NDLI: Effects of Y27632 on aqueous humor outflow facility with changes in hydrodynamic pattern and morphology in human eyes.

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Effects of Y27632 on aqueous humor outflow facility with changes in hydrodynamic pattern and morphology in human eyes.

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Effects of Y27632 on aqueous humor outflow facility with changes in hydrodynamic pattern and morphology in human eyes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lu, Zhaozeng Ren, Ruiyi Liu, Ye Yang, Chen-Yuan Charlie Gong, Haiyan
Description	Country affiliation: United States Author Affiliation: Yang CY ( Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.)
Abstract	PURPOSE: To determine the effect of Y27632, a Rho-kinase inhibitor on aqueous outflow facility, flow pattern, and juxtacanalicular tissue (JCT)/trabecular meshwork (TM) morphology in human eyes. METHODS: Sixteen enucleated human eyes were perfused with PBS plus glucose (GPBS) at 15 mm Hg to establish the baseline outflow facility. Six eyes were perfused for short-duration (30 minute) with either 50 µM Y27632 or GPBS (n = 3 per group). Ten eyes were perfused for long duration (3 hours) with either 50 µM Y27632 or GPBS (n = 5 per group). Outflow pattern was labeled using fluorescent microspheres, and effective filtration length (EFL) was measured. Morphologic changes and their relationship to EFL and facility were analyzed. RESULTS: Outflow facility significantly increased after short-duration perfusion with Y27632 compared with its own baseline (P = 0.03), but did not reach statistical significance compared with its controls (P = 0.07). Outflow facility (P = 0.01) and EFL (P < 0.05) were significantly increased after long-duration perfusion with Y27632 compared with its controls. Increases in outflow facility and EFL demonstrated a positive correlation. Morphologically, the TM and JCT of high-tracer regions were more expanded compared with low-tracer regions. A significant increase in JCT thickness was found in the long-duration Y27632 group compared with its control group (10.0 vs. 8.0 µm, P < 0.01). CONCLUSIONS: Y27632 increases outflow facility in human eyes. This increase correlates positively with an increase in EFL, which is associated with an increased expansion in the JCT. Our data suggest that EFL could serve as a novel parameter to correlate with outflow facility.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.12-10930
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-08-28
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Amides Pharmacology Aqueous Humor Drug Effects Pyridines Rho-associated Kinases Antagonists & Inhibitors Secretion Immunohistochemistry Microscopy, Confocal Microscopy, Electron Regression Analysis Trabecular Meshwork Ultrastructure Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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