NDLI: Choroidal Thickness Evaluation Before and After Hemodialysis in Patients With and Without Diabetes.

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Choroidal Thickness Evaluation Before and After Hemodialysis in Patients With and Without Diabetes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Minami, Yoshiro Ishibazawa, Akihiro Yamashita, Takanori Yoshida, Akitoshi Nagaoka, Taiji Kitahara, Manabu
Description	Country affiliation: Japan Author Affiliation: Ishibazawa A ( Department of Ophthalmology Asahikawa Medical University, Asahikawa, Japan 2Department of Ophthalmology, Nayoro City General Hospital, Nayoro, Japan.); Nagaoka T ( Department of Ophthalmology Asahikawa Medical University, Asahikawa, Japan.); Minami Y ( Department of Ophthalmology, Nayoro City General Hospital, Nayoro, Japan.); Kitahara M ( Department of Urology, Nayoro City General Hospital, Nayoro, Japan.); Yamashita T ( Department of Urology, Nayoro City General Hospital, Nayoro, Japan.); Yoshida A ( Department of Ophthalmology Asahikawa Medical University, Asahikawa, Japan.)
Abstract	PURPOSE: We evaluated the effect of hemodialysis on the choroidal thickness in patients with and without diabetes who have end-stage kidney disease (ESKD). METHODS: Forty-one patients with ESKD were recruited and divided into two groups: those with ESKD due to diabetic nephropathy (DM group, 37 eyes of 20 patients) and those with nondiabetic ESKD (NDM group, 40 eyes of 21 patients). Using spectral-domain optical coherence tomography (SD-OCT), the subfoveal choroidal thickness (SCT) was measured before and after hemodialysis, and the change ratio (ΔSCT [%]) was calculated. RESULTS: The SCT decreased in all eyes after hemodialysis. The ΔSCT value in the DM group (-12.6 ± 2.7%) was significantly (P = 0.00027) larger than that in the NDM group (-6.9 ± 2.3%). Moreover, the ΔSCT per body fluid removal (BFR [L]) in the DM group was significantly (P = 0.013) greater than in the NDM group. In the DM group, the mean ΔSCT in the eyes treated with panretinal photocoagulation (PRP; n = 19) was significantly (P = 0.035) larger than that in eyes not treated with PRP (n = 18). The relationship between the ΔSCT and BFR was not significant (R² = 0.0038, P = 0.80) in the DM group but was significant (R² = 0.54, P = 0.00013) in the NDM group. CONCLUSIONS: The current results may reflect that systemic fluid accumulation has a greater effect on the diabetic choroid, probably due to damage to the choroidal vasculature, in patients with ESKD.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	11
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Choroid Diseases Diagnosis Choroid Pathology Diabetic Nephropathies Therapy Renal Dialysis Tomography, Optical Coherence Etiology Complications Fluorescein Angiography Fundus Oculi Kidney Failure, Chronic Retrospective Studies Visual Acuity Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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