NDLI: Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2002 Volume: 99 Issue: 26

Year: 2002 Volume: 99 Issue: 25

Year: 2002 Volume: 99 Issue: 24

Year: 2002 Volume: 99 Issue: 23

Year: 2002 Volume: 99 Issue: 22

Year: 2002 Volume: 99 Issue: 21

Year: 2002 Volume: 99 Issue: 20

Year: 2002 Volume: 99 Issue: 19

Year: 2002 Volume: 99 Issue: 18

Year: 2002 Volume: 99 Issue: 17

Year: 2002 Volume: 99 Issue: 16

Year: 2002 Volume: 99 Issue: 15

Year: 2002 Volume: 99 Issue: 14

Year: 2002 Volume: 99 Issue: 13

Year: 2002 Volume: 99 Issue: 12

Year: 2002 Volume: 99 Issue: 11

Year: 2002 Volume: 99 Issue: 10

Year: 2002 Volume: 99 Issue: 9

Genetic analysis of traditional and evolved Basmati and non-Basmati rice varieties by using fluorescence-based ISSR-PCR and SSR markers.

A mutation that prevents paramutation in maize also reverses Mutator transposon methylation and silencing.

Pregnancy status and fetal prion genetics determine PrPSc accumulation in placentomes of scrapie-infected sheep.

Distinct roles for jasmonate synthesis and action in the systemic wound response of tomato.

Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors.

Glycine residues in potassium channel-like selectivity filters determine potassium selectivity in four-loop-per-subunit HKT transporters from plants

Plasticity of orientation preference maps in the visual cortex of adult cats.

Adaptive aberration correction in a confocal microscope.

Molecular characterization of meiotic recombination across the 140-kb multigenic a1-sh2 interval of maize.

Allometric scaling and maximum efficiency in physiological eigen time.

Sustained stimulation shifts the mechanism of endocytosis from dynamin-1-dependent rapid endocytosis to clathrin- and dynamin-2-mediated slow endocytosis in chromaffin cells

Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders.

Truncated hemoglobin HbN protects Mycobacterium bovis from nitric oxide.

Isoform-specific interaction of HP1 with human $TAF_{II}130$

Retroviral-mediated transmission of a mouse VL30 RNA to human melanoma cells promotes metastasis in an immunodeficient mouse model.

Antigen challenge leads to in vivo activation and elimination of highly polarized TH1 memory T cells.

Lysosomal destabilization in p53-induced apoptosis.

Ab initio protein structure prediction on a genomic scale: application to the Mycoplasma genitalium genome.

Tau is essential to beta -amyloid-induced neurotoxicity.

Genetic complementation in apicomplexan parasites.

Kinesin-microtubule binding depends on both nucleotide state and loading direction.

Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers.

Evolution of supercolonies: the Argentine ants of southern Europe.

Curvature of co-links uncovers hidden thematic layers in the World Wide Web.

Climate change hastens population extinctions.

Utility and distribution of conserved noncoding sequences in the grasses.

General and variable features of varicosity spacing along unmyelinated axons in the hippocampus and cerebellum.

Requirement of $Ca^{2+}$ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-γ

Holding two heads together: stability of the myosin II rod measured by resonance energy transfer between the heads.

Hemagglutinin sequence clusters and the antigenic evolution of influenza A virus.

A dynamic shift of VEGF isoforms with a transient and selective progesterone-induced expression of VEGF189 regulates angiogenesis and vascular permeability in human uterus.

Antioxidant-induced changes in oxidized DNA.

Evidence for interpersonal violence in the St. Cesaire Neanderthal.

From intestine to muscle: nuclear reprogramming through defective cloned embryos.

Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death.

Chiral protein scissors: high enantiomeric selectivity for binding and its effect on protein photocleavage efficiency and specificity.

Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a.

Cys-328 of IscS and Cys-63 of IscU are the sites of disulfide bridge formation in a covalently bound IscS/IscU complex: implications for the mechanism of iron-sulfur cluster assembly.

