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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lorenzetti, G. Mannini, M. Dini, V. Lomonaco, T. Scataglini, I. Salvo, P. Calisi, N. Fuoco, R. Paoletti, C. Romanelli, M. Di Francesco, F. Melai, B. Paolicchi, A. Cortigiani, B. Caneschi, A. |
| Description | Country affiliation: Italy Author Affiliation: Salvo P ( Institute of Clinical Physiology, National Council of Research (IFC-CNR), Via Moruzzi 1, 56124 Pisa, Italy); Calisi N ( Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy.); Melai B ( Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy.); Cortigiani B ( INSTM, National Interuniversity Consortium of Materials Science and Technology, Via G. Giusti 9, 50121 Firenze, Italy); Mannini M ( INSTM, National Interuniversity Consortium of Materials Science and Technology, Via G. Giusti 9, 50121 Firenze, Italy); Caneschi A ( INSTM, National Interuniversity Consortium of Materials Science and Technology, Via G. Giusti 9, 50121 Firenze, Italy); Lorenzetti G ( Applied and Laser Spectroscopy Laboratory, ICCOM-CNR, Research Area of Pisa, Via G. Moruzzi 1, 56124 Pisa, Italy.); Paoletti C ( Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy.); Lomonaco T ( Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy.); Paolicchi A ( Department of Experimental Pathology, University of Pisa Medical School, Via Roma 55, Pisa 56126, Italy.); Scataglini I ( Department of Experimental Pathology, University of Pisa Medical School, Via Roma 55, Pisa 56126, Italy.); Dini V ( Wound Healing Research Unit, Department of Dermatology, University of Pisa, Via Roma 67, 56126 Pisa, Italy.); Romanelli M ( Wound Healing Research Unit, Department of Dermatology, University of Pisa, Via Roma 67, 56126 Pisa, Italy.); Fuoco R ( Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy.); Di Francesco F ( Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy) |
| Abstract | Point-of-care applications and patients' real-time monitoring outside a clinical setting would require disposable and durable sensors to provide better therapies and quality of life for patients. This paper describes the fabrication and performances of a temperature and a pH sensor on a biocompatible and wearable board for healthcare applications. The temperature sensor was based on a reduced graphene oxide (rGO) layer that changed its electrical resistivity with the temperature. When tested in a human serum sample between 25 and 43°C, the sensor had a sensitivity of 110±10â ¦/°C and an error of 0.4±0.1°C compared with the reference value set in a thermostatic bath. The pH sensor, based on a graphene oxide (GO) sensitive layer, had a sensitivity of 40±4mV/pH in the pH range between 4 and 10. Five sensor prototypes were tested in a human serum sample over one week and the maximum deviation of the average response from reference values obtained by a glass electrode was 0.2pH units. For biological applications, the temperature and pH sensors were successfully tested for in vitro cytotoxicity with human fibroblast cells (MRC-5) over 24h. |
| ISSN | 09565663 |
| Volume Number | 91 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-05-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Instrumentation Blood Chemical Analysis Graphite Chemistry Thermometers Cell Line Cell Survival Equipment Design Fibroblasts Cytology Humans Hydrogen-ion Concentration Materials Testing Oxidation-reduction Oxides Temperature Journal Article Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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