NDLI: IGFBP-3 and TNF- regulate retinal endothelial cell apoptosis.

Please wait, while we are loading the content...

Year: 2017 Volume: 58

Year: 2016 Volume: 57

Year: 2015 Volume: 56

Year: 2014 Volume: 56

Year: 2014 Volume: 55

Year: 2013 Volume: 54

Year: 2013 Volume: 54 Issue: 14

Year: 2013 Volume: 54 Issue: 13

Year: 2013 Volume: 54 Issue: 12

Year: 2013 Volume: 54 Issue: 11

Year: 2013 Volume: 54 Issue: 10

Year: 2013 Volume: 54 Issue: 9

Year: 2013 Volume: 54 Issue: 8

Cone photoreceptor neuroprotection conferred by CNTF in a novel in vivo model of battlefield retinal laser injury.

Fundus autofluorescence in the Abca4(-/-) mouse model of Stargardt disease--correlation with accumulation of A2E, retinal function, and histology.

Predicting the postoperative intraocular lens position using continuous intraoperative optical coherence tomography measurements.

SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity.

The influence of intraocular pressure on wavefront aberrations in patients undergoing laser-assisted in situ keratomileusis.

Anterior segment optical coherence tomography parameters in subtypes of primary angle closure.

Reduction in direction discrimination with age and slow speed is due to both increased internal noise and reduced sampling efficiency.

The PLGA implant as an antimitotic delivery system after experimental trabeculectomy.

Sulforaphane can protect lens cells against oxidative stress: implications for cataract prevention.

Imaging the intact mouse cornea using coherent anti-stokes Raman scattering (CARS).

Age-dependent changes in FasL (CD95L) modulate macrophage function in a model of age-related macular degeneration.

Genomic profile of 320 uveal melanoma cases: chromosome 8p-loss and metastatic outcome.

A prototype hyperspectral system with a tunable laser source for retinal vessel imaging.

Serine protease inhibitor A3K protects rabbit corneal endothelium from barrier function disruption induced by TNF- .

The role of LOX and LOXL2 in scar formation after glaucoma surgery.

Intraocular pressure change over a habitual 24-hour period after changing posture or drinking water and related factors in normal tension glaucoma.

Subjects with unilateral neovascular AMD have bilateral delays in rod-mediated phototransduction activation kinetics and in dark adaptation recovery.

Quantitative changes in perifoveal capillary networks in patients with vascular comorbidities.

Development of a model of elevated intraocular pressure in rats by gene transfer of bone morphogenetic protein 2.

Prospective audit of exudative age-related macular degeneration: 12-month outcomes in treatment-naive eyes.

MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease.

Survey on amacrine cells coupling to retrograde-identified ganglion cells in the mouse retina.

Melting points--the key to the anti-evaporative effect of the tear film wax esters.

New clinical grading scales and objective measurement for conjunctival injection.

Regulation of Cdc42 expression and signaling is critical for promoting corneal epithelial wound healing.

Improved anti-inflammatory effects in rabbit eye model using biodegradable poly beta-amino ester nanoparticles of triamcinolone acetonide.

Corneal nerve structure and function in patients with non-sjogren dry eye: clinical correlations.

Nonlinear, multilevel mixed-effects approach for modeling longitudinal standard automated perimetry data in glaucoma.

A murine model for retinopathy of prematurity identifies endothelial cell proliferation as a potential mechanism for plus disease.

Mutational analysis of MIR184 in sporadic keratoconus and myopia.

Evidence for widespread structural brain changes in glaucoma: a preliminary voxel-based MRI study.

Scanning laser polarimetry, but not optical coherence tomography predicts permanent visual field loss in acute nonarteritic anterior ischemic optic neuropathy.

Prevalence and risk factors for myopia in a rural Korean population.

Interrelationships between maternal carotenoid status and newborn infant macular pigment optical density and carotenoid status.

Peripheral defocus and myopia progression in myopic children randomly assigned to wear single vision and progressive addition lenses.

Variation of lamina cribrosa depth following trabeculectomy.

Quantitative measurement of hard exudates in patients with diabetes and their associations with serum lipid levels.

Molecular mechanisms regulating ocular apoptosis in zebrafish gdf6a mutants.