Altered sexual and social behaviors in trp2 mutant mice.

Animal antibiotic use has an early but important impact on the emergence of antibiotic resistance in human commensal bacteria.

Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions.

Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22.

Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle.

Evolution of the RNA polymerase II C-terminal domain.

Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography.

Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids in the alkaloid-defended arctiid moth Tyria jacobaeae.

Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa.

A family of RRM-type RNA-binding proteins specific to plant mitochondria.

Functional consequences of caspase activation in cardiac myocytes.

Regulation of transcription by H1 phosphorylation in Tetrahymena is position independent and requires clustered sites.

Interactions that determine the assembly of a retinoid X receptor/corepressor complex.

Conformational pathways in the gating of Escherichia coli mechanosensitive channel.

Genetic dissection of polyunsaturated fatty acid synthesis in Caenorhabditis elegans.

Genetic basis for queen-worker dimorphism in a social insect.

cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions.

Kinetics and mechanism of the DNA double helix invasion by pseudocomplementary peptide nucleic acids.

YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site.

Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9

IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA.

Mechanisms of noise-resistance in genetic oscillators.

Oligo(dT) primer generates a high frequency of truncated cDNAs through internal poly(A) priming during reverse transcription.

MIP-1alpha, MIP-1beta, RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines.

Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein

Organic semiconductors: a theoretical characterization of the basic parameters governing charge transport.

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells.

Interrogating protein interaction networks through structural biology.

Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues.

Interactions between thalamic and cortical rhythms during semantic memory recall in human.

Reconciling paleodistribution models and comparative phylogeography in the Wet Tropics rainforest land snail Gnarosophia bellendenkerensis (Brazier 1875).

Precision and functional specificity in mRNA decay.

The crystal structure of exonuclease RecJ bound to $Mn^{2+}$ ion suggests how its characteristic motifs are involved in exonuclease activity

An alternative carotenoid-to-bacteriochlorophyll energy transfer pathway in photosynthetic light harvesting.

Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.

IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells.

Antibiotics in agriculture: when is it time to close the barn door?

Unraveling the genetics and mechanisms of cardiac arrhythmia.

Disentangling the MYC web.

Brain-directed gene therapy for lysosomal storage disease: going well beyond the blood- brain barrier.

Finding the crosswalks on DNA.

The concerted mechanism of photo-induced biprotonic transfer in 7-azaindole dimers: structure, quantum-theoretical analysis, and simultaneity principles.

The concerted mechanism of photo-induced biprotonic transfer in 7-azaindole dimers: a model for the secondary evolution of the classic C2h dimer and comparison of four mechanisms.

Determination of causal connectivities of species in reaction networks.

Loss of the membrane anchor of the target receptor is a mechanism of bioinsecticide resistance.

The crystal structure of rabbit phosphoglucose isomerase complexed with 5-phospho-d-arabinonohydroxamic acid

Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits.

Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei.

The identification of functional modules from the genomic association of genes.

Catalysis of S-nitrosothiols formation by serum albumin: The mechanism and implication in vascular control

A chloroplast-resident DNA methyltransferase is responsible for hypermethylation of chloroplast genes in Chlamydomonas maternal gametes.

Calreticulin recognizes misfolded HLA-A2 heavy chains.

Direct mass spectrometric analysis of intact proteins of the yeast large ribosomal subunit using capillary LC/FTICR.

Modulation of tRNAAla identity by inorganic pyrophosphatase.

Observation by fluorescence microscopy of transcription on single combed DNA.

Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells.

Estimates of lateral and longitudinal bond energies within the microtubule lattice.

The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins.

The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation.

A single domestication for maize shown by multilocus microsatellite genotyping.

The global phylogeny of glycolytic enzymes.

Mutator clones of Neisseria meningitidis in epidemic serogroup A disease.

