NDLI: Hemagglutinin sequence clusters and the antigenic evolution of influenza A virus.

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Hemagglutinin sequence clusters and the antigenic evolution of influenza A virus.

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Hemagglutinin sequence clusters and the antigenic evolution of influenza A virus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Plotkin, Joshua B. Dushoff, Jonathan Levin, Simon A.
Description	Author Affiliation: Plotkin JB ( Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08540, USA. plotkin@ias.edu);
Abstract	Continual mutations to the hemagglutinin (HA) gene of influenza A virus generate novel antigenic strains that cause annual epidemics. Using a database of 560 viral RNA sequences, we study the structure and tempo of HA evolution over the past two decades. We detect a critical length scale, in amino acid space, at which HA sequences aggregate into clusters, or swarms. We investigate the spatio-temporal distribution of viral swarms and compare it to the time series of the influenza vaccines recommended by the World Health Organization. We introduce a method for predicting future dominant HA amino acid sequences and discuss its potential relevance to vaccine choice. We also investigate the relationship between cluster structure and the primary antibody-combining regions of the HA protein.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Hemagglutinins Genetics Influenza A Virus Mutation Vaccines Antibodies Metabolism Binding Sites Databases As Topic Genotype Influenza Vaccines Models, Genetic Multigene Family Time Factors Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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