NDLI: Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma.

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Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma.

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Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kawaji, Takahiro Inoue, Toshihiro Tanihara, Hidenobu
Description	Country affiliation: Japan Author Affiliation: Inoue T ( Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. noel@da2.so-net.ne.jp)
Abstract	PURPOSE: To investigate levels of biomarkers of Alzheimer's disease in the aqueous humor in patients with open-angle glaucoma (OAG). METHODS: Aqueous humor samples were collected from 38 patients with cataracts, 20 patients with POAG, and 32 patients with exfoliation glaucoma. Aqueous levels of apolipoprotein (Apo) AI, ApoCIII, ApoE, transthyretin (TTR), complement factor H, complement C3, and 2-macroglobulin ( 2M) were determined by multiplex bead immunoassay. Clinical data were obtained from medical charts. RESULTS: Age and sex did not differ significantly among groups. POAG patients had significantly higher aqueous levels of Apo AI, ApoCIII, ApoE, TTR, and 2M compared with cataract patients (P < 0.001, P = 0.036, P < 0.001, P < 0.001, and P < 0.001, respectively). Corresponding values for exfoliation glaucoma patients were also significantly higher compared with those for cataract patients (P = 0.003, P = 0.009, P < 0.001, P < 0.001, and P < 0.001), and those levels correlated positively with each other in eyes with OAG (P < 0.001 for all combinations). Complement factor H and complement C3 levels did not differ among groups. Mean deviation values for the Humphrey visual field test correlated positively with levels of Apo AI, ApoE, TTR, and complement factor H in OAG patients (P = 0.026, 0.012, 0.008, and 0.027, respectively), but age and IOP values were not correlated with protein levels. CONCLUSIONS: OAG patients had elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-08-09
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Alzheimer Disease Metabolism Aqueous Humor Eye Proteins Glaucoma, Open-angle Complications Biological Markers Cross-sectional Studies Disease Progression Enzyme-linked Immunosorbent Assay Severity Of Illness Index Comparative Study Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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