Intron evolution as a population-genetic process.

Dental microstructure and life history in subfossil Malagasy lemurs.

Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies.

Reverse engineering gene networks using singular value decomposition and robust regression

Asymmetrical flagellar rotation in Borrelia burgdorferi nonchemotactic mutants.

Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs.

ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells.

Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells.

Inactivation of the murine X-linked juvenile retinoschisis gene, Rs1h, suggests a role of retinoschisin in retinal cell layer organization and synaptic structure.

Neutrophils are indispensable for hematopoietic stem cell mobilization induced by interleukin-8 in mice.

Differential regulation of the human and murine CD34 genes in hematopoietic stem cells

bcl-2 overexpression promotes myocyte proliferation.

Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes.

Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size.

Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans.

Heparan sulfate proteoglycan-dependent induction of axon branching and axon misrouting by the Kallmann syndrome gene kal-1.

Neurotrophin secretion from hippocampal neurons evoked by long-term-potentiation-inducing electrical stimulation patterns

Visualization of $Ca^{2+}$ entry through single stretch-activated cation channels

Ectopic D-type cyclin expression induces not only DNA replication but also cell division in Arabidopsis trichomes.

Expression and disruption of the Arabidopsis TOR (target of rapamycin) gene.

Year: 2002 Volume: 99 Issue: 8

Year: 2002 Volume: 99 Issue: 7

Year: 2002 Volume: 99 Issue: 6

Year: 2002 Volume: 99 Issue: 5

Year: 2002 Volume: 99 Issue: 4

Year: 2002 Volume: 99 Issue: Suppl 4

Year: 2002 Volume: 99 Issue: 3

Year: 2002 Volume: 99 Issue: Suppl 3

Year: 2002 Volume: 99 Issue: 2

Year: 2002 Volume: 99 Issue: Suppl 2

Year: 2002 Volume: 99 Issue: 1

Year: 2002 Volume: 99 Issue: Suppl 1

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Papadatos, G. Alex Wallerstein, Polly M. R. Vandenberg, Jamie I. Saumarez, Richard C. Grace, Andrew A. Brady, Peter A. Head, Catherine E. G. Ratcliff, Rosemary Trezise, Ann E. O. Huang, Christopher L-h Benndorf, Klaus Colledge, William H.
Description	Author Affiliation: Papadatos GA ( Section of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, United Kingdom.);
Abstract	Voltage-gated sodium channels drive the initial depolarization phase of the cardiac action potential and therefore critically determine conduction of excitation through the heart. In patients, deletions or loss-of-function mutations of the cardiac sodium channel gene, SCN5A, have been associated with a wide range of arrhythmias including bradycardia (heart rate slowing), atrioventricular conduction delay, and ventricular fibrillation. The pathophysiological basis of these clinical conditions is unresolved. Here we show that disruption of the mouse cardiac sodium channel gene, Scn5a, causes intrauterine lethality in homozygotes with severe defects in ventricular morphogenesis whereas heterozygotes show normal survival. Whole-cell patch clamp analyses of isolated ventricular myocytes from adult Scn5a(+/-) mice demonstrate a approximately 50% reduction in sodium conductance. Scn5a(+/-) hearts have several defects including impaired atrioventricular conduction, delayed intramyocardial conduction, increased ventricular refractoriness, and ventricular tachycardia with characteristics of reentrant excitation. These findings reconcile reduced activity of the cardiac sodium channel leading to slowed conduction with several apparently diverse clinical phenotypes, providing a model for the detailed analysis of the pathophysiology of arrhythmias.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Sodium Channels Genetics Physiology Tachycardia, Ventricular Animals Cell Survival Electrocardiography Electrophysiology Exons Heterozygote Homozygote Mice Models, Genetic Mutation NAV1.5 Voltage-Gated Sodium Channel Patch-Clamp Techniques Perfusion Phenotype Metabolism Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in