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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shi, G. L. Sun, Y. Song, C. X. Yang, L. Yin, Y. J. |
| Description | Country affiliation: China Author Affiliation: Shi GL ( Department of Clinical Immunology Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.); Yang L ( Department of Clinical Immunology Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.); Sun Y ( Department of Clinical Immunology Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.); Yin YJ ( Department of Clinical Immunology Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.); Song CX ( Department of Clinical Immunology Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China songchangx@sina.com.) |
| Abstract | Pulmonary tuberculosis (PTB) remains one of the most important infectious diseases worldwide. Several studies have suggested that genetic factors may affect the susceptibility to PTB, but the specific genes involved have not been fully characterized. The gene for monocyte chemoattractant protein 1 (MCP-1) has been linked to an increased risk of tuberculosis in some Mexican and Korean populations. To explore the role of the MCP-1 gene in the susceptibility to PTB in a North Chinese population, we evaluated the association between MCP-1 -2518A/G gene polymorphisms and the risk for tuberculosis. Polymerase chain reaction amplification of genomic DNA followed by restriction fragment length polymorphism analysis was used. There was a significant increase in the frequency of the GG genotype of MCP-1 -2518 in 136 patients with PTB compared to that in 152 healthy controls (P = 0.008, X(2) = 7.133, odds ratio = 1.96). Similarly, the frequencies of the A/G alleles in the 2 groups differed; the frequency of allele G was higher in patients with PTB (P = 0.011, X(2) = 6.428, odds ratio = 1.536). In conclusion, the -2518A/G polymorphism in the MCP-1 gene was found to be associated with an increased susceptibility to PTB in a North Chinese population. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 2 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-04-27 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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