Quantitative profiling of major neutral lipid classes in human meibum by direct infusion electrospray ionization mass spectrometry.

Inflammatory biomarkers and progression of diabetic retinopathy in African Americans with type 1 diabetes.

Biomechanical properties of human corneas following low- and high-intensity collagen cross-linking determined with scanning acoustic microscopy.

Quantitative assessment of the canine pupillary light reflex.

Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium.

Association study in a South Indian population supports rs1015213 as a risk factor for primary angle closure.

Theoretical Analysis of Vascular Regulatory Mechanisms Contributing to Retinal Blood Flow Autoregulation

Relationship between position of peak retinal nerve fiber layer thickness and retinal arteries on sectoral retinal nerve fiber layer thickness.

The retinal disease screening study: retrospective comparison of nonmydriatic fundus photography and three-dimensional optical coherence tomography for detection of retinal irregularities.

In vitro and in vivo comparison of two suprachoroidal shunts.

Measurement of tear film thickness using ultrahigh-resolution optical coherence tomography.

Onset and progression of peripapillary retinal nerve fiber layer (RNFL) retardance changes occur earlier than RNFL thickness changes in experimental glaucoma.

Symmetry of the pupillary light reflex and its relationship to retinal nerve fiber layer thickness and visual field defect.

In vivo morphology of the limbal palisades of vogt correlates with progressive stem cell deficiency in aniridia-related keratopathy.

Correlation between reflectivity of subretinal fluid in OCT images and concentration of intravitreal VEGF in eyes with diabetic macular edema.

Substratum compliance modulates corneal fibroblast to myofibroblast transformation.

Population-based assessment of prevalence and risk factors for pterygium in the South Indian state of Andhra Pradesh: the Andhra Pradesh Eye Disease Study.

Clinical and immunological characterization of paraneoplastic retinopathy.

Quantitative fundus autofluorescence in healthy eyes.

Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma.

Wide-field laser ophthalmoscopy for mice: a novel evaluation system for retinal/choroidal angiogenesis in mice.

Familial correlation of retinal vascular caliber in Singapore Chinese.

Handheld shape discrimination hyperacuity test on a mobile device for remote monitoring of visual function in maculopathy.

Effect of cataract surgery on optical coherence tomography measurements and repeatability in patients with non-insulin-dependent diabetes mellitus.

Selection of Phototransduction Genes in Homo sapiens.

IGFBP-3 and TNF- regulate retinal endothelial cell apoptosis.

Establishment of a human corneal epithelial cell line lacking the functional TACSTD2 gene as an in vitro model for gelatinous drop-like dystrophy.

Development of latanoprost-loaded biodegradable nanosheet as a new drug delivery system for glaucoma.

Entrance pupil size predicts retinal illumination in darkly pigmented eyes, but not lightly pigmented eyes.

Polychromatic angiography for the assessment of VEGF-induced BRB dysfunction in the rabbit retina.

Evaluation of contact lens-induced changes in keratoconic corneas using in vivo confocal microscopy.

Role of PKCα Activation of Src, PI-3K/AKT, and ERK in EGF-Stimulated Proliferation of Rat and Human Conjunctival Goblet Cells

The effects of tenascin C knockdown on trabecular meshwork outflow resistance.

Association of smoking and other risk factors with Fuchs' endothelial corneal dystrophy severity and corneal thickness.

Perimetric evaluation of saccadic latency, saccadic accuracy, and visual threshold for peripheral visual stimuli in young compared with older adults.

Anti-retinal antibodies in patients with macular telangiectasia type 2.

Novel molecular diagnostic system of limbal stem cell deficiency based on MUC5AC transcript detection in corneal epithelium by PCR-reverse dot blot.

Paraoxonase-1 is associated with corneal endothelial cell alterations in patients with chronic obstructive pulmonary disease.

Relationship between foveal cone structure and clinical measures of visual function in patients with inherited retinal degenerations.

Toll-like receptor 4 mediates retinal ischemia/reperfusion injury through nuclear factor-κB and spleen tyrosine kinase activation.

Clinical relevance of foveal location on retinal nerve fiber layer thickness using the new FoDi software in spectralis optical coherence tomography.

Changes in the photoreceptor mosaic of P23H-1 rats during retinal degeneration: implications for rod-cone dependent survival.

