NDLI: Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats.

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Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats.

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Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Min, Xinwen Zhao, Libin He, Peigen Wang, Neng Li, Dongfeng
Description	Author Affiliation: Wang N ( Department of Cardiology, Dongfeng Hospital of Hubei Medical University, Shiyan, Hubei 442008, PR China. wangneng0701@163.com)
Abstract	The high mobility group box 1 (HMGB1) protein plays an important role in myocardial ischemia and reperfusion (I/R) injury. Geranylgeranylacetone (GGA), a heat shock protein 72 inducer, has been reported to reduce myocardial I/R injury. The aim of this study was to investigate the cardioprotective mechanism of GGA during myocardial I/R injury in rats. Anesthetized male rats were treated once with GGA (200 mg/kg, p.o.) 24 h before ischemia, and subjected to ischemia for 30 min, followed by reperfusion for 4 h. Lactate dehydrogenase (LDH), creatine kinase (CK), malondialdehyde (MDA), superoxide dismutase (SOD) activity and infarct size were measured. HMGB1 expression was assessed by immunoblotting. The results showed that pre-treatment with GGA (200 mg/kg) significantly reduced the infarct size and the levels of LDH and CK after 4 h of reperfusion (all P<0.05). GGA also significantly inhibited the increase in MDA levels and the decrease in SOD levels (both P<0.05). Meanwhile, GGA considerably suppressed the expression of HMGB1 induced by I/R. The present study suggests that GGA is capable of attenuating myocardial I/R injury by inhibiting HMGB1 expression.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	2
Volume Number	5
Language	English
Publisher	Spandidos Publications
Publisher Date	2012-02-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Cardiotonic Agents Pharmacology Diterpenes Gene Expression Regulation Drug Effects Hmgb1 Protein Antagonists & Inhibitors Myocardial Ischemia Prevention & Control Reperfusion Injury Animals Therapeutic Use Creatine Kinase Metabolism Hsp72 Heat-shock Proteins L-lactate Dehydrogenase Malondialdehyde Rats, Sprague-dawley Superoxide Dismutase Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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