NDLI: Potential hippocampal genes and pathways involved in Alzheimer's disease: a bioinformatic analysis.

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Year: 2016 Volume: 15

Year: 2016 Volume: 14

Year: 2015 Volume: 14

Year: 2015 Volume: 14 Issue: 4

Year: 2015 Volume: 14 Issue: 3

Year: 2015 Volume: 14 Issue: 2

Role of APN and TNF- in type 2 diabetes mellitus complicated by nonalcoholic fatty liver disease.

A multiplex panel of short-amplicon insertion-deletion DNA polymorphisms for forensic analysis.

Case Report: Local skin flap with vacuum-seal drainage to facilitate healing of ACS.

Effects of musk ketone on nerve recovery after spinal cord injury.

In vitro differentiation of sperm from male germline stem cell.

Effects of modified Shoutaiwai recipe on integrin ß3 and leukemia-inhibitory factor in endometrium of controlled ovarian hyperstimulation mice during the implantation window.

Association between PARK16 gene polymorphisms and susceptibility of Parkinson's disease in a Chinese population.

Effects of bisphenol A on decreasing the percentage and promoting the growth of stem cell-like cells from SK-N-SH human neuroblastoma cells.

Postpartum pelvic floor function performance after two different modes of delivery.

Relationship between serum GAD-Ab and the genetic polymorphisms of GAD2 and type 2 diabetes mellitus.

Clinical observation of umbilical cord mesenchymal stem cell treatment of severe systolic heart failure.

Protective effect of ischemia preconditioning on ischemia-reperfusion injury in rat liver transplantation.

Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.

Cloning and expression analysis of a heat shock protein 90 ß isoform gene from the gills of Wuchang bream (Megalobrama amblycephala Yih) subjected to nitrite stress.

Optimization of SCoT-PCR reaction system in Dactylis glomerata by orthogonal design.

Promotive effect of comprehensive management on achieving blood glucose control in senile type 2 diabetics.

Variation and genetic structure of Tunisian Festuca arundinacea populations based on inter-simple sequence repeat pattern.

Erlotinib enhances the CIK cell-killing sensitivity of lung adenocarcinoma A549 cells.

Molecular cloning and tissue distribution profiles of the chicken R-spondin1 gene.

Antibody study in canine distemper virus nucleocapsid protein gene-immunized mice.

Characterization of the male-specific lethal 3 gene in the oriental river prawn, Macrobrachium nipponense.

Association between the CYP11B2 gene -344T>C polymorphism and coronary artery disease: a meta-analysis.

Brief Note :Variability in the cathelicidin 6 (CATHL-6) gene in Tianzhu white yak from Tibetan area in China.

Effect of hydroxy safflower yellow A on myocardial apoptosis after acute myocardial infarction in rats.

Association between genetic polymorphisms of PTGS2 and glioma in a Chinese population.

Involvement of AP-1 in p38MAPK signaling pathway in osteoblast apoptosis induced by high glucose.

Ammonia concentration and relative humidity in poultry houses affect the immune response of broilers.

Distinct non-cerebrovascular risk factors for ischemic lacunar stroke and non-lacunar stroke: preliminary results.

Role of interleukin-6 gene polymorphisms in the risk of coronary artery disease.

Effects of AFP gene silencing on Survivin mRNA expression inhibition in HepG2 cells.

Benefits of minimizing immunosuppressive dosage according to cytochrome P450 3A5 genotype in liver transplant patients: findings from a single-center study.

Evaluation of a modified sampling method for molecular analysis of air microflora.

Genome-wide polymorphisms between the parents of an elite hybrid rice and the development of a novel set of PCR-based InDel markers.

Study of optimal scheme of spinal image-guided radiotherapy based on expression of caspase-3 in spinal cord neurons by orthogonal design.

Complete mitochondrial genome of the Cyclemys dentata and phylogenetic analysis of the major family Geoemydidae.

Correlation between sheep YAP1 temporal and spatial expression trends and MSTN and MyoG gene expression.

IL-10 and IL-12B gene polymorphisms in a multiethnic Malaysian population.

Immune protective mechanism of rMOMP protein ophthalmic vaccine regarding intraocular hypertension and retinal optic nerve injury in rats.

Differential gene expression of epigenetic modifying enzymes between Tibet pig and Yorkshire in high and low altitudes.

Hypoxia-inducible factor-2 (HIF-2 ) mediates the effects of hypoxia on the promotion of HeLa cell viability, colony formation, and invasion capacity in vitro.

Compound heterozygosity of a novel exon 3 frameshift (p.R357P fs*24) mutation and Y486D mutation in exon 5 of the UGT1A1 gene in a Thai infant with Crigler-Najjar syndrome type 2.

Cloning and expression analysis of terpenoid metabolism-related gene NsyCMS in Nicotiana sylvestris.

Expression and significance of SATB1 in the development of breast cancer.

Novel genetic male sterility developed in (Capsicum annuum x C. chinense) x C. pubescens and induced by HNO2 showing Mendelian inheritance and aborted at telophase of microspore mother cell stage.

Expression of ß-defensins in intestines of chickens injected with vitamin D3 and lipopolysaccharide.

Case Report Serious pulmonary infection in a splenectomized patient with adult type 1 Gaucher disease.

Conventional and contrast-enhanced ultrasound assessment of craniocerebral gunshot wounds.

Isolation and characterization of cancer stem cells from medulloblastoma.

Changes to the migratory inhibitory factor, IL-17, and IL-10 levels in serum from chronic hepatitis B patients and clinical significance following Baraclude(®) treatment.

IGFBP-3 A-202C and C2133G polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies.

Insights about the genetic diversity and population structure of an offshore group of common bottlenose dolphins (Tursiops truncatus) in the Mid-Atlantic.

Mutation analysis of PVRL1 in patients with non-syndromic cleft of the lip and/or palate in Guangdong.

Gene expression profiling analysis of 5-hydroxytryptamine signaling pathway in rat regenerating liver and different types of liver cells.

Immunomodulatory and clinical effects of the 'tiaomian III decoction' in patients with blood blocking antibody deficiency and recurrent spontaneous abortion.

Myocardial protective effects of Munziq in myocardial ischemia-reperfusion injury rats with abnormal savda syndrome.

Construction of recombinant human IFN -2b BCG and its antitumor effects on bladder cancer cells in vitro.

Effect of curcumin on p38MAPK expression in DSS-induced murine ulcerative colitis.

