NDLI: Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice.

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Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice.

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Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Caron, M. G. Giros, B. Jaber, M. Dumartin, B. Gonon, F. Bloch, B.
Description	Author Affiliation: Dumartin B ( Laboratoire d'Histologie-Embryologie, Unite Mixte de Recherche Centre National de la Recherche Scientifique 5541, Interactions Neuronales et Comportements, Université V. Ségalen, 146 Rue Léo-Saignat, 33076 Bordeaux Cedex, France.);
Abstract	In vivo, G protein-coupled receptors (GPCR) for neurotransmitters undergo complex intracellular trafficking that contribute to regulate their abundance at the cell surface. Here, we report a previously undescribed alteration in the subcellular localization of D1 dopamine receptor (D1R) that occurs in vivo in striatal dopaminoceptive neurons in response to chronic and constitutive hyperdopaminergia. Indeed, in mice lacking the dopamine transporter, D1R is in abnormally low abundance at the plasma membrane of cell bodies and dendrites and is largely accumulated in rough endoplasmic reticulum and Golgi apparatus. Decrease of striatal extracellular dopamine concentration with 6-hydroxydopamine (6- OHDA) in heterozygous mice restores delivery of the receptor from the cytoplasm to the plasma membrane in cell bodies. These results demonstrate that, in vivo, in the central nervous system, the storage in cytoplasmic compartments involved in synthesis and the membrane delivery contribute to regulate GPCR availability and abundance at the surface of the neurons under control of the neurotransmitter tone. Such regulation may contribute to modulate receptivity of neurons to their endogenous ligands and related exogenous drugs.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Carrier Proteins Genetics GTP-Binding Proteins Metabolism Membrane Glycoproteins Membrane Transport Proteins Nerve Tissue Proteins Receptors, Dopamine D1 Animals Dopamine Dopamine Plasma Membrane Transport Proteins Electrochemistry Endoplasmic Reticulum Golgi Apparatus Immunohistochemistry Mice Mice, Knockout Microscopy, Electron Oxidopamine Pharmacology Prosencephalon Drug Effects Ultrastructure Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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