NDLI: Continuous minimally-invasive alcohol monitoring using microneedle sensor arrays.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Windmiller, Joshua Ray Mishra, Rupesh K. Mohan, A. M. Vinu Wang, Joseph
Description	Country affiliation: United States Author Affiliation: Mohan AM ( Department of NanoEngineering, University of California, San Diego, La Jolla, CA 92093, USA.); Windmiller JR ( Biolinq inc., 6191 Cornerstone Court East, Suite 109, San Diego, CA 92121, USA.); Mishra RK ( Department of NanoEngineering, University of California, San Diego, La Jolla, CA 92093, USA.); Wang J ( Department of NanoEngineering, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: josephwang@eng.ucsd.edu.)
Abstract	The present work describes an attractive skin-worn microneedle sensing device for the minimally invasive electrochemical monitoring of subcutaneous alcohol. The device consists of an assembly of pyramidal microneedle structures integrated with Pt and Ag wires, each with a microcavity opening. The microneedle aperture was modified by electropolymerizing o-phenylene diamine onto the Pt wire microtransducer, followed by the immobilization of alcohol oxidase (AOx) in an intermediate chitosan layer, along with an outer Nafion layer. The resulting microneedle-based enzyme electrode displays an interference-free ethanol detection in artificial interstitial fluid without compromising its sensitivity, stability and response time. The skin penetration ability and the efficaciousness of the biosensor performance towards subcutaneous alcohol monitoring was substantiated by the ex vivo mice skin model analysis. Our results reveal that the new microneedle sensor holds considerable promise for continuous non-invasive alcohol monitoring in real-life situations.
ISSN	09565663
Volume Number	91
e-ISSN	18734235
Journal	Biosensors and Bioelectronics
Language	English
Publisher	Elsevier
Publisher Date	2017-05-15
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biosensing Techniques Instrumentation Ethanol Analysis Extracellular Fluid Chemistry Needles Skin Alcohol Oxidoreductases Animals Chitosan Enzymes, Immobilized Equipment Design Fluorocarbon Polymers Mice Platinum Silver Journal Article Discipline Biotechnology
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry

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