Comparative study of clinical efficacy of laparoscopy-assisted radical gastrectomy versus open radical gastrectomy for advanced gastric cancer.

Highly efficient one-step PCR-based mutagenesis technique for large plasmids using high-fidelity DNA polymerase.

Relationship between EPHX2 gene polymorphisms and essential hypertension in Uygur, Kazakh, and Han.

Relative quantification of beta-casein expression in primary goat mammary epithelial cell lines.

Association between methionine synthase reductase A66G polymorphism and primary infertility in Chinese males.

Study of the significance of iron deficiency indexes and erythrocyte parameters in anemic pregnant women and their newborns.

Fragmentation effects and genetic diversity of the key semidecidual forest species Metrodorea nigra in Southwestern Brazil.

Correlation of MSH3 polymorphisms with response and survival in advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy.

Dual role of vitamin D-binding protein 1F allele in chronic obstructive pulmonary disease susceptibility: a meta-analysis.

Isolation and characterization of novel polymorphic microsatellite loci in Atrina vexillum Born (Pinnidae).

Role of TGFB1 polymorphism in the development of metastatic brain tumors in non-small cell lung cancer patients.

Neuroprotective effect of ketamine on acute spinal cord injury in rats.

Genetic analysis of QTL for eye cross and eye diameter in common carp (Cyprinus carpio L.) using microsatellites and SNPs.

Health and production traits in bovine are associated with single nucleotide polymorphisms in the NOD2 gene.

Population genetic structure and historical demography of the ground beetle Chlaenius costiger in the Tsinling-Dabashan Mountains of central China.

Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk.

Short Communication: Diversity of TNF- region in Chinese domestic goats.

Therapeutic influence of intraperitoneal injection of Wharton's jelly-derived mesenchymal stem cells on oviduct function and fertility in rats with acute and chronic salpingitis.

Case Report: Whole-exome analysis of a child with polycystic kidney disease and ventriculomegaly.

Cloning and analysis of the soybean MEKK gene.

Clinical value of concurrent radiochemotherapy in cervical cancer and comparison of ultrasonography findings before and after radiochemotherapy.

DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis.

Effects of silver nanoparticles and gold nanoparticles on IL-2, IL-6, and TNF- production via MAPK pathway in leukemic cell lines.

Novel polymorphisms of the PRKAG2 gene and their association with body measurement and meat quality traits in Qinchuan cattle.

Evaluation of the function status of the ulnar nerve in carpal tunnel syndrome.

Rapid sedation induced by fentanyl combined with propofol via an intrathecal chemotherapy injection for leukemia in children.

Feasibility of comfortable and secure intubation achieved with the Disposcope endoscope or Macintosh laryngoscope for patients in whom glottis viewing is difficult.

A comparative study of stress-related gene expression under single stress and intercross stress in rice.

Attenuated mRNA expression of lipid metabolism genes in primary hepatocytes following lipopolysaccharide treatment in dairy cows.

Expression and variation of Myf5 and MyoD1 genes in different tissues of Wuzhishan pigs.

Adeno-associated virus-mediated BMP-7 and SOX9 in vitro co-transfection of human degenerative intervertebral disc cells.

Relationship between genetic polymorphisms in MCP-1, CCR-2, and non-small-cell lung cancer in the Han nationality of Northern China.

Investigating the prevention of hospital-acquired infection through standardized teaching ward rounds in clinical nursing.

Transthoracic closure of atrial septal defect and ventricular septal defect without cardiopulmonary bypass.

T174M polymorphism in the angiotensinogen gene and risk of myocardial infarction: a meta-analysis.

Decreased levels of soluble receptor for advanced glycation end-products in aortic valve calcification patients.

Clinical value of ultrasound-guided percutaneous biopsy of pulmonary lesions.

Analysis of tacrolimus blood concentrations in renal transplant patients.

Preoperative computed tomography-guided hook-wire positioning of pulmonary nodules.

Analysis of ROP signaling in the leaf epidermis of mutant tomato with low-energy ion beam.

tRNALeu intron (UAA) of Ficus carica L.: genetic diversity and evolutionary patterns.

Clinical observational study of conformal radiotherapy combined with topotecan chemotherapy in patients with platinum-resistant recurrent ovarian cancer.

Polymorphisms in the SIRT5 gene and their association with body measurement and ultrasound traits in Qinchuan cattle.

QTL mapping of forage yield and forage yield component traits in Sorghum bicolor x S. sudanense.

Effect of different time phases of radionuclide hepatobiliary scintigraphy on the differential diagnosis of congenital biliary atresia.

Association between MTHFR 677C/T polymorphism and psoriasis risk: a meta-analysis.

Serum immunoglobulin E level and its impact on the pregnancy outcome associated with fetal growth restriction: a prospective cohort study.

Immunohistochemical subtypes of diffuse large B-cell lymphoma in the head and neck region.

Effects of p-chlorophenoxyisobutyric acid, arabinogalactan, and activated charcoal on microspore embryogenesis in kale.

Selected representative microsatellite loci for genetic monitoring and population structure analysis of miniature swine.

CYFRA21-1 levels could be a biomarker for bladder cancer: a meta-analysis.

Co-culture of annulus fibrosus cells and bone marrow mesenchymal stem cells.

High-resolution color doppler ultrasound examination and related risk factor analysis of lower extremity vasculopathy in type 2 diabetes patients.

Expression profiles of retinoic acid synthetases ALDH1As and metabolic enzymes CYP26s in adult and embryonic zebrafish (Danio rerio).

Rapid discrimination between four seagrass species using hybrid analysis.

Cytoplasmic polymorphism and evolutionary history of plum cultivars: Insights from chloroplast DNA sequence variation of trnL-trnF spacer and aggregated trnL intron & trnL-trnF spacer.

Development of novel microsatellite markers for conservation genetic studies of Vulpes vulpes (Canidae) by using next-generation sequencing method.

Effect of Fimbristylis ovata on receptor for advanced glycation end-products, proinflammatory cytokines, and cell adhesion molecule level and gene expression in U937 and bEnd.3 cell lines.

Identification of differentially expressed genes in a pistillody common wheat mutant using an annealing control primer system.

Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299.

Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with breast cancer in a Mexican population.

Analysis and clinical significance of microRNA-499 expression levels in serum of patients with acute myocardial infarction.

MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis.

