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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Li, S. Chen, L-L Lu, W-S Li, Y-S Guo, W-W |
| Description | Country affiliation: China Author Affiliation: Lu WS ( Medical College of Jinan University, Guanzhou, Guangdong Province, China.); Li S ( Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, Guangdong Province, China.); Guo WW ( Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, Guangdong Province, China.); Chen LL ( Medical College of Jinan University, Guanzhou, Guangdong Province, China.); Li YS ( Medical College of Jinan University, Guanzhou, Guangdong Province, China syzyklys@126.com.) |
| Abstract | The aims of this study were to explore the effects of Astragaloside IV on diabetic nephropathy (DN) rats. A total of 38 male Sprague-Dawley (SD) rats were divided into three groups: 10 in the normal (control) group, 14 in the DN model group, and 14 in the AS-IV group. Treatment began one week after the streptozotocin DN model was successfully established. Blood glucose and urine micro-albumin levels were measured every four weeks. After being treated for 12 weeks, all SD rats were sacrificed for blood and renal specimen collec-tion. Renal cortex specimens were observed after hematoxylin and eo-sin and Masson staining. Expression levels of protein ß1, ß1-integrin-linked protein kinase (ILK) and -actinin-4 were also measured. After eight weeks of intervention, blood glucose levels in the AS-IV group decreased significantly when compared with those of the model group (P < 0.01). By the end of the twelfth week, the urine micro-albumin levels showed significant differences (P < 0.01) between the AS-IV and model groups, and the expression levels of integrin ß1, ILK, and -actinin-4 also showed significant differences (P < 0.05, respectively). Concomitantly, expression levels of integrin ß1, ILK, and -actinin-4 in the model group were significantly different from those of normal group (P < 0.05). These results suggest that AS-IV can be quite effective in decreasing blood glucose levels, reducing urine albumin excretion, and improving the adhesion function of potocytes, and can thus delay the development of DN. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 2 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-05-22 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Diabetes Mellitus, Experimental Drug Therapy Diabetic Nephropathies Saponins Administration & Dosage Triterpenes Actinin Genetics Animals Antigens, Cd29 Pathology Gene Expression Regulation Kidney Drug Effects Protein-serine-threonine Kinases Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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