NDLI: Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers.

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Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Whitty, Christopher J. Manning-bog, Amy B. Pruetz, Barb Mash, Deborah C. Sacchetti, Paola Michelhaugh, Sharon K. Schmidt, Carl J. Bannon, Michael J. Granneman, James G.
Description	Author Affiliation: Bannon MJ ( Department of Psychiatry and Behavioral Neurosciences, Pharmacology, and Pathology, Wayne State University School of Medicine, 2309 Scott Hall, 540 East Canfield Avenue, Detroit, MI 48201, USA. mbannon@med.wayne.edu);
Abstract	Chronic exposure to cocaine induces long-term adaptations that are likely to involve changes in transcription factor expression. This possibility has not been examined in the cocaine-exposed human brain. The transcription factor nurr1 is highly expressed in rodent midbrain dopamine neurons and is essential for their proper phenotypic development. Here we show that human NURR1 gene expression is robust within control subjects and reduced markedly within the dopamine neurons of human cocaine abusers. NURR1 is known to regulate transcription of the gene encoding the cocaine-sensitive dopamine transporter (DAT). We show here that DAT gene expression also is reduced markedly in the dopamine neurons of NURR1-deficient cocaine abusers, suggesting that NURR1 plays a critical role in vivo in controlling human DAT gene expression and adaptation to repeated exposure to cocaine.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cocaine Adverse Effects DNA-Binding Proteins Dopamine Metabolism Membrane Glycoproteins Nerve Tissue Proteins Neurons Transcription Factors Biosynthesis Autopsy Brain Case-Control Studies Dopamine Plasma Membrane Transport Proteins Immunohistochemistry In Situ Hybridization Membrane Transport Proteins Nuclear Receptor Subfamily 4, Group A, Member 2 Opioid-Related Disorders Phenotype RNA, Messenger Substance-Related Disorders Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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