Single-nucleotide polymorphisms in dopamine receptor D1 are associated with heroin dependence but not impulsive behavior.

Cytogenetic description of Ancistrus abilhoai (Siluriformes: Loricariidae) from Iguaçu River basin, southern Brazil.

Overexpression of pucC improves the heterologous protein expression level in a Rhodobacter sphaeroides expression system.

A new repertoire of informations about the quorum sensing system in Salmonella enterica serovar Enteritidis PT4.

3'-UTR polymorphism (rs10434) in the VEGF gene is associated with B-CLL in a Chinese population.

Single nucleotide polymorphism analysis of the endopolygalacturonase gene in peach and its potential use in crossbreeding programs.

Effects of autologous SCF- and G-CSF-mobilized bone marrow stem cells on hypoxia-inducible factor-1 in rats with ischemia-reperfusion renal injury.

Mating system patterns of natural populations of Pinus koraiensis along its post-glacial colonization route in northeastern China.

A novel FBN1 heterozygous mutation identified in a Chinese family with autosomal dominant Marfan syndrome.

Meta-analysis of microsomal epoxide hydrolase gene polymorphism and the risk of breast carcinoma.

Association between polymorphisms in the adiponectin gene (APM-1) and atherosclerotic cerebral infarction in a Hainan Chinese Han population.

MicroRNA-21 promotes proliferation of rat hepatocyte BRL-3A by targeting FASLG.

Association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with ischemic stroke in the Eastern Chinese Han population.

Plasma exchange parameter selection and safety observation of children with severe ricinism.

Genetic diversity and differentiation in Prunus species (Rosaceae) using chloroplast and mitochondrial DNA CAPS markers.

Muscle pain, fever, cough, and progressive dyspnea in a woman with eosinophilic pneumonia.

Chromosome stickiness impairs meiosis and influences reproductive success in Panicum maximum (Poaceae) hybrid plants.

Acute toxic effects of sonodynamic therapy on hypertrophic scar fibroblasts of rabbit ears.

Structural modeling and analysis of dengue-mediated inhibition of interferon signaling pathway.

An efficient algorithm for computing fixed length attractors based on bounded model checking in synchronous Boolean networks with biochemical applications.

Mitochondrial DNA diversity of feral pigs from Karukinka Natural Park, Tierra del Fuego Island, Chile.

Influence of cyclophilin D protein expression level on endothelial cell oxidative damage resistance.

Study of the relationship between the expression of nerve growth factor and aneurysm formation and prognosis.

Relationship between abnormal NOS expression and the pathogenesis of cerebral aneurysm.

Correlation between p53 and epidermal growth factor receptor expression in breast cancer classification.

Ultrasonic imaging of gunshot wounds in pig limb.

Distribution of forensic marker allelic frequencies in Pernambuco, Northestern Brazil.

Association of CD14 C159T polymorphism with atopic asthma susceptibility in children from Southeastern China: a case-control study.

Molecular cloning and expression analysis of female sterile homeotic gene (fsh) in the oriental river prawn Macrobrachium nipponense.

Deciphering the spectrum of somatic mutations in the entire mitochondrial DNA genome.

Relation between prognosis and changes of MBP and S100B in premature infants with periventricular leukomalacia.

Effect of ulinastatin on HMGB1 expression in rats with acute lung injury induced by sepsis.

Effect of polymorphisms of vascular endothelial growth factor on prognosis in osteosarcoma patients.

Malondialdehyde and SOD-induced changes of gastric tissues in acute gastric mucosal injury under positive acceleration.

Screening of molecular markers linked to dwarf trait in crape myrtle by bulked segregant analysis.

Establishment of a prediction model for the miRNA-based heading date characteristics of rice in the booting stage.

Expression and clinical significance of ADAM17 protein in esophageal squamous cell carcinoma.

Body color development and genetic analysis of hybrid transparent crucian carp (Carassius auratus).

Molecular cloning and expression analysis of TRAF3 in chicken.

Characterization and expression of DDX6 during gametogenesis in the Chinese mitten crab Eriocheir sinensis.

Analysis of genetic diversity of salt-tolerant alfalfa germplasms.

Characterization of MUSTN1 gene and its relationship with skeletal muscle development at postnatal stages in Pekin ducks.

TGF-ß1 polymorphism 509 C>T is associated with an increased risk for hepatocellular carcinoma in HCV-infected patients.

Association of genetic polymorphisms in TERT-CLPTM1L with lung cancer in a Chinese population.

Association of interleukin-1ß -511C/T promoter polymorphism with COPD risk: a meta-analysis.

Expression of EpCAM and Wnt/ ß-catenin in human colon cancer.

ß-asarone from Acorus gramineus alleviates depression by modulating MKP-1.

A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese.

A novel mutation links to von Hippel-Lindau syndrome in a Chinese family with hemangioblastoma.

Expression of high-mobility group box protein 1 in diabetic foot atherogenesis.

Cumulative methylation alternations of gene promoters and protein markers for diagnosis of epithelial ovarian cancer.

Clinicopathological analysis of idiopathic membranous nephropathy in young adults.

Taxonomic status of Pinus henryi using multiplexed microsatellite markers.

Novel bioinformatic identification of differentially expressed tissue-specific and cancer-related proteins from the Human Protein Atlas for biomarker discovery.

Phylogeographic analysis of African swine fever virus based on the p72 gene sequence.

Molecular cloning and expression analysis of GhLOF genes in upland cotton (Gossypium hirsutum L.).

Association between the rs189037 single nucleotide polymorphism in the ATM gene promoter and cognitive impairment.

Zhi-Long-Huo-Xue-Tong-Yu modulates mitochondrial fission through the ROCK1 pathway in mitochondrial dysfunction caused by streptozotocin-induced diabetic kidney injury.

Correlation between polymorphism of platelet alloantigen genes HPA-1-5 and type 2 diabetes complication by carotid atherosclerosis in a Chinese population.

Matrix metalloproteinase variants associated with risk and clinical outcome of esophageal cancer.

Effects of hydroxycamptothecin on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1, and type I collagen in rats with pulmonary fibrosis.

Development and characterization of microsatellite loci in Megalonibea fusca.

Application of molecular markers to detect DNA damage caused by environmental pollutants in lichen species.

Efficacy of combined hepatitis B immunoglobulin and hepatitis B vaccine in blocking father-infant transmission of hepatitis B viral infection.

Detection of Toxoplasma gondii DNA in Brazilian oysters (Crassostrea rhizophorae).

