NDLI: Ranibizumab and Aflibercept: Intraocular Pharmacokinetics and Their Effects on Aqueous VEGF Level in Vitrectomized and Nonvitrectomized Macaque Eyes.

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Ranibizumab and Aflibercept: Intraocular Pharmacokinetics and Their Effects on Aqueous VEGF Level in Vitrectomized and Nonvitrectomized Macaque Eyes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Niwa, Yuichi Kakinoki, Masashi Sawada, Tomoko Ohji, Masahito Wang, Xiying
Description	Country affiliation: Japan Author Affiliation: Niwa Y ( Department of Ophthalmology Shiga University of Medical Science, Otsu, Japan.); Kakinoki M ( Department of Ophthalmology Shiga University of Medical Science, Otsu, Japan.); Sawada T ( Department of Ophthalmology Shiga University of Medical Science, Otsu, Japan.); Wang X ( Department of Ophthalmology Shiga University of Medical Science, Otsu, Japan 2Key Laboratory of Harbin Medical University Eye Center, Eye Hospital, First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.); Ohji M ( Department of Ophthalmology Shiga University of Medical Science, Otsu, Japan.)
Abstract	PURPOSE: We evaluated the pharmacokinetics of intravitreally injected ranibizumab and aflibercept, and their effects on VEGF in the aqueous humor of vitrectomized and nonvitrectomized macaque eyes. METHODS: Intravitreal ranibizumab (IVR; 0.5 mg/50 µL) or intravitreal aflibercept (IVA; 2 mg/50 µL) was injected into the previously vitrectomized right eyes of three macaques and nonvitrectomized right eyes of three macaques. The left eyes served as controls (nonvitrectomized, noninjected). Aqueous humor was obtained from both eyes just before injection and on days 1 and 3, and weeks 1 to 8 after IVR and IVA. The ranibizumab, aflibercept, and VEGF concentrations were measured using enzyme-linked immunosorbent assays. RESULTS: The half-lives in aqueous humor of nonvitrectomized and vitrectomized eyes were, respectively, 2.3 and 1.4 days for ranibizumab, and 2.2 and 1.5 days for aflibercept. Concentration of VEGF was decreased below the limit of detection (LOD) by IVR for 3 weeks in nonvitrectomized eyes and 1 week in vitrectomized eyes, respectively, and by IVA for 6 weeks in nonvitrectomized eyes and 4 weeks in vitrectomized eyes, respectively. In the untreated control eyes, the ranibizumab and aflibercept concentrations were below the LOD, and the VEGF aqueous concentrations remained unchanged after IVR and decreased for 3 days after IVA. CONCLUSIONS: Intravitreally injected ranibizumab and aflibercept have similar half-lives in aqueous humor and shorter half-lives in vitrectomized eyes. Compared to IVR, IVA suppresses VEGF level for a longer time period.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	11
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aqueous Humor Metabolism Macular Degeneration Drug Therapy Ranibizumab Pharmacokinetics Receptors, Vascular Endothelial Growth Factor Recombinant Fusion Proteins Vascular Endothelial Growth Factor A Vitrectomy Vitreous Body Angiogenesis Inhibitors Administration & Dosage Animals Drug Effects Disease Models, Animal Enzyme-linked Immunosorbent Assay Intravitreal Injections Macaca Pathology Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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