Soaring aspirations: lessons from my mentors and colleagues: the Weisenfeld award.

Introducing David Epstein, the 2013 recipient of the Weisenfeld award.

Lack of association between primary angle-closure glaucoma susceptibility loci and the ocular biometric parameters anterior chamber depth and axial length.

Ultrasound-Enhanced Penetration of Topical Riboflavin Into the Corneal Stroma

Alarmins from corneal epithelial cells upregulate CCL11 and VCAM-1 in corneal fibroblasts.

Effects of Y27632 on aqueous humor outflow facility with changes in hydrodynamic pattern and morphology in human eyes.

Major determinants of acute primary angle closure demonstrated by anterior segment optical coherence tomography.

Macrophages coming of age: their role in promoting CNV is modulated by FasL.

Dual tasking and balance in those with central and peripheral vision loss.

OCT predicts VEGF levels in human eyes.

AMD-associated variants at the chromosome 10q26 locus and the stability of ARMS2 transcripts.

Rethinking A2E.

Author response: Human corneal endothelium regeneration: effect of ROCK Inhibitor.

A forensic path to RGC-5 cell line identification: lessons learned.

Passing-Bablok regression is inappropriate for assessing association between structure and function in glaucoma.

Author response: Passing-Bablok regression is inappropriate for assessing association between structure and function.

Year: 2013 Volume: 54 Issue: 7

Year: 2013 Volume: 54 Issue: 6

Year: 2013 Volume: 54 Issue: 5

Year: 2013 Volume: 54 Issue: 4

Year: 2013 Volume: 54 Issue: 3

Year: 2013 Volume: 54 Issue: 2

Year: 2013 Volume: 54 Issue: 1

Year: 2012 Volume: 53

Year: 2011 Volume: 52

Year: 2010 Volume: 51

Year: 2009 Volume: 50

Year: 2008 Volume: 49

IGFBP-3 and TNF- regulate retinal endothelial cell apoptosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Soderland, Carl Jiang, Youde Liu, Li Miller, Matthew J. Steinle, Jena J. Kern, Timothy S. Pintar, John Zhang, Qiuhua Peng, Bonnie Tang, Jie
Description	Country affiliation: United States Author Affiliation: Zhang Q ( Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.)
Abstract	PURPOSE: We hypothesized that loss of insulin-like growth factor binding protein 3 (IGFBP-3) signaling would produce neuronal changes in the retina similar to early diabetes. METHODS: To understand better the role of IGFBP-3 in the retina, IGFBP-3 knockout (KO) mice were evaluated for neuronal, vascular, and functional changes compared to wild-type littermates. We also cultured retinal endothelial cells (REC) in normoglycemia or hyperglycemia to determine the interaction between IGFBP-3 and TNF- , as data indicate that both proteins are regulated by ß-adrenergic receptors and respond antagonistically. We also treated some cells with Compound 49b, a novel ß-adrenergic receptor agonist we have reported previously to regulate IGFBP-3 and TNF- . RESULTS: Electroretinogram analyses showed decreased B-wave and oscillatory potential amplitudes in the IGFBP-3 KO mice, corresponding to increased apoptosis. Retinal thickness and cell numbers in the ganglion cell layer were reduced in the IGFBP-3 KO mice. As expected, loss of IGFBP-3 was associated with increased TNF- levels. When TNF- and IGFBP-3 were applied to REC, they worked antagonistically, with IGFBP-3 inhibiting apoptosis and TNF- promoting apoptosis. Due to their antagonistic nature, results suggest that apoptosis of REC may depend upon which protein (IGFBP-3 versus TNF- ) is active. CONCLUSIONS: Taken together, loss of IGFBP-3 signaling results in a phenotype similar to neuronal changes observed in diabetic retinopathy in the early phases, including increased TNF- levels.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.13-12497
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-08-09
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Apoptosis Physiology Diabetes Mellitus, Experimental Diabetic Retinopathy Metabolism Endothelial Cells Insulin-like Growth Factor Binding Protein 3 Retina Tumor Necrosis Factor-alpha Animals Blotting, Western Cells, Cultured Pathology Physiopathology Electroretinography Mice Mice, Inbred C57bl Mice, Knockout Signal Transduction Comparative Study Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s. Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in