Molecular cloning and expression analysis of MyD88 in spiny head croaker, Collichthys lucidus.

A rapid and sensitive loop-mediated isothermal amplification procedure (LAMP) for Mycoplasma hyopneumoniae detection based on the p36 gene.

Selection of putative Terra Maranhão plantain cultivar mutants obtained by gamma radiation.

Isolation and characterization of microsatellite markers for Axonopus compressus (Sw.) Beauv. (Poaceae) using 454 sequencing technology.

Expression of genes associated with the biosynthetic pathways of abscisic acid, gibberellin, and ethylene during the germination of lettuce seeds.

Values for serum procalcitonin, C-reactive protein, and soluble triggering receptor expressed on myeloid cells-1 in predicting survival of patients with early-onset stroke-associated pneumonia.

Identification of differentially expressed genes associated with flower color in peach using genome-wide transcriptional analysis.

Effects of propofol and etomidate pretreatment on glucocorticoid receptor expression following induction of sepsis in rats.

Characterization of abnormal epithelium after laser-assisted subepithelial keratectomy using in vivo confocal microscopy.

Identification of novel compound heterozygous RECQL4 mutations and prenatal diagnosis of Baller-Gerold syndrome: a case report.

Functional polymorphisms in microRNA gene and hepatitis B risk among Asian population: a meta-analysis.

Effects of analgesia methods on serum IL-6 and IL-10 levels after cesarean delivery.

Transcriptome analysis of Arabidopsis seedlings responses to high concentrations of glucose.

Bioinformatic analysis of the effect of type II diabetes on skin wound healing.

Next-generation sequencing identification and characterization of microsatellite markers in Aconitum austrokoreense Koidz., an endemic and endangered medicinal plant of Korea.

Identification of highly expressed host microRNAs that respond to white spot syndrome virus infection in the Pacific white shrimp Litopenaeus vannamei (Penaeidae).

Genetic divergence for high-molecular weight glutenin subunits (HMW-GS) in indigenous landraces and commercial cultivars of bread wheat of Pakistan.

Relationship between carotid artery atherosclerosis and sulfatide in hypertensive patients.

Role of a liver fatty acid-binding protein gene in lipid metabolism in chicken hepatocytes.

Computed tomography-guided percutaneous microwave ablation therapy for lung cancer.

Genetic diversity and historical demography of the narrow-range endemic Alpine toad, Scutiger liupanensis, in the Liupan Mountains of central China.

Ascorbate peroxidase from Jatropha curcas enhances salt tolerance in transgenic Arabidopsis.

Polymorphisms of the Osteocrin gene and its association with meat quality traits in Qinchuan cattle.

Comparison of integrated traditional Chinese and western medicine therapy on vascular cognitive impairment with no dementia.

Identification and expression analysis of the MSP130-related-2 gene from Hyriopsis cumingii.

Clinical analysis of penehyclidine hydrochloride combined with hemoperfusion in the treatment of acute severe organophosphorus pesticide poisoning.

Molecular characterization of the endophytic fungal community associated with Eichhornia azurea (Kunth) and Eichhornia crassipes (Mart.) (Pontederiaceae) native to the Upper Paraná River floodplain, Brazil.

Changes in peripheral blood natural killer T cells in hepatitis B e antigen-positive chronic hepatitis B patients and efficacy prediction after pegylated interferon therapy.

Salt stress represses production of extracellular proteases in Bacillus pumilus.

Low-level sequence variation in Toxoplasma gondii calcium-dependent protein kinases among different genotypes.

Efficacy of Artemisia annua polysaccharides as an adjuvant to hepatitis C vaccination.

TNF- -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis.

Codon optimization enhances the expression of porcine ß-defensin-2 in Escherichia coli.

Mangiferin induces cell cycle arrest at G2/M phase through ATR-Chk1 pathway in HL-60 leukemia cells.

Sperm aneuploidy and implications for genetic counseling in a pedigree of three t(1;3) balanced translocation carriers.

Expression analysis of dihydroflavonol 4-reductase genes in Petunia hybrida.

Association of TUSC3 gene polymorphisms with non-syndromic mental retardation based on nuclear families in the Qinba mountain area of China.

Mitochondrial DNA haplogroups and somatic mutations are associated with lung cancer in patients from Southwest China.

Aggressiveness of Pseudocercospora griseola strains in common bean genotypes and implications for genetic improvement.

Acetobacter bacteria are found in Zhenjiang vinegar grains.

BRAF overexpression is associated with BRAF V600E mutation in papillary thyroid carcinomas.

Observed impacts of insulin therapy on callus cell transforming growth factor-beta 1 expression in diabetic rats.

Physiological quality and gene expression during the development of habanero pepper (Capsicum chinense Jacquin) seeds.

Development of novel microsatellite markers in the Korean rockfish Sebastes schlegeli.

Development of a new amplification-refractory mutation system for detection of a single nucleotide polymorphism linked to drug resistance in Ancylostoma caninum.

Association of CHRNA4 gene rs1044396 and rs1044397 polymorphisms with Parkinson's disease symptoms and smoking.

Microsatellite markers for Amazon pellona Pellona castelnaeana (Clupeiformes: Pristigasteridae).

Effects of the Zhikang capsule on healing of the flap after radical breast cancer surgery.

Effect of ultraviolet A exposure on transport of compatible organic osmolytes in human lens epithelial cells.

Molecular cloning, characterization, and expression analysis of a Broad-Complex homolog during development in the oriental river prawn Macrobrachium nipponense.

Genetic structure and diversity in natural and stocked populations of the mandarin fish (Siniperca chuatsi) in China.

Meta-analysis of differentially expressed genes in ankylosing spondylitis.

Cyclin D1 G870A gene polymorphism and risk of leukemia and hepatocellular carcinoma: a meta-analysis.

Effects of changes in serum endostatin and fibroblast growth factor 19 on the chemotherapeutic sensitivity in acute myeloid leukemia patients.

B-type natriuretic peptide and cirrhosis progression.

Association between rs9904341 G

CYP2E1 PstI polymorphism increases cervical neoplasia risk: a meta-analysis.

Association of the TNF- +489 G/A polymorphism with chronic obstructive pulmonary disease risk in Asians: meta-analysis.

Polymorphism of UGT1A1*28 (TA)7 and liver damage in hepatitis B virus-positive patients in Albania.

