NDLI: Correlation Between Hyperreflective Foci and Clinical Outcomes in Neovascular Age-Related Macular Degeneration After Switching to Aflibercept.

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Correlation Between Hyperreflective Foci and Clinical Outcomes in Neovascular Age-Related Macular Degeneration After Switching to Aflibercept.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Framme, Carsten Junker, Bernd Pielen, Amelie Abri Aghdam, Kaveh
Description	Country affiliation: Iran Author Affiliation: Abri Aghdam K ( University Eye Hospital Hannover Medical School, Hannover, Germany 2Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.); Pielen A ( University Eye Hospital Hannover Medical School, Hannover, Germany.); Framme C ( University Eye Hospital Hannover Medical School, Hannover, Germany.); Junker B ( University Eye Hospital Hannover Medical School, Hannover, Germany.)
Abstract	PURPOSE: To assess the correlation between hyperreflective foci (HF) and visual and anatomical outcomes in treatment-resistant neovascular age-related macular degeneration (AMD) using spectral-domain optical coherence tomography (SD-OCT). METHODS: This was a prospective interventional case series. Thirty-three eyes of 30 consecutive patients with treatment-resistant neovascular AMD were enrolled. Intravitreal aflibercept injections were performed at week 0 (baseline), week 4, and week 8. Spectral-domain OCT images were obtained before each injection and 4 weeks after the third injection. The main focus was on the measurement of choroidal neovascularization (CNV) size in the cross-sectional area in the B-scan through the fovea, and HF number along line segments of 1- and 3-mm length passing through the fovea. RESULTS: Mean number of HF in the radius of 500 µm decreased from 8.36 ± 7.58 to 4.15 ± 3.39 (P = 0.02). Mean number of HF in the radius of 1500 µm was reduced from 21.30 ± 12.47 to 10.45 ± 6.34 (P < 0.001). Mean CNV area decreased from 0.35 ± 0.22 to 0.22 ± 0.16 mm2 (P < 0.001). There was a significant positive correlation between HF reduction in the radius of 500 µm and decrease in central subfield thickness (CST) (r = 0.43, P = 0.01), but no statistically significant correlation was found between HF decline in the radius of 1500 µm and other parameters. CONCLUSIONS: Switching from ranibizumab to aflibercept caused significant decrease in the number of HF 1 month after aflibercept upload, and HF decrease in the radius of 500 µm was correlated positively with the reduction in CST.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	11
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Choroidal Neovascularization Drug Therapy Macular Degeneration Receptors, Vascular Endothelial Growth Factor Administration & Dosage Recombinant Fusion Proteins Angiogenesis Inhibitors Pathology Fluorescein Angiography Fundus Oculi Intravitreal Injections Complications Prospective Studies Ranibizumab Tomography, Optical Coherence Visual Acuity Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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