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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yoon, Jang-Hee Choi, Cheol Soo Kim, Dong-Min Shim, Yoon-Bo Lee, Won-Chul Moon, Jong-Min |
| Description | Country affiliation: South Korea Author Affiliation: Kim DM ( Department of Chemistry, Institute of Bio Physio Sensor Technology (IBST), Pusan National University, Busan 46241, South Korea.); Moon JM ( Department of Chemistry, Institute of Bio Physio Sensor Technology (IBST), Pusan National University, Busan 46241, South Korea.); Lee WC ( Department of Chemistry, Institute of Bio Physio Sensor Technology (IBST), Pusan National University, Busan 46241, South Korea.); Yoon JH ( Busan center, Korea Basic Science Institute, Busan 46742, South Korea.); Choi CS ( Department of Internal Medicine, Gil Medical Center, Gachon University Graduate School of Medicine, Incheon, South Korea.); Shim YB ( Department of Chemistry, Institute of Bio Physio Sensor Technology (IBST), Pusan National University, Busan 46241, South Korea. Electronic address: ybshim@pusan.ac.kr.) |
| Abstract | A non-enzymatic potentiometric glucose sensor for the determination of glucose in the micomolar level in saliva was developed based on a molecularly imprinted polymer (MIP) binding on a conducting polymer layer. A MIP containing acrylamide, and aminophenyl boronic acid, as a host molecule to glucose, was immobilized on benzoic acid-functionalized poly(terthiophene) (pTBA) by the amide bond formation onto a gold nanoparticles deposited-screen printed carbon electrode (pTBA/AuNPs/SPCE). Aromatic boronic acid was incorporated into the MIP layer to stably capture glucose and create a potentiometric signal through the changed pKa value of polymer film by the formation of boronate anion-glucose complex with generation of H ions by the cis-diol reaction. Reversible binding and extraction of glucose on the sensor surface was observed using a quartz crystal microbalance. Each layer of the sensor probe was characterized by cyclic voltammetry, electrochemical impedance spectroscopy, X-ray photoelectron spectroscopy, and atomic force microscopy. The potentiometric response at the optimized conditions exhibited a wide linear dynamic range of 3.2×10 to 1.0×10 M, with a detection limit of 1.9 (±0.15)×10 M. The sensor probe revealed an excellent selectivity and sensitivity for glucose compared to other saccharides. In addition, the reliability of the proposed glucose sensor was evaluated in physiological fluid samples of saliva and finger prick blood. |
| ISSN | 09565663 |
| Journal | Biosensors and Bioelectronics |
| Volume Number | 91 |
| e-ISSN | 18734235 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-05-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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