Genome-wide association with residual body weight gain in Bos indicus cattle.

Allogeneic hematopoietic stem cell transplantation in children with aplastic anemia.

Effect of high-concentrate diet on amino acid transporter expression and milk quality in Holstein dairy cows.

Effect of recombinant human endostatin on the expression of c-Myc and bFGF in mouse gastric cancer cells.

Isolation of microsatellite loci for Rhodiola alsia (Crassulaceae), an important ethno-medicinal herb endemic to the Qinghai-Tibetan plateau.

Characterization and phylogenetic analysis of the swine leukocyte antigen 3 gene from Korean native pigs.

Short Communication: Effect of heat stress on heat-shock protein (Hsp60) mRNA expression in rainbow trout Oncorhynchus mykiss.

Pre-B-cell colony-enhancing factor is markedly elevated in childhood hemophagocytic lymphohistiocytosis.

Clinical analysis of patients with myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis.

Fyn arrests swainsonine-induced apoptosis in 293T cells via Akt and its phosphorylation.

Repeatability and genotypic correlations of reproductive and productive traits of crossbred beef cattle dams.

Investigation of TG gene variants and their effects on growth, carcass composition, and meat quality traits in Chinese steers.

Association between C1GALT1 variants and genetic susceptibility to IgA nephropathy in Uygur.

Fatty acid composition evaluation of edible parts of Eriocheir sinensis in intensive ponds of Gucheng waters.

Expression and role of cyclophilin B in stomach cancer.

Molecular phylogenetics of the white-lipped peccary (Tayassu pecari) did not confirm morphological subspecies in northwestern South America.

Carcass and meat quality traits in Nellore and F1 Nellore-Araguaia crosses.

Relationship between DNA repair gene XPD751 single-nucleotide polymorphisms and prognosis of colorectal cancer.

Effects of docetaxel plus three-dimensional conformal radiation therapy on microvessel density and apoptosis expression in local advanced squamous non-small-cell lung cancer.

Type II deiodinase polymorphisms and serum thyroid hormone levels in patients with mild cognitive impairment.

Immunohistochemical detection and clinicopathological significance of JARID1B/KDM5B and P16 expression in invasive ductal carcinoma of the breast.

Effects of Astragaloside IV on diabetic nephropathy in rats.

Streptomyces ansochromogenes Tur-10 produces a substance with antifungal bioactivity.

Blocking the expression of the hepatitis B virus S gene in hepatocellular carcinoma cell lines with an anti-gene locked nucleic acid in vitro.

Prevalence and genotype distribution of human papillomavirus in women in the Henan Province.

Effect of atorvastatin on diabetic rat endothelial cells and retinal lesions.

Cloning and functional analysis of the promoter of a maize starch synthase III gene (ZmDULL1).

Short Communication: Genetic linkage map of Cucurbita maxima with molecular and morphological markers.

Identification of critical TF-miRNA-mRNA regulation loops for colorectal cancer metastasis.

Ebp1 protein expression in cervical cancer tissue and its significance.

Systematic meta-analysis of the association between monocyte chemoattractant protein-1 -2518A/G polymorphism and risk of tuberculosis.

Ulinastatin promotes T lymphocyte apoptosis in rats with severe acute pancreatitis via mitochondrial pathways.

Serum level of endothelial cell-specific molecule-1 and prognosis of colorectal cancer.

Association between G-217A polymorphism in the AGT gene and essential hypertension: a meta-analysis.

Effects of forkhead box C2 on carcinogenesis and lymphatic metastasis in endometrial carcinoma.

Associations between TNF- polymorphisms and susceptibility to rheumatoid arthritis and vitiligo: a meta-analysis.

Leptin and leptin receptor gene polymorphisms are correlated with production performance in the Arctic fox.

Effects of intravenous analgesia with combined dezocine and butorphanol on postoperative cognitive function in elderly patients.

Variation of plasma levels of endothelin, calcitonin gene-related peptide, nitric oxide, and malondialdehyde in acute myocardial ischemia reperfusion injury in a rabbit model.

Cut-and-paste-based cloning strategy for large gene site-directed mutagenesis.

FSHR gene Thr307Ala and Asn680Ser polymorphisms in infertile men: an association study in North China and meta-analysis.

Clinical significance of SHMT1 rs1979277 polymorphism in Asian solid tumors: evidence from a meta-analysis.

Polymorphisms in a myostatin gene and associations with growth in a hybrid of Culter alburnus and Ancherythroculter nigrocauda.

Autophagy in drug resistance of the multiple myeloma cell line RPMI8226 to doxorubicin.

Ara-C and anti-CD47 antibody combination therapy eliminates acute monocytic leukemia THP-1 cells in vivo and in vitro.

Well-balanced commensal microbiota contributes to anti-cancer response in a lung cancer mouse model.

Human leukocyte antigen-B27 alleles in Xinjiang Uygur patients with ankylosing spondylitis.

Genetic diversity of Ceratoides arborescens, a species endemic to China, detected by inter-simple sequence repeat (ISSR).

Development of RAPD-SCAR markers for different Ganoderma species authentication by improved RAPD amplification and molecular cloning.

Limitations of cytochrome oxidase I for the barcoding of Neritidae (Mollusca: Gastropoda) as revealed by Bayesian analysis.

Disease indicators for sepsis and analysis of sepsis treatment in children using the continuous blood purification technique.

Development and characterization of microsatellite markers via cross-species amplification of Paramisgurnus dabryanus.

Value of human brain natriuretic peptide in treatment of acute anterior myocardial infarction evaluated via three-dimensional speckle tracking imaging.

Three branches of phospholipase C signaling pathway promote hepatocyte growth in rat liver regeneration.

Impact of caffeine on ß cell proliferation and apoptosis under the influence of palmitic acid.

Screening relevant genes of tolerance to low phosphorus in maize using cDNA-amplified fragment length polymorphism.

PUMA gene transfection can enhance the sensitivity of epirubicin-induced apoptosis of MCF-7 breast cancer cells.

Molecular cloning and characterization of a novel Y-box gene from Sepiella maindroni.

Genetic potential of common bean progenies selected for crude fiber content obtained through different breeding methods.

Entoepidemiology of Chagas disease in the Western region of the State of São Paulo from 2004 to 2008, and cytogenetic analysis in Rhodnius neglectus (Hemiptera, Triatominae).

Relevance of E-cadherin expression to EGFR-TKI molecular targeted therapy sensitivity/resistance and its clinical significance.

