NDLI: Effects of Tauroursodeoxycholic Acid and Alpha-Lipoic-Acid on the Visual Response Properties of Cat Retinal Ganglion Cells: An In Vitro Study.

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Effects of Tauroursodeoxycholic Acid and Alpha-Lipoic-Acid on the Visual Response Properties of Cat Retinal Ganglion Cells: An In Vitro Study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gao, Jie Huang, Xin Xia, Huika Pu, Mingliang Nan, Yan
Description	Author Affiliation: Xia H ( Department of Anatomy/Embryology School of Basic Medical Sciences, Peking University, Beijing, China 2Key Laboratory on Machine Perception (Ministry of Education), Peking University, Beijing, China 3Key Laboratory for Visual Impairment and Restoration (Mi.); Nan Y ( Department of Anatomy/Embryology School of Basic Medical Sciences, Peking University, Beijing, China 2Key Laboratory on Machine Perception (Ministry of Education), Peking University, Beijing, China 3Key Laboratory for Visual Impairment and Restoration (Mi.); Huang X ( Department of Anatomy/Embryology School of Basic Medical Sciences, Peking University, Beijing, China 2Key Laboratory on Machine Perception (Ministry of Education), Peking University, Beijing, China 3Key Laboratory for Visual Impairment and Restoration (Mi.); Gao J ( Department of Anatomy/Embryology School of Basic Medical Sciences, Peking University, Beijing, China 2Key Laboratory on Machine Perception (Ministry of Education), Peking University, Beijing, China 3Key Laboratory for Visual Impairment and Restoration (Mi.); Pu M ( Department of Anatomy/Embryology School of Basic Medical Sciences, Peking University, Beijing, China 2Key Laboratory on Machine Perception (Ministry of Education), Peking University, Beijing, China 3Key Laboratory for Visual Impairment and Restoration (Mi.)
Abstract	PURPOSE: To investigate the effects of tauroursodeoxycholic acid (TUDCA) and alpha-lipoic-acid (ALA) on the visual response properties of cat retinal ganglion cells (RGCs) in wholemount retinas. METHODS: Young adult cats were divided into three groups: control, ALA, and TUDCA. In vitro single-unit extracellular recordings were performed on wholemount retinas to objectively evaluate the visual response properties of RGCs prior and post to antioxidant treatment. The visual responses properties of RGCs, including receptive field size, luminance threshold, and contrast sensitivity, were collected online and analyzed off-line with Axon Pclamp9. RESULTS: Most of the RF sizes were larger than those plotted prior to the 60 minutes dark adaptation. The luminance threshold was elevated in the control group (no treatment) but reduced post ALA treatment and significantly reduced post TUDCA treatment. The contrast threshold was significantly elevated in the control group (no treatment) and clearly elevated post ALA treatment but effectively sustained post TUCDA treatment. CONCLUSIONS: Retinal neurocircuitry deteriorates in wholemount retinas, resulting in abnormal visual response properties in RGCs. Alpha-lipoic-acid and TUDCA exerted beneficial neuroprotective effects by activating the antioxidant pathway, partially restoring the functionality of retinal neurocircuitry and significantly improving the visual response properties of RGCs. However, TUDCA appears to be more effective than ALA in reducing irradiance thresholds and improving contrast sensitivity.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	11
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antioxidants Pharmacology Retinal Ganglion Cells Drug Effects Taurochenodeoxycholic Acid Thioctic Acid Animals In Vitro Techniques Microelectrodes Photic Stimulation Physiology Sensory Thresholds Vision, Ocular Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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