NDLI: Peripheral defocus and myopia progression in myopic children randomly assigned to wear single vision and progressive addition lenses.

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Peripheral defocus and myopia progression in myopic children randomly assigned to wear single vision and progressive addition lenses.

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Peripheral defocus and myopia progression in myopic children randomly assigned to wear single vision and progressive addition lenses.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Berntsen, David A. Barr, Christopher D. Zadnik, Karla Mutti, Donald O.
Description	Country affiliation: United States Author Affiliation: Berntsen DA ( University of Houston College of Optometry, Houston, Texas 77204-2020, USA. dberntsen@optometry.uh.edu)
Abstract	PURPOSE: To determine the effect of progressive addition lenses (PALs) and single vision lenses (SVLs) on peripheral defocus in myopic children, and to compare the effect of myopic versus hyperopic peripheral defocus on foveal myopia progression. METHODS: Eighty-four myopic children aged 6 to 11 years with spherical equivalent (SE) cycloplegic autorefraction between -0.75 diopters (D) and -4.50 D were randomly assigned to wear SVLs or PALs. Aberrometry measurements of the eye and spectacles were made centrally, 30° nasally, temporally, and superiorly, and 20° inferiorly on the retina using a Complete Ophthalmic Analysis System for Vision Research (COAS-VR). The association between peripheral defocus and the 1-year change in central myopia was investigated. RESULTS: SVLs caused a hyperopic shift in peripheral defocus at all locations (all P ≤ 0.0003). PALs caused a myopic shift in peripheral defocus in three of four locations measured (all P ≤ 0.01) with the greatest shift superiorly due to the PAL addition (-1.04 ± 0.30 D). Superior retinal defocus when wearing either SVLs or PALs was associated with the 1-year change in central myopia. The adjusted 1-year change in central SE myopia was -0.38 D for children with absolute superior myopic defocus (n = 67) and -0.65 D for children with absolute superior hyperopic defocus (n = 17; difference = 0.27 D; P = 0.002). CONCLUSIONS: PALs caused a myopic shift in peripheral defocus. Superior myopic defocus was associated with less central myopia progression. These data support the continued investigation of optical designs that result in peripheral myopic defocus as a potential way to slow myopia progression. (ClinicalTrials.gov number, NCT00335049.).
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.13-11904
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-08-27
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Eyeglasses Myopia Therapy Visual Fields Physiology Disease Progression Physiopathology Refraction, Ocular Randomized Controlled Trial Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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