NDLI: Therapeutic Effect of Resveratrol on Oxidative Stress in Graves' Orbitopathy Orbital Fibroblasts.

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Therapeutic Effect of Resveratrol on Oxidative Stress in Graves' Orbitopathy Orbital Fibroblasts.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Byun, Jung Woo Lee, Eun Jig Yoon, Jin Sook Lee, Hyun Jung Kim, Chang Yeom Chae, Min Kyung
Description	Author Affiliation: Kim CY ( Institute of Vision Research Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.); Lee HJ ( Department of Ophthalmology, Catholic University College of Medicine, Seoul, Korea.); Chae MK ( Institute of Vision Research Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.); Byun JW ( Institute of Endocrine research, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.); Lee EJ ( Institute of Endocrine research, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.); Yoon JS ( Institute of Vision Research Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.)
Abstract	PURPOSE: Multiple causative factors complicate the pathogenesis in Graves' orbitopathy (GO). It has been suggested that oxidative stress contributes to the development and progression of GO. Therefore, we investigated the therapeutic effect of resveratrol, a potent antioxidant, upon oxidative stress levels in GO orbital fibroblasts in vitro. METHODS: Orbital fibroblasts were cultured from orbital connective tissues obtained from GO patients. Intracellular reactive oxygen species (ROS) levels and the expression of heme oxygenase-1 (HO-1), superoxide dismutase (SOD), catalase, and thioredoxin (Trx), were measured after resveratrol treatment. Adipogenesis was induced, and ROS levels were examined during adipogenic differentiation. Western blot assay was performed to evaluate the effects of resveratrol on the expression of antioxidants levels and transcriptional regulators. RESULTS: Treatment with 30 or 50 µM resveratrol reduced ROS production and HO-1 level induced by oxidative stress. Levels of Cu/Zn-SOD, catalase, and Trx were also reduced, while Mn-SOD increased with 50 µM resveratrol treatment. Resveratrol suppressed adipogenesis, reducing the number of adipocytes and suppressing the accumulation of lipid droplets. Treatment with 50 µM resveratrol also decreased ROS levels during adipogenesis. Expression of the transcriptional regulators phosphor-extracellular signal-regulated kinase and phospho-c-Jun NH(2)-terminal kinase significantly increased after treatment with 50 µM resveratrol, and decreased in response to inhibitors of each protein. Phosphonuclear factor kappa-light-chain-enhancer of activated B cells p65 levels also increased after treatment with 50 µM resveratrol. CONCLUSIONS: Resveratrol reduced ROS levels and inhibited adipogenesis in GO orbital fibroblasts in vitro. This study supports the potential use of resveratrol in GO treatment.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	11
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adipocytes Pathology Adipogenesis Drug Effects Graves Ophthalmopathy Drug Therapy Oxidative Stress Stilbenes Therapeutic Use Metabolism Angiogenesis Inhibitors Antioxidants Cell Proliferation Cells, Cultured Fibroblasts Reactive Oxygen Species Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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