NDLI: Clinical relevance of foveal location on retinal nerve fiber layer thickness using the new FoDi software in spectralis optical coherence tomography.

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Clinical relevance of foveal location on retinal nerve fiber layer thickness using the new FoDi software in spectralis optical coherence tomography.

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Clinical relevance of foveal location on retinal nerve fiber layer thickness using the new FoDi software in spectralis optical coherence tomography.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Valverde-Megías, Alicia Serrador-García, Mercedes García-Feijoó, Julián Martinez-de-la-Casa, José M. Larrosa, José Manuel
Description	Country affiliation: Spain Author Affiliation: Valverde-Megías A ( Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. alicia.valgreen@gmail.com)
Abstract	PURPOSE: To evaluate the effect of improper foveal location on retinal nerve fiber layer (RNFL) thickness measurements by using the new FoDi software in spectral-domain optical coherence tomography (Spectralis SDOCT). METHODS: Cross-sectional study with 126 subjects: 66 healthy, 30 early, and 30 moderate glaucomatous eyes. Fast RNFL scans were performed by using the new FoDi technology. The position of the fovea was manually displaced inferiorly after acquisition (producing clockwise torsion of scan circle) and then superiorly (counterclockwise) to generate study sets of images. Differences in RNFL thickness between foveal-guided and alternative scans were analyzed and color changes in sector charts were evaluated. RESULTS: In healthy eyes, placing the fovea inferiorly led to significant RNFL thickness changes in all sectors. Locating the fovea superiorly seemed to have less impact. Early glaucomatous eyes were more susceptible to quantitative changes, but moderate glaucomatous eyes were more susceptible to qualitative changes. CONCLUSIONS: Improper fovea disc alignment when using the FoDi software in Spectralis OCT significantly affected sectoral RNFL thickness measurements and color chart representation. As final report of FoDi analysis does not show the foveal position used, careful acquisition is encouraged, so that results are reliable. Otherwise, this technique can easily be misinterpreted and patients could be misdiagnosed.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-08-27
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Glaucoma Diagnosis Nerve Fibers Pathology Optic Disk Tomography, Optical Coherence Cross-sectional Studies Image Processing, Computer-assisted Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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