NDLI: Lack of association between primary angle-closure glaucoma susceptibility loci and the ocular biometric parameters anterior chamber depth and axial length.

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Lack of association between primary angle-closure glaucoma susceptibility loci and the ocular biometric parameters anterior chamber depth and axial length.

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Lack of association between primary angle-closure glaucoma susceptibility loci and the ocular biometric parameters anterior chamber depth and axial length.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cheng, Ching-Yu Vithana, Eranga N. Jonas, Jost B. Wei, Xin Aung, Tin Nongpiur, Monisha E. Wong, Tien-Yin Xu, Liang Wu, Ren-Yi Zheng, Yingfeng Li, Yang Wang, Ya-Xing Perera, Shamira A. Khor, Chiea-Chuen
Spatial Coverage	Singapore China
Description	Country affiliation: Singapore Author Affiliation: Nongpiur ME ( Singapore Eye Research Institute, Singapore.)
Abstract	PURPOSE: Three susceptibility loci for primary angle-closure glaucoma (PACG) were recently identified: PLEKHA7 rs11024102, COL11A1 rs3753841, and rs1015213 located in the intergenic region between PCMTD1 and ST18. The purpose of this study was to investigate the associations of these loci with the ocular biometric parameters anterior chamber depth (ACD) and axial length (AL). METHODS: Genotype and ocular biometric data were available for four population-based studies, including three from Singapore (Singapore Chinese Eye Study, Singapore Malay Eye Study, and Singapore Indian Eye Study) and one from China (Beijing Eye Study), exceeding 7000 participants. ACD and AL were measured using the IOLMaster for the Singapore cohorts and optical low-coherence reflectometry (Lenstar 900 Optical Biometer) for the Beijing cohort. Five readings were obtained for each participant and the average was computed. Analysis excluded any eye that was pseudophakic or aphakic. RESULTS: ACD measurements and genotype data of the three loci were available for 7245, 7243, and 7239 subjects, respectively. We noted nominal evidence of association between single nucleotide polymorphism (SNP) rs1015213 (PCMTD1-ST18) and a shallower ACD when all data were meta-analyzed (ß = -0.033, P = 0.021). When multiple testing was considered, the observation was nonsignificant. There was no association between ACD and rs11024102 (PLEKHA7) or rs3753841 (COL11A1). We did not observe significant associations between AL and any of the three SNPs. CONCLUSIONS: The lack of association between the PACG susceptibility loci with ACD or AL suggests that predilection to PACG may be mediated by factors other than shallow anterior chamber or short eyeball length.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-08-27
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Anterior Chamber Pathology Axial Length, Eye Carrier Proteins Genetics Collagen Type Xi Glaucoma, Angle-closure Asian Continental Ancestry Group Cohort Studies Cross-sectional Studies Genetic Association Studies Genetic Predisposition To Disease Genotype Ethnology Polymorphism, Single Nucleotide Singapore Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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