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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zeng, Xiankun Chauhan, Chhavi Hou, Steven X. |
| Description | Country affiliation: United States Author Affiliation: Zeng X ( Mouse Cancer Genetics Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland, USA. zengx2@mail.nih.gov) |
| Abstract | The homeostasis of Drosophila midgut is maintained by multipotent intestinal stem cells (ISCs), each of which gives rise to a new ISC and an immature daughter cell, enteroblast (EB), after one asymmetric cell division. In Drosophila, the Gal4-UAS system is widely used to manipulate gene expression in a tissue- or cell-specific manner, but in Drosophila midgut, there are no ISC- or EB-specific Gal4 lines available. Here we report the generation and characterization of Dl-Gal4 and Su(H)GBE-Gal4 lines, which are expressed specifically in the ISCs and EBs separately. Additionally, we demonstrate that Dl-Gal4 and Su(H)GBE-Gal4 are expressed in adult midgut progenitors (AMPs) and niche peripheral cells (PCs) separately in larval midgut. These two Gal4 lines will serve as invaluable tools for navigating ISC behaviors. |
| File Format | HTM / HTML |
| ISSN | 1526954X |
| e-ISSN | 1526968X |
| DOI | 10.1002/dvg.20661 |
| Journal | genesis |
| Issue Number | 10 |
| Volume Number | 48 |
| Language | English |
| Publisher | Wiley-Liss |
| Publisher Date | 2010-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Genetics Discipline Developmental Biology Discipline Embryology Drosophila Proteins Metabolism Drosophila Melanogaster Intestines Cytology Stem Cells Animals Animals, Genetically Modified Dna-binding Proteins Fluorescent Antibody Technique, Indirect Larva Saccharomyces Cerevisiae Proteins Transcription Factors Transgenes Research Support, N.i.h., Intramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Genetics Medicine Endocrinology |
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