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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhuang, Liujing Zhang, Bin Hu, Liang Qin, Zhen Wang, Ping Hu, Ning |
| Description | Country affiliation: China Author Affiliation: Qin Z ( Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China); Zhang B ( Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China.); Hu L ( Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China.); Zhuang L ( Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China.); Hu N ( Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China); Wang P ( Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China) |
| Abstract | Animals' gustatory system has been widely acknowledged as one of the most sensitive chemosensing systems, especially for its ability to detect bitterness. Since bitterness usually symbolizes inedibility, the potential to use rodent's gustatory system is investigated to detect bitter compounds. In this work, the extracellular potentials of a group of neurons are recorded by chronically coupling microelectrode array to rat's gustatory cortex with brain-machine interface (BMI) technology. Local field potentials (LFPs), which represent the electrophysiological activity of neural networks, are chosen as target signals due to stable response patterns across trials and are further divided into different oscillations. As a result, different taste qualities yield quality-specific LFPs in time domain which suggests the selectivity of this in vivo bioelectronic tongue. Meanwhile, more quantitative study in frequency domain indicates that the post-stimulation power of beta and low gamma oscillations shows dependence with concentrations of denatonium benzoate, a prototypical bitter compound, and the limit of detection is deduced to be 0.076 µM, which is two orders lower than previous in vitro bioelectronic tongues and conventional electronic tongues. According to the results, this in vivo bioelectronic tongue in combination with BMI presents a promising method in highly sensitive bitterness detection and is supposed to provide new platform in measuring bitterness degree. |
| ISSN | 09565663 |
| Volume Number | 78 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-04-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Electrophysiology Methods Quaternary Ammonium Compounds Isolation & Purification Taste Perception Animals Brain-computer Interfaces Nerve Net Chemistry Physiology Neurons Rats Taste Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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