Effect of Rhizoma paridis total saponins on apoptosis of colorectal cancer cells and imbalance of the JAK/STAT3 molecular pathway induced by IL-6 suppression.

Correlation between ERCC1 expression and concurrent chemotherapy and radiotherapy in patients with locally advanced nasopharyngeal cancer.

Characterization of Ty1/copia-like retrotransposon families from pigeonpea genome.

Predictive value of CK20 in evaluating the efficacy of treatment and prognosis after surgery for colorectal cancer.

Abundance and diversity of sulfate-reducing bacteria in the sediment of the Zhou Cun drinking water reservoir in Eastern China.

Cluster analysis of Pinus taiwanensis for its ex situ conservation in China.

Cyclin D1 G870A polymorphism is associated with an increased risk of multiple myeloma.

A case-control study on the risk factors of urinary calculus in Uyghur children in the Kashi region.

Assessment of genetic diversity in lentils (Lens culinaris Medik.) based on SNPs.

Assessing hygienic behavior of Apis mellifera unicolor (Hymenoptera: Apidae), the endemic honey bee from Madagascar.

Development of novel polymorphic microsatellite markers for the silver fox (Vulpes vulpes).

Expression of hypoxia-inducible factor-1 during ovarian follicular growth and development in Sprague-Dawley rats.

Genomic cloning, expression, and single nucleotide polymorphism association analysis of the insulin-like androgenic gland hormone gene in the oriental river prawn (Macrobrachium nipponense).

Association between ß1 adrenergic receptor gene Arg389Gly polymorphism and risk of heart failure: a meta-analysis.

Molecular cloning, characterization and expression analysis of a Doublesex gene from Daphnia carinata (Crustacea: Cladocera) during different reproductive stages.

DNA barcoding and phylogenetic relationships in Timaliidae.

Population structure and genetic variation of the endangered species Elaeagnus mollis Diels (Elaeagnaceae).

Genetic relationships analysis of olive cultivars grown in China.

Proteomic analysis revealed the altered kidney protein profile of a Cyld knockout mouse model.

Effect of leukocyte filtration on the P-selectin expression of apheresis platelets.

Genetic polymorphisms in the carbonic anhydrase VI gene and dental caries susceptibility.

Proapoptotic effects of heme oxygenase-1 inhibitor on Kasumi-1 cells via the ATF4/CHOP/Ire-1 pathway.

Molecular cloning and bioinformatic analysis of the Streptococcus agalactiae neuA gene isolated from tilapia.

Effect of Xin Mai Jia on atherosclerosis in rats.

Integrated miRNA-mRNA analysis of Epstein-Barr virus-positive nasopharyngeal carcinoma.

Polymorphisms in different EST-SSR types derived from the Chinese bayberry Myrica rubra, Myricaceae) transcriptome.

Correlation analysis between single nucleotide polymorphism of DRD1 gene and stereotyped behavior of blue fox.

Association between polymorphisms in exons 4 and 10 of the BPI gene and immune indices in Sutai pigs.

Comparison between meat quality of Hanzhong White pigs and carcass weight.

Impact of enteral nutrition on postoperative immune function and nutritional status.

Characterization and expression analysis of Toll-like receptor 3 cDNA from Atlantic salmon (Salmo salar).

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity.

BORIS and CTCF are overexpressed in squamous intraepithelial lesions and cervical cancer.

Analysis of quantitative trait loci for main plant traits in soybean.

Association analysis between SNPs in the 5'-flanking region of the chicken GRP78 gene, thermotolerance parameters, and tissue mRNA expression.

Genetic variation detected by RAPD markers in natural populations of babassu palm (Attalea speciosa Mart.).

Association between TNFSF4 tagSNPs and myocardial infarction in a Chinese Han population.

Application of vacuum-assisted closure in seawater-immersed wound treatment under different negative pressures.

Vitamin D receptor FokI gene polymorphism and tuberculosis susceptibility: a meta-analysis.

Mutation analyses and prenatal diagnosis in families of X-linked severe combined immunodeficiency caused by IL2RÎ³ gene novel mutation.

Analysis of the GSTM1-null polymorphism in patients with pterygium from Goiânia, Goiás Brazil.

Pterygium in patients from Goiânia, Goiás, Brazil.

De novo assembly and characterization of the root transcriptome and development of simple sequence repeat markers in Paphiopedilum concolor.

Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin.

Genetic polymorphism at the KIR gene locus: determination of gene, genotype, and haplotype frequencies in the Xinjiang Han population.

Bovine yolk sac: from morphology to metabolomic and proteomic profiles.

Expression of COX-2 and VEGF-C in cholangiocarcinomas at different clinical and pathological stages.

Case Report Diffuse large B-cell lymphoma in the primary bone marrow.

Antioxidant content and cytological examination of aqueous fluid from patients with age-related cataracts at different stages.

Association between the FCGR2A gene H131R polymorphism and risk of Kawasaki disease: a meta-analysis.

Novel polymorphic microsatellite markers in Odontobutis potamophila.

Hypolipidemic effect of safflower yellow and primary mechanism analysis.

Polymorphisms in the PPARÎ³ gene and their association with metabolic syndrome in Uyghurs and Kazakhs from Xinjiang, China.

Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population.

Karyotype of Philodryas nattereri and Philodryas olfersii with a comparative analysis of the Dipsadidae family.

Estimating additive and dominance variances for complex traits in pigs combining genomic and pedigree information.

DKK1 eukaryotic expression plasmid and expression product identification.

Screening the first set of polymorphic microsatellite loci in Lunella coronata granulata (Turbinidae).

Assessment of the cytotoxic, genotoxic, and antigenotoxic activities of sucupira oil (Pterodon emarginatus).

Association of MDR1 C3435T and C1236T single nucleotide polymorphisms with male factor infertility.

Dynamic changes of virus load in supernatant of primary CEK cell culture infected with different generations of avian infectious bronchitis virus strains Sczy3 as revealed by real-time reverse transcription-polymerase chain reaction.

Positive association between PPARD rs2016520 polymorphism and coronary heart disease in a Han Chinese population.

Activity of matrix metalloproteinases 2 and 9 in cultured rabbit corneal epithelium cells stimulated by tumor necrosis factor alpha.

A simplified genomic DNA extraction protocol for pre-germination genotyping in rice.

FlgN plays important roles in the adhesion of Aeromonas hydrophila to host mucus.

