NDLI: Nephroprotection of plantamajoside in rats treated with cadmium.

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Nephroprotection of plantamajoside in rats treated with cadmium.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jung, Ha-Young Seo, Dong-Won Hong, Chung-Oui Kim, Ji-Yeon Yang, Sung-Yong Lee, Kwang-Won
Description	Author Affiliation: Jung HY ( Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University, Seoul 136-713, Republic of Korea.); Seo DW ( Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University, Seoul 136-713, Republic of Korea); Hong CO ( Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University, Seoul 136-713, Republic of Korea.); Kim JY ( Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University, Seoul 136-713, Republic of Korea.); Yang SY ( Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University, Seoul 136-713, Republic of Korea.); Lee KW ( Department of Food Bioscience and Technology, College of Life Science & Biotechnology, Korea University, Seoul 136-713, Republic of Korea. Electronic address: kwangwon@korea.ac.kr.)
Abstract	Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Plantamajoside (PMS), a major compound of Plantago asiatica (PA), was reported to have the antioxidant effects. In this study, we investigated the protective effects of PMS on Cd-induced renal damage in the NRK-52E cell and rat kidney tissue. Cd exposure increased the ROS generation, lipid peroxidation, serum biochemical values of renal damage, and mRNA and protein expressions of KIM-1 in vitro and in vivo. The significant reduction in glutathione (GSH)/glutathione disulfide (GSSG) ratio and activities of antioxidant enzymes were also observed in the rats treated with Cd. PMS significantly decreased the ROS generation and lipid peroxidation, thus enhancing GSH/GSSG ratio, antioxidant enzyme activities in the cells and rats, and improved histochemical appearances, indicating that PMS has protective activities against Cd-induced renal injury.
File Format	HTM / HTML
ISSN	13826689
Issue Number	1
Volume Number	39
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2015-01-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Cadmium Toxicity Catechols Therapeutic Use Environmental Pollutants Glucosides Kidney Diseases Drug Therapy Protective Agents Animals Pharmacokinetics Catalase Metabolism Pharmacology Cell Adhesion Molecules Genetics Cell Line Cell Survival Drug Effects Glutathione Glutathione Disulfide Glutathione Peroxidase Kidney Pathology Chemically Induced Lipid Peroxidation Male Rats, Sprague-dawley Reactive Oxygen Species Superoxide Dismutase Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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