NDLI: Antigen challenge leads to in vivo activation and elimination of highly polarized TH1 memory T cells.

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Antigen challenge leads to in vivo activation and elimination of highly polarized TH1 memory T cells.

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Antigen challenge leads to in vivo activation and elimination of highly polarized TH1 memory T cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hayashi, Nobuki Liu, Dacai Ben-sasson, Shlomo Z. Paul, William E. Min, Booki
Description	Author Affiliation: Hayashi N ( Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.);
Abstract	TH1 memory T cells derived from T cell receptor transgenic mice, in which the T cell antigen receptor is specific for a cytochrome C peptide in association with I-E(k), were transferred into normal B10.A mice and allowed to adopt a resting phenotype. When challenged, 30-60 days after transfer, with i.v. cytochrome C, the transgenic cells rapidly became activated, expressed mRNA for IFNgamma, and began to divide. However, after 48 h, the frequency of the cells fell progressively, reaching levels only slightly above the limit of detection by day 8 and thereafter remain depressed for up to 90 days. The remaining cells were anergic as shown by limitation in proliferation and IFNgamma production in response to in vitro antigen stimulation. Even if challenged with antigen emulsified in complete Freund's adjuvant, the overall pattern was similar, except that in the draining lymph nodes, the surviving antigen-specific cells were not anergic, although spleen cells were still strikingly anergic. Thus, antigenic challenge of mice possessing resting memory TH1 CD4 T cells leads to the unanticipated loss of most of the specific cells and an apparent depletion rather than enhancement of immunologic memory.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigen Presentation Immunologic Memory Th1 Cells Immunology Animals Apoptosis CD4-Positive T-Lymphocytes Metabolism Cells, Cultured Cytochrome c Group Pharmacology Interferon-gamma Mice Mice, Transgenic Phenotype Reverse Transcriptase Polymerase Chain Reaction Time Factors Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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