Effect of Ginkgo biloba extract on apoptosis of brain tissues in rats with acute cerebral infarction and related gene expression.

Repair of large segmental bone defects in rabbits using BMP and FGF composite xenogeneic bone.

Effects of exogenous 5-aminolevulinic acid on photosynthesis, stomatal conductance, transpiration rate, and PIP gene expression of tomato seedlings subject to salinity stress.

Inhibition of human chronic myelogenous leukemia K562 cell growth following combination treatment with resveratrol and imatinib mesylate.

Identification and characterization of novel NBS-LRR resistance gene analogues from the pea.

Genome-wide pathway analysis in amyotrophic lateral sclerosis.

Characterization of Aspergillus niger endo-1,4-ß-glucanase ENG1 secreted from Saccharomyces cerevisiae using different expression vectors.

Assessment of apple core collections constructed using phenotypic and genotypic data.

Polymorphisms in GSTM1, GSTT1, GSTP1, and GSTM3 genes and breast cancer risk in northeastern Mexico.

Population genetic structure of Attalea vitrivir Zona (Arecaceae) in fragmented areas of southeast Brazil.

Study of the obp5 gene in Apis mellifera ligustica and Apis cerana cerana.

Phenotypic variation and diversity of Magnolia sprengeri Pamp. in native habitat.

Genetic diversity in elite inbred lines of maize and its association with heterosis.

Qualitative analysis of the vaginal microbiota of healthy cattle and cattle with genital-tract disease.

Isolation and characterization of polymorphic microsatellite loci in the sea cucumber Holothuria scabra.

IDH1 and IDH2 mutations in different histologic subtypes and WHO grading gliomas in a sample from Northern Brazil.

Decreased TIM-3 mRNA expression in peripheral blood mononuclear cells from nephropathy patients.

Cloning and association analysis of KIT and EDNRB polymorphisms with dominant white coat color in the Chinese raccoon dog (Nyctereutes procyonoides procyonoides).

Screening and characterization of novel polymorphic microsatellite markers from sea cucumber Holothuria leucospilota.

Apelin polymorphism predicts blood pressure response to losartan in older Chinese women with essential hypertension.

Osteoprotegerin polymorphisms in Chinese Han patients with rheumatoid arthritis.

Association of miR-21 with esophageal cancer prognosis: a meta-analysis.

Varicocele and male infertility in Northeast China: Y chromosome microdeletion as an underlying cause.

Recombinant adenovirus-mediated overexpression of PTEN and KRT10 improves cisplatin resistance of ovarian cancer in vitro and in vivo.

Partial least squares-based gene expression analysis in preeclampsia.

FOXO1 is a tumor suppressor in cervical cancer.

Clinical features and treatment of endophthalmitis after cataract surgery.

Karyotype structure of Hypostomus cf. plecostomus (Linnaeus, 1758) from Tapajós River basin, Southern Amazon: occurrence of sex chromosomes (ZZ/ZW) and their evolutionary implications.

Association between IL-1ß, IL-8, and IL-10 polymorphisms and risk of acute pancreatitis.

Effect of morphine preconditioning in the delayed phase on the expression of p38 mitogen-activated protein kinase in a rabbit model of myocardial ischemia-reperfusion injury.

Effects of goal-directed fluid therapy with different lactated Ringer's: hydroxyethyl starch ratios in hemorrhagic shock dogs.

Non-invasive determination of the immune physiological state of reindeer (Rangifer tarandus) in the Greater Khingan Mountains, China.

Case Report Unicentric Castleman disease located in the anterior mediastinum misdiagnosed as invasive thymoma: a case report.

Development and characterization of new microsatellite markers of Fenneropenaeus penicillatus.

Construction of an integrated genetic map for Capsicum baccatum L.

Improving plant transformation using Agrobacterium tumefaciens.

Association between FTO polymorphism in exon 3 with carcass and meat quality traits in crossbred ducks.

Hypoxia-inducible factor-1 expression in the different stages of rat thromboangiitis obliterans.

Detection of drug-resistance mechanism of Pseudomonas aeruginosa developing from a sensitive strain to a persister during carbapenem treatment.

Relationship between zinc finger protein 36 (ZFP36) gene polymorphisms and obstructive sleep apnea.

Multi-objective optimization in systematic conservation planning and the representation of genetic variability among populations.

Correlation between promoter methylation in the GSTP1 gene and hepatocellular carcinoma development: a meta-analysis.

Differential gene expression in pre-laying and laying period ovaries of Sichuan White geese (Anser cygnoides).

QTLs for rice flag leaf traits in doubled haploid populations in different environments.

Artificial neural networks reveal efficiency in genetic value prediction.

Identification of smut-responsive genes in sugarcane using cDNA-SRAP.

Cloning and expression of an APETALA1-like gene from Nelumbo nucifera.

Clinical and pathological features and treatment of AIDS-related cutaneous Kaposi's sarcoma in Chinese Han patients.

Association between interleukin gene polymorphisms and risk of recurrent oral ulceration.

Expression and significance of S100P, CD147, and OCT4 in different prostate cancer tissue TNM stages.

Expression of TNF- , VEGF, and MMP-3 mRNAs in synovial tissues and their roles in fibroblast-mediated osteogenesis in ankylosing spondylitis.

Association of cytokine gene polymorphisms with susceptibility to invasive candidiasis.

Intracranial aneurysm risk factor genes: relationship with intracranial aneurysm risk in a Chinese Han population.

Investigation of Sclerotinia sclerotiorum strains variability in Brazil.

Screening for fragile X syndrome in males from specialized institutions in the northeast region of Brazil.

Development and cross-species transferability of unigene-derived microsatellite markers in an edible oil woody plant, Camellia oleifera (Theaceae).

Diadenylate cyclase evaluation of ssDacA (SSU98_1483) in Streptococcus suis serotype 2.

Brief Note Low diversity of the major histocompatibility complex class II DRA gene in domestic goats (Capra hircus) in Southern China.

Mechanisms of cytotoxicity induced by the anesthetic isoflurane: the role of inositol 1,4,5-trisphosphate receptors.

Decreased microRNA-143 expression and its tumor suppressive function in human oral squamous cell carcinoma.

Clinical significance and levels of blood brain natriuretic peptides in patients with persistent atrial fibrillation before and after catheter ablation.

PDIA3 and PDIA6 gene expression as an aggressiveness marker in primary ductal breast cancer.

