rats. Rats administered CocaCola exhibited a hepatic decrease in the mRNA expression of 2macroglobulin compared with rats administered Pepsi and 7Up. On the other hand, SDC increased the mRNA expression of 1acid glycoprotein. The present renal studies revealed that CocaCola increased the mRNA expression levels of desmin, angiotensinogen and angiotensinogen receptor compared with the other groups, together with mild congestion in renal histopathology. Deleterious histopathological changes were reported predominantly in the bone and liver of the CocaCola and Pepsi groups. In conclusion, a very strict caution must be considered with SDC due to the increase in oxidative stress biomarkers and disruption in the expression of certain genes associated with the biovital function of both the liver and kidney.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2016.5199
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	13
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-06-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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