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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Seo, Dong Han Yick, Samuel Lawn, Malcolm Han, Zhao Jun Pineda, Shafique Borghi, Fabricio Frizera Ostrikov, Kostya Ken Van Der Laan, Timothy |
| Description | Country affiliation: Australia Author Affiliation: Pineda S ( CSIRO Manufacturing, P.O. Box 218, 36 Bradfield Road, Lindfield, NSW 2070, Australia); Borghi FF ( CSIRO Manufacturing, P.O. Box 218, 36 Bradfield Road, Lindfield, NSW 2070, Australia); Seo DH ( CSIRO Manufacturing, P.O. Box 218, 36 Bradfield Road, Lindfield, NSW 2070, Australia.); Yick S ( CSIRO Manufacturing, P.O. Box 218, 36 Bradfield Road, Lindfield, NSW 2070, Australia.); Lawn M ( National Measurement Institute (NMI), Nanometrology, 36 Bradfield Road, Lindfield, NSW 2070, Australia.); van der Laan T ( CSIRO Manufacturing, P.O. Box 218, 36 Bradfield Road, Lindfield, NSW 2070, Australia); Han ZJ ( CSIRO Manufacturing, P.O. Box 218, 36 Bradfield Road, Lindfield, NSW 2070, Australia.); Ostrikov KK ( CSIRO Manufacturing, P.O. Box 218, 36 Bradfield Road, Lindfield, NSW 2070, Australia) |
| Abstract | Here, we present a rapid, low-temperature (200°C) plasma-enabled synthesis of graphene micro-islands (GMs). Morphological analyses of GMs by scanning electron microscopy (SEM) and atomic force microscopy (AFM) feature a uniform and open-networked array of aggregated graphene sheets. Structural and surface chemical characterizations by Raman spectroscopy and X-ray photoelectron spectroscopy (XPS) support the presence of thin graphitic edges and reactive oxygen functional groups. We demonstrate that these inherent properties of GMs enable its multifunctional capabilities as a bioactive interface. GMs exhibit a biocompatibility of 80% cell viability with primary fibroblast lung cells after 5 days. Further, GMs were assembled into an impedimetric genosensor, and its performance was characterized by electrochemical impedance spectroscopy (EIS). A dynamic sensing range of 1pM to 1nM is reported, and a limit of quantification (LOQ) of 2.03×10 M is deduced, with selectivity to single-RNA-base mismatched sequences. The versatile nature of GMs may be explored to enable multi-faceted bioactive platforms for next-generation personalized healthcare technologies. |
| ISSN | 09565663 |
| Issue Number | Pt 1 |
| Volume Number | 89 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-03-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biocompatible Materials Chemistry Biosensing Techniques Methods Graphite Micrornas Analysis Nanostructures Plasma Gases Cell Line Cell Survival Cold Temperature Dielectric Spectroscopy Fibroblasts Cytology Humans Ultrastructure Journal Article Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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