Inhibition of adipogenic differentiation of bone marrow mesenchymal stem cells by erythropoietin via activating ERK and P38 MAPK.

WY14643 combined with all-trans retinoic acid acts via p38 MAPK to induce 'browning' of white adipocytes in mice.

Effects of conjugated linoleic acid on the expression levels of miR-27 and miR-143 in pig adipose tissue.

Expression profile of tumor suppressor gene RASSF1 in lacrimal gland carcinoma.

Verification and characterization of chromosome duplication in haploid maize.

IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis.

Construction of a gene-gene interaction network with a combined score across multiple approaches.

Regulating effects of insertion direction of matrix attachment regions on transgenic expression in stably transformed Chinese hamster ovary cells.

Immunomodulatory effect of bone marrow mesenchymal stem cells on T lymphocytes in patients with decompensated liver cirrhosis.

Relationship between genetic polymorphisms of DNA ligase 1 and non-small cell lung cancer susceptibility and radiosensitivity.

Expression and clinical significance of PIWIL2 in hilar cholangiocarcinoma tissues and cell lines.

Sublingual vein parameters, AFP, AFP-L3, and GP73 in patients with hepatocellular carcinoma.

Construction of overexpression vectors of Magnaporthe oryzae genes BAS1 and BAS4 fusion to mCherry and screening of overexpression strains.

Identification and expression analysis of YABBY family genes associated with fruit shape in tomato (Solanum lycopersicum L.).

A novel variant of the ß-lactamase ADC-61 gene in multi-drug resistant Acinetobacter baumannii.

Correlation between the genetic polymorphism of ORMDL3 gene and asthma risk: a meta-analysis.

Expression of glyceraldehyde 3-phosphate dehydrogenase is enhanced in Leishmania spp naturally resistant to nitric oxide.

Association between XRCC1 Arg280His polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis.

Impact of early enteral and parenteral nutrition on prealbumin and high-sensitivity C-reactive protein after gastric surgery.

Impact of early postoperative enteral nutrition on clinical outcomes in patients with gastric cancer.

Analysis of postoperative PSA changes after ultrasound-guided permanent [125I] seed implantation for the treatment of prostate cancer.

Reaction norms for the study of genotype-environment interaction for growth and indicator traits of sexual precocity in Nellore cattle.

Immunohistochemistry of lymphocytes in benign lymphoadenosis of oral mucosa.

Flow cytometry reliability analysis and variations in sugarcane DNA content.

Cloprostenol and pregnant mare serum gonadotropin promote estrus synchronization, uterine development, and follicle-stimulating hormone receptor expression in mice.

Differential gene expression in drought-tolerant sugarcane roots.

Anti-prostate cancer effects of CTL cell induction in vitro by recombinant adenovirus mediated PSMA/4-1BBL dendritic cells: an immunotherapy study.

Potential hippocampal genes and pathways involved in Alzheimer's disease: a bioinformatic analysis.

Expression and clinical value of the soluble major histocompatibility complex class I-related chain A molecule in the serum of patients with renal tumors.

Correlation of UGT1A1 and ERCC1 gene polymorphisms with the outcome of combined irinotecan plus cisplatin treatment in recurrent ovarian cancer.

PPARÎ³ Pro12Ala and His447His polymorphisms and susceptibility to Alzheimer's disease: a meta-analysis.

Ion beam transformation with corn DNA alters proteinase expression in rice seedling roots.

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Potential hippocampal genes and pathways involved in Alzheimer's disease: a bioinformatic analysis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, L. Guo, X. Q. Yan, Z. R. Li, Y. Z. Chu, J. F. Zhang, X.
Description	Country affiliation: China Author Affiliation: Zhang L ( Department of Neurology, Shandong Ji'ning No. 1 People' Hospital, Ji'ning, China.); Guo XQ ( Department of Neurology, Shandong Ji'ning No. 1 People' Hospital, Ji'ning, China.); Chu JF ( Department of Neurology, Shandong Ji'ning No. 1 People' Hospital, Ji'ning, China.); Zhang X ( Department of Neurology, Shandong Ji'ning No. 1 People' Hospital, Ji'ning, China.); Yan ZR ( Department of Neurology, Shandong Ji'ning No. 1 People' Hospital, Ji'ning, China.); Li YZ ( Department of Neurology, Shandong Ji'ning No. 1 People' Hospital, Ji'ning, China yuzhi_li@yeah.net.)
Abstract	Alzheimer's disease (AD) is a neurodegenerative disor-der and the most common cause of dementia in elderly people. Nu-merous studies have focused on the dysregulated genes in AD, but the pathogenesis is still unknown. In this study, we explored critical hippocampal genes and pathways that might potentially be involved in the pathogenesis of AD. Four transcriptome datasets for the hip-pocampus of patients with AD were downloaded from ArrayExpress, and the gene signature was identified by integrated analysis of mul-tiple transcriptomes using novel genome-wide relative significance and genome-wide global significance models. A protein-protein interaction network was constructed, and five clusters were selected. The biologi-cal functions and pathways were identified by Gene Ontology and Kyo-to Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. A total of 6994 genes were screened, and the top 300 genes were subjected to further analysis. Four significant KEGG pathways were identified, including oxidative phosphorylation and Parkinson's disease, Huntington's disease, and Alzheimer's disease pathways. The hub network of cluster 1 with the highest average rank value was de-fined. The genes (NDUFB3, NDUFA9, NDUFV1, NDUFV2, NDUFS3, NDUFA10, COX7B, and UQCR1) were considered critical with high degree in cluster 1 as well as being shared by the four significant path-ways. The oxidative phosphorylation process was also involved in the other three pathways and is considered to be relevant to energy-related AD pathology in the hippocampus. This research provides a perspec-tive from which to explore critical genes and pathways for potential AD therapies.
e-ISSN	16765680
Journal	Genetics and Molecular Research
Issue Number	2
Volume Number	14
Language	English
Publisher	Fundação de Pesquisas Científicas de Ribeirão Preto
Publisher Date	2015-06-29
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Alzheimer Disease Genetics Gene Regulatory Networks Hippocampus Metabolism Nerve Tissue Proteins Transcriptome Pathology Case-control Studies Computational Biology Gene Expression Regulation Molecular Sequence Annotation Oxidative Phosphorylation Protein Interaction Mapping Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics
Content Type	Text
Resource Type	Article

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