NDLI: Regulation of transcription by H1 phosphorylation in Tetrahymena is position independent and requires clustered sites.

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Regulation of transcription by H1 phosphorylation in Tetrahymena is position independent and requires clustered sites.

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Regulation of transcription by H1 phosphorylation in Tetrahymena is position independent and requires clustered sites.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dou, Yali Gorovsky, Martin A.
Description	Author Affiliation: Dou Y ( Department of Biology, University of Rochester, Rochester, NY 14627, USA.);
Abstract	In Tetrahymena cells, constitutive phosphorylation of histone H1 phenocopies the loss of H1 from chromatin. Regulation of transcription by H1 phosphorylation is achieved by altering the overall charges of a small domain. Here, we further explore the electrostatic properties of this domain and the mechanism by which it regulates transcription. We demonstrate that the regulatory effect of the clustered charges does not require any long-range interaction and is position independent. However, when the same number of charges was dispersed throughout the H1 molecule, the effect became undetectable. The results are explained by a nucleation-propagation model and provide in vivo evidence that the synergy of the clustered positive charges plays a role in histone function and gene regulation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Histones Chemistry Genetics Transcription, Genetic Animals Binding Sites Blotting, Northern Cell Line Cell Nucleus Metabolism Electrophysiology Gene Expression Regulation Mutation Phosphorylation Protein Structure, Tertiary Tetrahymena Time Factors Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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