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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hsia, K. Jimmy Liu, Qingjun Zhang, Fenni Zhang, Diming Wang, Hua Wang, Ping Hu, Ning |
| Description | Author Affiliation: Liu Q ( Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China.) |
| Abstract | Taste has received great attention for its potential applications. In this work, we combine the biological tissue with micro-chips to establish a novel bioelectronic tongue system for salt taste detection. Before experiment, we established a computational model of action potential in salt taste receptor cell, simulating the responsive results to natural salt stimuli of NaCl solution with various concentrations. Then 36-channel microelectrode arrays (MEA) with the diameter of 30 µm were fabricated on the glass substrate, and taste epithelium was stripped from rat and fixed on MEA. When stimulated by the salt stimuli, electrophysiological activities of taste receptor cells in taste buds were measured through a multi-channel recording system. Both simulation and experiment results showed a dose-dependent increase in NaCl-induced potentials of taste receptor cells, which indicated good applications in salt measurements. The multi-channel analysis demonstrated that different groups of MEA channels were activated during stimulations, indicating non-overlapping populations of receptor cells in taste buds involved in salt taste perception. The study provides an effective and reliable biosensor platform to help recognize and distinguish salt taste components. |
| ISSN | 09565663 |
| Issue Number | 1 |
| Volume Number | 40 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-02-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Bioartificial Organs Biological Assay Instrumentation Microelectrodes Sodium Chloride Analysis Pharmacology Taste Buds Physiology Taste Animals Biomimetic Materials Biosensing Techniques Conductometry Electronics Equipment Design Equipment Failure Analysis Humans In Vitro Techniques Rats Rats, Sprague-dawley Reproducibility Of Results Sensitivity And Specificity Drug Effects Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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