NDLI: Animal antibiotic use has an early but important impact on the emergence of antibiotic resistance in human commensal bacteria.

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Animal antibiotic use has an early but important impact on the emergence of antibiotic resistance in human commensal bacteria.

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Animal antibiotic use has an early but important impact on the emergence of antibiotic resistance in human commensal bacteria.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Silbergeld, Ellen K. Johnson, Judith A. Morris, J. Glenn Harris, Anthony D. Smith, David L.
Description	Author Affiliation: Smith DL ( Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. dave@needles.umaryland.edu);
Abstract	Antibiotic use is known to promote the development of antibiotic resistance, but substantial controversy exists about the impact of agricultural antibiotic use (AAU) on the subsequent emergence of antibiotic-resistant bacteria among humans. AAU for animal growth promotion or for treatment or control of animal diseases generates reservoirs of antibiotic-resistant (AR) bacteria that contaminate animal food products. Mathematical models are an important tool for understanding the potential medical consequences of this increased exposure. We have developed a mathematical model to evaluate factors affecting the prevalence of human commensal AR bacteria that cause opportunistic infections (e.g., enterococci). Our analysis suggests that AAU hastens the appearance of AR bacteria in humans. Our model indicates that the greatest impact occurs very early in the emergence of resistance, when AR bacteria are rare, possibly below the detection limits of current surveillance methods.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Agriculture Animal Diseases Drug Therapy Anti-Bacterial Agents Pharmacology Algorithms Microbiology Animals Animals, Domestic Bacteria Metabolism Bacterial Infections Drug Resistance, Microbial Drug Resistance, Multiple Models, Theoretical Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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