| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Boatright, Jeffrey H. Prunty, Megan Aung, Moe H. Gogniat, Marissa Hanif, Adam M. Chakraborty, Ranjay Pardue, Machelle T. Lawson, Eric C. |
| Description |
Country affiliation: United States Author Affiliation: Hanif AM ( Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, Georgia, United States.); Lawson EC ( Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, Georgia, United States.); Prunty M ( Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, Georgia, United States.); Gogniat M ( Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, Georgia, United States.); Aung MH ( Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, United States.); Chakraborty R ( Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, United States.); Boatright JH ( Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, Georgia, United States 2Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, United States.); Pardue MT ( Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, Georgia, United States 2Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, United States.) |
| Abstract |
PURPOSE: Our previous investigations showed that involuntary treadmill exercise is neuroprotective in a light-induced retinal degeneration mouse model, and it may act through activation of tropomyosin-related kinase B (TrkB) receptors. This study investigated whether voluntary running wheel exercise can be neuroprotective in an inheritable model of the retinal degenerative disease retinitis pigmentosa (RP), rd10 mice. METHODS: Breeding pairs of rd10 and C57BL/6J mice were given free-spinning (active) or locked (inactive) running wheels. Pups were weaned into separate cages with their parents' respective wheel types, and visual function was tested with ERG and a virtual optokinetic system at 4, 5, and 6 weeks of age. Offspring were killed at 6 weeks of age and retinal cross-sections were prepared for photoreceptor nuclei counting. Additionally, separate cohorts of active and inactive rd10 pups were injected daily for 14 days after eye opening with a selective TrkB receptor antagonist (ANA-12) or vehicle solution and assessed as described above. RESULTS: Mice in the rd10 active group exhibited significant preservation of visual acuity, cone nuclei, and total photoreceptor nuclei number. Injection with ANA-12 precluded the preservation of visual acuity and photoreceptor nuclei number in rd10 mice. CONCLUSIONS: Voluntary running partially protected against the retinal degeneration and vision loss that otherwise occurs in the rd10 mouse model of RP. This protection was prevented by injection of ANA-12, suggesting that TrkB activation mediates exercise's preservation of the retina. Exercise may serve as an effective, clinically translational intervention against retinal degeneration. |
| ISSN |
01460404 |
| e-ISSN |
15525783 |
| DOI |
10.1167/iovs.15-16792 |
| Journal |
Investigative Opthalmology & Visual Science |
| Issue Number |
11 |
| Volume Number |
56 |
| Language |
English |
| Publisher |
Association for Research in Vision and Ophthalmology |
| Publisher Date |
2015-10-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Neuroprotection Physiology Physical Conditioning, Animal Receptor, Trkb Retinitis Pigmentosa Physiopathology Analysis Of Variance Animals Azepines Pharmacology Benzamides Disease Models, Animal Electroretinography Mice Mice, Inbred C57bl Drug Effects Antagonists & Inhibitors Retinal Cone Photoreceptor Cells Cytology Retinal Rod Photoreceptor Cells Prevention & Control Visual Acuity Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s. Discipline Ophthalmology |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Ophthalmology Sensory Systems Cellular and Molecular Neuroscience |
