NDLI: Quantitative measurement of hard exudates in patients with diabetes and their associations with serum lipid levels.

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Quantitative measurement of hard exudates in patients with diabetes and their associations with serum lipid levels.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kawasaki, Ryo Lamoureux, Ecosse Noonan, Jonathan E. Sasaki, Mariko Wong, Tien Yin Wang, Jie Jin
Description	Country affiliation: Australia Author Affiliation: Sasaki M ( Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.)
Abstract	PURPOSE: To describe a reproducible method of quantifying macular hard exudates (HEs) in diabetic maculopathy and determine the associations of HEs with systemic risk factors. METHODS: Patients with diabetes were recruited from a tertiary eye hospital in Melbourne, Australia. Total macular area covered by HEs (total HE area) and the distance from the foveal center to the nearest HE were measured in a semi-automated manner. Associations between HE parameters and diabetic complication risk factors were examined using multiple linear regression models. RESULTS: Of 593 participants (mean age 60.5-years old), 97 (16.4%) had HEs in at least one eye, due to diabetic maculopathy. The intraclass correlation coefficients (ICC) for inter- and intra-observer agreements were 0.982 and 0.999, respectively. Total HE area was positively associated with qualitative HE severity scale determined by photographic graders. The median of total HE area was 0.089 mm(2) (interquartile range, 0.027-0.246). The median distance between foveal center and the nearest HE was 791.1 µm (431.9-1385.4). After adjusting for age, sex, duration of diabetes, glycated hemoglobin, mean arterial pressure, diabetic retinopathy level, and use of lipid-lowering medication, low density lipoprotein (LDL) cholesterol (P = 0.009), and triglyceride levels (P = 0.036) were positively associated with total HE area. Higher triglyceride levels were associated with central involvement (P = 0.023). CONCLUSIONS: Quantitative measurement of HEs in patients with diabetes is associated with lipid levels, and higher triglyceride levels are associated with a higher risk of central involvement. Quantitative information may be useful to monitor HE progression or treatment response in persons with diabetic maculopathy.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-08-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Diabetic Retinopathy Complications Diagnostic Imaging Exudates And Transudates Cytology Lipids Blood Macular Edema Diagnosis Metabolism Etiology Roc Curve Reproducibility Of Results Retrospective Studies Comparative Study Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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