| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Abudunaibi, M. Mulati, A. Aili, A. Zulifeiya, M. Aisikaer, S. Qiao, J. Gulibositan, M. Halmurat, U. |
| Description |
Country affiliation: China Author Affiliation: Abudunaibi M ( Department of Cardiac Surgery, First Teaching Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.); Mulati A ( Department of Cardiac Surgery, First Teaching Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China nebi-boss@hotmail.com.); Aisikaer S ( Department of Cardiac Surgery, First Teaching Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.); Zulifeiya M ( Department of Cardiac Surgery, First Teaching Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.); Qiao J ( Department of Cardiac Surgery, First Teaching Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.); Gulibositan M ( Otolaryngology Department of Xinjiang Autonomous Region People's Hospital, Xinjiang, China.); Aili A ( Department of Cardiac Surgery, First Teaching Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.); Halmurat U ( Uyghur Medicine Institute of Xinjiang Medical University, Xingiang, China.) |
| Abstract |
This study evaluated the influence and mechanism of different Munziq doses on myocardial ischemia reperfusion injury (MIRI) rats with abnormal savda. Wistar rats (N = 96) were divided into the following 8 groups (12 rats each): ischemia-reperfusion (I/R) model group, high-dose, medium-dose, and low-dose Munziq groups, normal I/R group, sham model group, normal sham group, and Atorvastatin group. Changes in heart physiology and myocardial morphology after injury with MIRI were monitored in each group. Heat shock protein 70 (HSP70) and calcitonin gene-related peptide (CGRP) protein expression and serum concentrations of superoxide dismutase (SOD), malondialdehyde (MDA), interleukin (IL)-6, and IL-8 were detected by using western blot and ELISA methods, respectively. The large-dose Munziq group showed the most significant changes. The VPC incurring time was not delayed in the small-dose group, but the accumulative time was significantly reduced (P < 0.01). The ventricular tachycardia incurring time did not differ significantly between groups. Compared with the normal sham surgical group, the I/R groups showed significant increases in HSP70 and CGRP expression (P < 0.01) and MDA, IL-6, and IL-8 concentrations (P < 0.05) and a significant decrease in the SOD concentration (P < 0.05). Compared with the I/R groups, Munziq intervention significantly enhanced HSP70 and CGRP expression (P < 0.01), significantly decreased MDA, IL-6, and IL-8 concentrations (P < 0.05), and significantly increased the SOD concentration (P < 0.05). In conclusion, Munziq intervention improves cardiac physiological function, increases the expression of HSP70 and CGRP, and decreases the inflammatory reaction in MIRI model rats. |
| e-ISSN |
16765680 |
| Journal |
Genetics and Molecular Research |
| Issue Number |
2 |
| Volume Number |
14 |
| Language |
English |
| Publisher |
Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date |
2015-04-15 |
| Publisher Place |
Brazil |
| Access Restriction |
Open |
| Subject Keyword |
Cardiotonic Agents Pharmacology Myocardial Reperfusion Injury Prevention & Control Plant Extracts Animals Arterial Pressure Atorvastatin Calcium Therapeutic Use Drug Evaluation, Preclinical Hsp70 Heat-shock Proteins Metabolism Interleukin-6 Blood Interleukin-8 Malondialdehyde Physiopathology Rats, Wistar Superoxide Dismutase Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type |
Text |
| Resource Type |
Article |
