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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ciftci, Osman Disli, Olcay Murat Timurkaan, Necati |
| Description | Country affiliation: Turkey Author Affiliation: Ciftci O ( 1Department of Pharmaceutical Toxicology, University of Inonu, Malatya, Turkey.) |
| Abstract | 2,3,7,8-Tetracholorodibenzo-p-dioxin (TCDD) is a highly toxic environmental contaminant that causes severe toxic effects in animal and human. In this study, we investigated the toxic effects of TCDD and the preventive effects of protocatechuic acid (PCA), a widespread phenolic compound, in the heart tissue of rats. For this purpose, 3-4 months old 28 rats with 280-310 g body weights were equally divided into 4 groups (control, TCDD, PCA, TCDD + PCA group). A 2 µg/kg dose of 2,3,7,8-TCDD and 100 mg/kg dose of PCA were dissolved in corn oil and given orally to the rats for 45 days. The results indicated that TCDD induced oxidative stress by increasing the level of thiobarbituric acid reactive substance and by decreasing the levels of glutathione, catalase, glutathione peroxidase and superoxide dismutase in the heart tissue of rats. In contrast, PCA treatment prevents the toxic effects of TCDD on oxidative stress. In addition, histopathological alterations such as necrosis and hemorrhage occurred in TCDD group, and PCA treatment partially prevents these alterations in heart tissue. In this study, it was concluded that TCDD exposure led to toxic effects in heart tissue and PCA treatment could prevent the toxicity of TCDD. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 9 |
| Volume Number | 29 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2013-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Anticarcinogenic Agents Pharmacology Heart Drug Effects Hydroxybenzoates Oxidative Stress Toxicity Animals Carcinogens Catalase Metabolism Dose-response Relationship, Drug Glutathione Glutathione Peroxidase Physiopathology Male Rats Rats, Sprague-dawley Superoxide Dismutase Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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